When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                
                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 

                                                 A   T   A   A   P   P   S   L   F   P   L   I   H   P   R   C 
  X82109   IGHA3*01 F  (CH1)    ... ... ... .ga gcg acc gcg gcc cct ccc agc ctc ttc ccg ctg atc cac ccc aga tgt


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 

                                 A   L   K   D   T       P   A   T   V   I   A   G   C   L   I   R   G   F   F 
  X82109   IGHA3*01 F  (CH1)    gca tta aaa gac act ... cca gcg acc gtg atc gcc ggc tgc ctg atc cgg ggc ttc ttc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6

                                 P   L       G   P   L   S   V   S   W   N   A   S   G                         
  X82109   IGHA3*01 F  (CH1)    ccc ctg ... ggc cct ctg agt gtg agc tgg aac gcc agc ggg ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4

                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     K   N   V   T   F   P   P   V   P   S   G   T   S                       G 
  X82109   IGHA3*01 F  (CH1)    ... aag aac gtg acc ttc cca ccc gtc ccg tct ggc act tca ... ... ... ... ... ggc


                                ____________                                                ___EF___            

                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 

                                 P   Y   T   T   C   S   L   L   S   L   T   P   E   Q   C           P   E   D 
  X82109   IGHA3*01 F  (CH1)    ccg tac acc acg tgc agc ctg ctg agc cta aca ccg gag cag tgt ... ... cct gag gat


                                                    _________________________FG_________________________        
                                
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 

                                 H   N   V   V   C   H   V   E   H   N               Y   D   E   G   Q   N   L 
  X82109   IGHA3*01 F  (CH1)    cac aat gtg gtc tgc cac gtg gag cac aac ... ... ... tat gac gag ggc cag aat ctg


                                                    
                                
                                120 121 122 123 124 

                                 T   V   L   Y   P  
  X82109   IGHA3*01 F  (CH1)    act gtg ctc tac cca 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18 
                                 E   C   K   D   P   N   S   D   P   T   P   C   P   C   P   P   I   T  
  X82109   IGHA3*01 F  (H)      gag tgc aaa gat cca aat tca gat cca acc ccc tgc ccc tgc ccc ccc atc acc 

                                                                                                                
                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 

                                                         C   G   E   P   S   L   S   L   Q   R   P   D   I   G 
  X82109   IGHA3*01 F  (CH2)    ... ... ... ... ... ... tgc ggg gag cca agc ctg tcc ctg cag cgg cca gac atc ggg


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 

                                 D   L   L   L           E   S   N   A   S   L   T   C   T   L   S   G   L   K 
  X82109   IGHA3*01 F  (CH2)    gac ctg ctc ctg ... ... gaa tcg aac gcc agc ctc acc tgc acc ctg agc ggc ctg aag


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6

                                 D   P       E   G   A   V   F   T   W   N   P   T   N   G   N   E             
  X82109   IGHA3*01 F  (CH2)    gac ccc ... gag ggt gcc gtc ttc acc tgg aat ccc aca aat ggg aac gaa ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4

                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   S   T   Q   S   Y   P   C   G                             
  X82109   IGHA3*01 F  (CH2)    ... ccc gtg cag cag agc acc cag agt tac ccg tgc ggc ... ... ... ... ... ... ...


                                ____________                                                ___EF___            

                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 

                                 C   Y   S   V   S   S   V   L   P   G   C   A   E   P   W           N   A   G 
  X82109   IGHA3*01 F  (CH2)    tgc tac agt gtg tcc agc gtg ctg ccc ggc tgt gcg gag ccc tgg ... ... aat gcg ggg


                                                    _________________________FG_________________________        
                                
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 

                                 T   E   F   T   C   T   V   T   H   P   E       I   E   G   G   S   L   T   A 
  X82109   IGHA3*01 F  (CH2)    aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gag ggc ggc tcc ctg aca gcc


                                                
                                
                                120 121 122 123 
                                 T   I   S   R  
  X82109   IGHA3*01 F  (CH2)    acc atc agc aga 


                                                                                                                
                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 

                                                 G   S   L   T   P   P   Q   V   H   L   L   P   P   P   T   E 
  X82109   IGHA3*01 F  (CH3)    ... ... ... ... ggc agc ctc acc ccg ccc cag gtc cac ctg ctg ccg ccg ccg act gag


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 

                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X82109   IGHA3*01 F  (CH3)    gaa ctg gcc ctc ... ... aac gcg ctg gtg acg ctg acc tgc ctg gtg agg ggc ttc agc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6

                                 P           K   D   V   L   V   S   W   T   H   N   G   T   L   V   V   P   K 
  X82109   IGHA3*01 F  (CH3)    ccc ... ... aag gac gtg ctg gtg tcc tgg aca cac aac ggc acc ctg gtg gtc ccc aaa


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4

                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 D   S   F   L   V   W   K   P   L   P   E   P   G   Q   E               P   T 
  X82109   IGHA3*01 F  (CH3)    gac agc ttc ctg gtg tgg aag ccc ctg cct gag ccc ggc cag gaa ... ... ... ccc acc


                                ____________                                                ___EF___            

                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 

                                 T   Y   A   V   T   S   L   L   R   V   P   A   E   D   W           N   Q   G 
  X82109   IGHA3*01 F  (CH3)    acc tac gct gtc acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag ggg


                                                    _________________________FG_________________________        
                                
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 

                                 D   S   Y   S   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82109   IGHA3*01 F  (CH3)    gac agc tac tcc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cat ttc acc cag aag


                                                                    ______________________________________CHS__
                                
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 

                                 T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  X82109   IGHA3*01 F  (CH3)    acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc


                                ____________________________________
                                
                                140 141 142 143 144 145 146 147 148 

                                 V   A   D   V   E   A   V   C   Y  
  X82109   IGHA3*01 F  (CH3)    gtg gca gac gtg gaa gcc gtg tgc tac