When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 A   S   A   T   T   P   G   I   Y   P   L   S   L   P   L   H 
  X82114   IGHA8*01 F  (CH1)    ... ... ... ... gcg tcc gca acc acc cca ggc atc tac ccg ctg agc ctc ccc cta cat


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 V   S   D   G   N       S   Q   P   V   V   V   G   C   L   I   D   G   F   F 
  X82114   IGHA8*01 F  (CH1)    gtg tca gat ggg aat ... tca cag ccc gtg gtc gtc ggc tgc ctg atc gat ggc ttc ttc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P   P       G   P   L   R   V   S   W   N   V   S   R   E   N   I   T         
  X82114   IGHA8*01 F  (CH1)    ccc ccg ... ggc cct ctg cgt gtg agc tgg aac gtc agc agg gag aat ata acc ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   V   Y   N   F   P   P   A   P   T   G   T   S                       G 
  X82114   IGHA8*01 F  (CH1)    ... agc gtc tat aac ttc cca cct gcc ccg act ggc act tca ... ... ... ... ... ggc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 P   Y   T   A   C   S   E   L   I   L   P   D   T   Q   C           L   R   H 
  X82114   IGHA8*01 F  (CH1)    ccg tac acc gca tgc agc gag ctg atc cta cca gac acg cag tgt ... ... ctt aga cat


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 Q   S   A   A   C   H   V   E   Y   N                   S   V   N   Q   S   L 
  X82114   IGHA8*01 F  (CH1)    caa agc gca gcc tgc cac gtg gaa tac aac ... ... ... ... tca gta aac cag agt ctg


                                                                                   
                                120 121 122 123 124 
                                 L   V   P   Y   P  
  X82114   IGHA8*01 F  (CH1)    ctt gtg ccc tac cca 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 D   C   C   P   A   N   S   C   C   T   C   P   S   S   S   S   R   N   L   I 
  X82114   IGHA8*01 F  (H)      gac tgc tgc cca gcc aac agc tgc tgc acc tgc ccc agc tcc agc tct aga aac ctc atc


                                
                                
                                 21  22 
                                 S   G  
  X82114   IGHA8*01 F  (H)      tca ggc 


                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                             C   Q   P   S   L   S   L   Q   R   P   D   I   G 
  X82114   IGHA8*01 F  (CH2)    ... ... ... ... ... ... ... tgc cag ccc agc ctg tcc ctg cag cgg cca gac atc ggg


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   L   L           G   R   D   A   S   L   T   C   T   L   S   G   L   K 
  X82114   IGHA8*01 F  (CH2)    gac ctg ctc ctg ... ... ggc cgg gac gcc agc ctc acc tgc acc ctg agc ggc ctg aag


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 D   P       E   G   A   V   F   T   W   E   P   T   N   G   N   E             
  X82114   IGHA8*01 F  (CH2)    gac ccc ... gag ggt gcc gtc ttc acc tgg gag ccc aca aac ggg aac gaa ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     P   V   Q   Q   R   A   Q   R   D   L   S   G                             
  X82114   IGHA8*01 F  (CH2)    ... ccc gtc cag cag aga gcc cag cgt gac ctc agt ggc ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 C   Y   S   V   S   S   V   L   P   S   S   A   E   T   W           K   V   R 
  X82114   IGHA8*01 F  (CH2)    tgc tac agt gtg tcc agt gtc cta ccc agc agt gcg gag acc tgg ... ... aaa gtg agg


                                                    _________________________FG_________________________                                      
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 T   E   F   T   C   T   V   T   H   P   E       I   E   G   G   S   L   T   A 
  X82114   IGHA8*01 F  (CH2)    aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gag ggc ggc tcc ctg aca gcc


                                                                                      
                                120 121 122 123 124 125 
                                 T   I   S   K   D   T  
  X82114   IGHA8*01 F  (CH2)    acc atc agc aaa gac aca 

                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   S   L   T   P   P   L   V   H   L   L   P   P   P   S   E 
  X82114   IGHA8*01 F  (CH3)    ... ... ... ... ggc agc ctc acc cca ccc ctg gtc cac ctg ctg ccg ccg ccg tca gaa


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 E   L   A   L           N   A   L   V   T   L   T   C   L   V   R   G   F   S 
  X82114   IGHA8*01 F  (CH3)    gag ttg gcc ctc ... ... aac gcg ctg gtg acg ctg acc tgc ctg gtg agg ggc ttc agc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   D   V   L   V   S   W   T   H   N   G   T   P   V   V   P   K 
  X82114   IGHA8*01 F  (CH3)    ccc ... ... aag gac gtg ctg gtg tcc tgg aca cac aac ggc acc cca gtg gtc ccc aaa


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 D   S   F   L   V   W   K   P   L   P   E   P   G   Q   D               P   T 
  X82114   IGHA8*01 F  (CH3)    gac agc ttc ctg gtg tgg aag ccc ctg ccc gag ccg ggc cag gac ... ... ... ccc acc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 

                                 T   Y   A   A   T   S   L   L   R   M   S   A   E   D   W           N   Q   G 
  X82114   IGHA8*01 F  (CH3)    acc tac gcc gcc acc agc ctg ctg cgc atg tcg gcc gag gac tgg ... ... aac cag ggg


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 D   S   Y   N   C   V   V   G   H   E   G       L   A   E   H   F   T   Q   K 
  X82114   IGHA8*01 F  (CH3)    gac agc tac aac tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag


                                                                    ______________________________________CHS__                               
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V   V 
  X82114   IGHA8*01 F  (CH3)    acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc


                                ____________________________________                               
                                140 141 142 143 144 145 146 147 148 
                                 V   A   D   V   E   G   V   C   Y  
  X82114   IGHA8*01 F  (CH3)    gtg gca gac gtg gaa ggc gtg tgc tac