When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 A   T   A   A   S   P   R   L   F   P   L   I   H   P   R   C 
  X82111   IGHA5*01 F  (CH1)    ... ... ... ... gcg act gcg gcc tct ccc agg ctc ttc cca ctg atc cac cct aga tgt
                                                 V   P       T   P       I   I               T   C       G     
  AF090367 IGHA5*02 F           ... ... ... ... -t- c-- --a a-- c-c --g -tc a-- --- --g --- -c- tg- --c g-g ---
                                                 V   P       T   P       I   I               T   C       G     
  AY386696 IGHA5*03 F           ... ... ... ... -t- c-- --a a-- c-c --g -tc a-- --- --g --- -c- tg- --c g-g ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 A   L   K   D   T       S   A   T   V   I   A   G   C   L   I   R   G   F   F 
  X82111   IGHA5*01 F  (CH1)    gca tta aaa gac act ... tca gcg acc gtg atc gcc ggc tgc ctg atc cgg ggc ttc ttc
                                 V                                       S                                     
  AF090367 IGHA5*02 F           -t- c-g --- --- --- ... --- --c --- --- tc- --- --- --- --- --- --- --- --- ---
                                 V                                   I   V                                     
  AY386696 IGHA5*03 F           -t- c-g --- --- --- ... --- --- --- a-t g-- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P   L       G   P   L   S   V   S   W   N   A   S   G                         
  X82111   IGHA5*01 F  (CH1)    ccc ctg ... ggc cct ctg agt gtg agc tgg aac gcc agc ggg ... ... ... ... ... ...
                                     R                                                                         
  AF090367 IGHA5*02 F           --- -g- ... --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
                                     R                                                                         
  AY386696 IGHA5*03 F           --- -g- ... --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     K   N   V   T   F   P   P   V   P   S   G   T   S                       G 
  X82111   IGHA5*01 F  (CH1)    ... aag aac gtg acc ttc cca ccc gtc ccg tct ggc act tca ... ... ... ... ... ggc
                                                                                                               
  AF090367 IGHA5*02 F           ... --- --- --- --t --- --g --- --- --- --- --- --- --- ... ... ... ... ... ---
                                                                                                               
  AY386696 IGHA5*03 F           ... --- --- --- --t --- --g --- --- --- --- --- --- --- ... ... ... ... ... ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 P   Y   T   T   C   S   L   L   S   L   T   P   E   Q   C           P   E   D 
  X82111   IGHA5*01 F  (CH1)    ccg tac acc acg tgc agc ctg ctg agc cta aca ccg gag cag tgt ... ... cct gag gat
                                                                                                               
  AF090367 IGHA5*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  AY386696 IGHA5*03 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 D   N   V   V   C   H   V   E   H   N               Y   D   K   G   Q   N   L 
  X82111   IGHA5*01 F  (CH1)    gac aat gtg gtc tgc cac gtg gag cac aac ... ... ... tat gac aag ggc cag aat ctg
                                                                                             E           D     
  AF090367 IGHA5*02 F           --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- g-- --- --- g-- t--
                                                                                             E           D     
  AY386696 IGHA5*03 F           --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- g-- --- --- g-- t--


                                                                                    
                                120 121 122 123 124 
                                 T   V   L   Y   P  
  X82111   IGHA5*01 F  (CH1)    act gtg ctc tac cca 
                                                    
  AF090367 IGHA5*02 F           --- --- --- --- --- 
                                                    
  AY386696 IGHA5*03 F           --- --- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 E   C   Q   P   P   T   P   S   P   T   T   P   T   T   C   P   C   P   C   P 
  X82111   IGHA5*01 F  (H)      gaa tgc caa ccg cca act cct agt cct aca act cca acc acc tgc ccc tgc ccc tgc ccc
                                                                                         A   T   T   S   G     
  AF090367 IGHA5*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --a gc- a-- aca t-- g-- ---
                                                                                         A   T   T   S   G     
  AY386696 IGHA5*03 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --a gc- a-- aca t-- g-- ---


                                
                                
                                 21  22  23 
                                 L   P   S  
  X82111   IGHA5*01 F  (H)      ctc ccc tcc 
                                 T          
  AF090367 IGHA5*02 F           ac- --- --- 
                                 T          
  AY386696 IGHA5*03 F           ac- --- --- 


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                         C   G   E   P   S   L   S   L   Q   R   P   D   L   G 
  X82111   IGHA5*01 F  (CH2)    ... ... ... ... ... ... tgt ggg gag ccc agc ctg tcc ctg cag cgg cca gac ctc ggg
                                                                                                               
  AF090367 IGHA5*02 F           ... ... ... ... ... ... --c --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHA5*03 F           ... ... ... ... ... ... --c --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           N   S   N   A   S   L   T   C   T   L   R   G   L   L 
  X82111   IGHA5*01 F  (CH2)    gac ctg ctc ctg ... ... aac tcg aac gcc agc ctc acc tgc acc ctg aga ggc ctg ttg
                                                                                            
  AF090367 IGHA5*02 F           --- --- --g --- ... ... --- --- --- --- --- --- --- --- --- -
                                                                                                               
  AY386696 IGHA5*03 F           --- --- --g --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 D   P       E   G   A   V   F   T   W   E   P   T   F   G   K   E             
  X82111   IGHA5*01 F  (CH2)    gac ccc ... gag ggc gcc gtc ttc acc tgg gag ccc aca ttt ggg aag gaa ... ... ...
  
  AF090367 IGHA5*02 F           
                                                                                     N       N                 
  AY386696 IGHA5*03 F           --- --- ... --- --- --- --- --- --- --- --- --- --- aac --- --c --- ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   L   S   P   R   L   D   H   C   G                             
  X82111   IGHA5*01 F  (CH2)    ... ccc gtc cag ctg agt ccc aga ctt gac cac tgc ggc ... ... ... ... ... ... ...
 
  AF090367 IGHA5*02 F           
                                                             K                                                 
  AY386696 IGHA5*03 F           ... --- --- --- --- --- --- -ag --- --- --- --- --- ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   G   C   A   A   A   W           N   A   G 
  X82111   IGHA5*01 F  (CH2)    tgc tac agt gtg tcc agc gtg ctg ccc ggc tgt gcg gcg gcc tgg ... ... aat gca ggg
  
  AF090367 IGHA5*02 F           
                                                                                                               
  AY386696 IGHA5*03 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --g ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   K   F   N   C   T   V   T   H   P   E       I   K   G   V   S   L   T   D 
  X82111   IGHA5*01 F  (CH2)    aca aag ttc aac tgc aca gtc acc cac cct gag ... ata aag ggc gtc tcc cta aca gac
  
  AF090367 IGHA5*02 F           
                                                                                     E       G                 
  AY386696 IGHA5*03 F           --- --- --- --- --- --- --- --- --- --- --- ... --- g-- --- -g- --- --- --- ---


                                                                                        
                                120 121 122 123 124 125 
                                 I   I   S   K   D   T  
  X82111   IGHA5*01 F  (CH2)    ata atc agc aaa gac aca 
  
  AF090367 IGHA5*02 F           
                                                        
  AY386696 IGHA5*03 F           --- --- --- --- --- --- 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   V   V   I   A   P   Q   V   H   L   L   P   P   P   S   D 
  X82111   IGHA5*01 F  (CH3)    ... ... ... ... ggt gtc gtc atc gcg ccc cag gtc cac ctg ctg cca ccg ccg tca gac
                                                                                                             E 
  AY386696 IGHA5*03 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --g --- --- --- --a


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X82111   IGHA5*01 F  (CH3)    gaa cta gcc ctg ... ... aac gcg ctg gtg acg ctg acc tgc ctg gtg cgg ggc ttc agc
                                                                                                               
  AY386696 IGHA5*03 F           --g --g --- --c ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   Y   W   T   N   K   G   V   E   V   P   K   D 
  X82111   IGHA5*01 F  (CH3)    ccc ... ... aag gat gtg ctg gtg tac tgg acg aac aaa ggc gtg gag gtc ccc aaa gac
                                                                                             A                 
  AY386696 IGHA5*03 F           --- ... ... --- --- --- --- --t --- --- --- --- --- --- --- -c- --- --- --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   F   L   V   W   K   P   L   P   E   P   G   Q   E               P   T 
  X82111   IGHA5*01 F  (CH3)    ... agc ttc ctg gtg tgg aag ccc ctg cct gag ccc ggc cag gaa ... ... ... ccc aca
                                     R   Y                                               D                     
  AY386696 IGHA5*03 F           ... --a -a- --- --- --- --- --- --- --- --- --t --- --- --c ... ... ... --- --c


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   A   V   T   S   L   L   R   V   P   A   E   D   W           N   Q   N 
  X82111   IGHA5*01 F  (CH3)    acc tac gct gtc acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag aat
                                                                                                               
  AY386696 IGHA5*03 F           --- --- --c --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   S   Y   T   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82111   IGHA5*01 F  (CH3)    gaa agc tac acc tgc gtg gta ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
                                                                                                               
  AY386696 IGHA5*03 F           --- --- --- --- --- --- --g --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                    ______________________________________CHS__                                
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  X82111   IGHA5*01 F  (CH3)    acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
                                                                                     Q                         
  AY386696 IGHA5*03 F           --- --- --- --- --- --- ... ... ... --- --- --- --- --a --- --- --- --- --- ---


                                ____________________________________                                
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   G   V   C   Y  
  X82111   IGHA5*01 F  (CH3)    gtg gca gac gtg gaa ggc gtg tgc tac 
                                                     A              
  AY386696 IGHA5*03 F           --- --- --- --- --- -c- --- --- --- 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 G   C   Q   E   P   L   P   C   V   V   L   D   L   P   Q   D   S   L   E   E 
  AY386696 IGHA5*03 F  (M)      ggt tgt cag gag ccc ctg ccc tgt gtg gtg ctg gat ctg cca cag gac agc ctg gag gag


                                
                                
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                 E   A   P   G   A   N   L   W   P   T   T   V   T   L   L   T   L   F   L   L 
  AY386696 IGHA5*03 F  (M)      gag gcc ccc ggc gcc aac ctg tgg ccc acc acc gtc acc ctc ctc act ctc ttc ctg ctg


                                
                                
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 S   L   F   Y   S   T   A   L   T   M   T   N   I   R   G   P   P   G   S   K 
  AY386696 IGHA5*03 F  (M)      agc ctg ttc tac agc aca gct ctg acc atg aca aac att cgg ggt cca cct ggc agc aaa


                                
                                
                                 61  62  63  64  65 
                                 E   G   P   Q   Y  
  AY386696 IGHA5*03 F  (M)      gag gga ccc cag tac