When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 V   P   A   T   P   P   I   I   F   P   L   T   C   P   G   C 
  X82110   IGHA4*01 F  (CH1)    ... ... ... ... gtg cct gca acc ccc ccg atc atc ttc ccg ctg acc tgc ccc ggg tgt
                                                                                                               
  AY386696 IGHA4*02 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 V   L   K   D   T       S   A   T   I   V   A   G   C   L   I   R   G   F   F 
  X82110   IGHA4*01 F  (CH1)    gta ctg aaa gac act ... tca gcg acc att gtc gcg ggc tgc ctg atc cgg ggc ttc ttc
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- ... --- --- --- --- --- --c --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P   R       G   P   L   G   V   T   W   N   D   N   R                         
  X82110   IGHA4*01 F  (CH1)    ccc cgg ... ggc cct cta ggt gtg aca tgg aac gac aac agg ... ... ... ... ... ...
                                                         S                                                     
  AY386696 IGHA4*02 F           --- --- ... --- --- --g a-- --- --- --- --- --- --- --- ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     A   N   L   T   F   P   P   V   Q   S   A   T   S                       S 
  X82110   IGHA4*01 F  (CH1)    ... gca aac ctg acc ttc cca cct gtc cag tct gcc acc tcg ... ... ... ... ... agc
                                                                                                               
  AY386696 IGHA4*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   Y   T   T   C   S   V   L   S   L   P   A   E   Q   C           P   A   G 
  X82110   IGHA4*01 F  (CH1)    ctg tac acc acg tgc agc gtg ctg agc ctg cca gct gag cag tgt ... ... cct gca gga
                                                         L                                                     
  AY386696 IGHA4*02 F           --- --- --- --- --- --- c-- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 N   S   V   A   C   R   V   E   H   N                   N   K   R   Q   D   L 
  X82110   IGHA4*01 F  (CH1)    aac agt gtg gcc tgc cgc gtg gag cac aac ... ... ... ... aac aag cgc cag gac ctg
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                                    
                                120 121 122 123 124 
                                 T   V   P   C   L  
  X82110   IGHA4*01 F  (CH1)    act gtg ccc tgc cta 
                                                    
  AY386696 IGHA4*02 F           --- --- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 A   C   N   K   P   T   I   E   P   P   T   K   P   T   C   P   C   P   C   P 
  X82110   IGHA4*01 F  (H)      gct tgc aat aag ccc acc ata gaa cca cca acg aaa ccc acc tgc ccc tgc ccc tgc ccc
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                
                                
                                 21  22  23 
                                 S   P   S  
  X82110   IGHA4*01 F  (H)      tcc ccc tcc 
                                            
  AY386696 IGHA4*02 F           --- --- --- 


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         C   G   K   P   S   L   S   L   Q   R   P   D   L   G 
  X82110   IGHA4*01 F  (CH2)    ... ... ... ... ... ... tgt ggg aag ccc agc ctg tcc ctg cag cgg cca gac ctc ggg
                                                                                                               
  AY386696 IGHA4*02 F           ... ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           D   S   N   A   S   L   T   C   T   L   R   G   L   L 
  X82110   IGHA4*01 F  (CH2)    gac ctg ctc ctg ... ... gac tcg aac gcc agc ctc acc tgc acc ctg aga ggc ctg ctg
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 N   P       E   G   A   V   F   T   W   N   P   T   N   G   K   E             
  X82110   IGHA4*01 F  (CH2)    aac ccc ... gag ggc gcc gtc ttc acc tgg aat ccc aca aat ggg aag gaa ... ... ...
                                                                                                               
  AY386696 IGHA4*02 F           --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   S   A   Q   R   D   H   C   G                             
  X82110   IGHA4*01 F  (CH2)    ... ccc gtc cag cag agc gcc cag cgt gac cac tgc ggc ... ... ... ... ... ... ...
                                                                                                               
  AY386696 IGHA4*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   G   C   A   E   P   W           N   A   G 
  X82110   IGHA4*01 F  (CH2)    tgc tac agt gtg tcc agc gtg ctg cct ggc tgt gcg gag ccc tgg ... ... aat gca ggg
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   V   F   T   C   T   V   T   H   P   E       I   D   S   G   S   L   T   A 
  X82110   IGHA4*01 F  (CH2)    aca gtc ttc acc tgc act gtc acc cac cct gag ... ata gac agc ggc tcc ctg aca gcc
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                                        
                                120 121 122 123 124 125 
                                 T   I   S   K   D   T  
  X82110   IGHA4*01 F  (CH2)    acc atc agc aaa gac aca 
                                                        
  AY386696 IGHA4*02 F           --- --- --- --- --- --- 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   S   L   I   P   P   Q   V   H   L   L   P   P   P   S   E 
  X82110   IGHA4*01 F  (CH3)    ... ... ... ... ggc agc ctc atc cca ccc cag gtc cac ctg ctg cca ccg cca tcg gag
                                                                                                               
  AY386696 IGHA4*02 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X82110   IGHA4*01 F  (CH3)    gag ctg gcc ctc ... ... aat gca ctg gtg aca ctg acc tgc ctg gtg cgg ggc ttc agc
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   Y   W   T   N   K   G   L   Q   V   P   K   D 
  X82110   IGHA4*01 F  (CH3)    ccc ... ... aag gac gtg ctg gtg tac tgg acg aac aaa ggc ctg cag gtc ccc aaa gac
                                                                                         V                     
  AY386696 IGHA4*02 F           --- ... ... --- --- --- --- --- --- --- --- --- --- --- g-- --- --- --- --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   F   L   V   W   K   P   L   P   E   P   G   Q   E               P   T 
  X82110   IGHA4*01 F  (CH3)    ... agc ttc ctg gtg tgg aag ccc ctg cct gag cca ggc cag gaa ... ... ... ccc acc
                                                                                                               
  AY386696 IGHA4*02 F           ... --- --- --- --- --- --- --- --- --- --- --c --- --- --- ... ... ... --- ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   A   V   T   S   L   L   R   V   P   A   E   D   W           N   Q   N 
  X82110   IGHA4*01 F  (CH3)    acc tac gcc gtc acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag aat
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   S   Y   T   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82110   IGHA4*01 F  (CH3)    gaa agc tac acc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                    ______________________________________CHS__                                
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  X82110   IGHA4*01 F  (CH3)    acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
                                                                                                               
  AY386696 IGHA4*02 F           --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                ____________________________________                                
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   G   V   C   Y  
  X82110   IGHA4*01 F  (CH3)    gtg gca gac gtg gaa ggc gtc tgc tac 
                                                                    
  AY386696 IGHA4*02 F           --- --- --- --- --- --- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 G   L   L   C   L   A   G   C   Q   E   P   L   P   C   V   V   L   D   L   P 
  AY386696 IGHA4*02 F  (M)      ggc ctt ctg tgt ctt gca ggt tgt cag gag ccc ctg ccc tgt gtg gtg ctg gat ctg cca


                                
                                
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                 Q   D   S   L   E   E   E   A   P   G   A   N   L   W   P   T   T   V   T   L 
  AY386696 IGHA4*02 F  (M)      cag gac agc ctg gag gag gag gcc ccc ggc gcc aac ctg tgg ccc acc acc gtc acc ctc


                                
                                
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 L   T   L   F   L   L   S   L   F   Y   S   T   A   L   T   M   T   N   I   R 
  AY386696 IGHA4*02 F  (M)      ctc act ctc ttc ctg ctg agc ctg ttc tac agc aca gct ctg acc atg aca aac atc cgg


                                
                                
                                 61  62  63  64  65  66  67  68  69  70  71 
                                 D   P   P   G   S   K   E   G   P   Q   Y  
  AY386696 IGHA4*02 F  (M)      gac cca cct ggc agc aaa gag gga ccc cag tac