When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                              
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 V   S   I   Q   A   P   S   V   F   P   L   A   S   C   C   R 
  AY386696 IGHE*01 F  (CH1)     ... ... ... ... gtc tct atc cag gcc ccc tcc gtc ttc ccc ttg gcc tcc tgc tgc aga


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 G   A   T   A   R       A   A   S   V   T   L   G   C   L   V   K   G   Y   F 
  AY386696 IGHE*01 F  (CH1)     ggg gcg act gcc agg ... gca gcc tcc gtg acg ctg ggc tgc ctg gtg aag ggc tac ttc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           E   P   V   S   V   T   W   D   A   G   T   L   N   S             
  AY386696 IGHE*01 F  (CH1)     ccg ... ... gag ccg gtg agc gtg acc tgg gat gcc ggc acc ctg aac agc ... ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     S   T   V   T   L   P   A   V   T   L   D   T                           G 
  AY386696 IGHE*01 F  (CH1)     ... agc acc gtg acc ttg cct gcc gtc acc ctc gac acg ... ... ... ... ... ... ggg


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   S   T   T   V   S   Q   V   T   I   S   G   A   W   A                   K 
  AY386696 IGHE*01 F  (CH1)     ctg tcc acc acc gtc agc cag gtg acc att tcg ggc gca tgg gct ... ... ... ... aag


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 Q   R   F   T   C   S   V   A   H   T   P   S   A   T   H   T   N   K   T   F 
  AY386696 IGHE*01 F  (CH1)     cag cgg ttc acc tgc agt gtg gca cac act ccg tct gca acc cac acc aac aag acc ttc


                                                                    
                                120 
                                 Q  
  AY386696 IGHE*01 F  (CH1)     caa 


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                     A   C   S   V   S   F   T   P   P   A   V   R   L   F   H   S   S   C   D 
  AY386696 IGHE*01 F  (CH2)     ... gcg tgc tct gtg agc ttc acc ccg ccg gcc gtg agg ctc ttc cac tcc tcc tgt gac


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 P   R   E   N           D   T   Y   T   V   Q   L   L   C   L   I   S   G   Y 
  AY386696 IGHE*01 F  (CH2)     ccc aga gag aac ... ... gac acc tac acc gtc cag ctt ctg tgc ctc atc tcc ggc tac


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 T       P   G   D   I   E   V   T   W   L   V   D   G   Q   K   D   P         
  AY386696 IGHE*01 F  (CH2)     acc ... ccg ggg gac atc gag gtc acc tgg ctg gtg gac ggg cag aag gac ccc ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 N   M   F   S   I   T   A   Q   P   R   Q   E   G                           K 
  AY386696 IGHE*01 F  (CH2)     aac atg ttc tcg atc acg gcg cag ccc agg cag gag ggc ... ... ... ... ... ... aag


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   A   S   T   H   S   E   L   N   I   T   Q   G   E   W           A   S   K 
  AY386696 IGHE*01 F  (CH2)     ctg gcg tcc acc cac agt gaa ctc aac atc acc cag ggc gag tgg ... ... gcg tcc aag


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 R   T   Y   T   C   R   V   A   Y   Q                   G   E   L   F   E   A 
  AY386696 IGHE*01 F  (CH2)     cgc acc tac acc tgc agg gtc gcc tac caa ... ... ... ... ggc gag ctc ttt gag gcc


                                                                                        
                                120 121 122 123 124 125 
                                 H   A   R   E   C   T  
  AY386696 IGHE*01 F  (CH2)     cac gcc cgg gag tgc aca 

                                                                                                                                               
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                             D   Y   E   P   R   G   V   S   T   Y   L   S   S   P   S   P   L 
  AY386696 IGHE*01 F  (CH3)     ... ... ... gat tac gaa ccg cga ggc gtg agc acc tac ctg agc tcc ccc agc ccc ctc


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   L   Y   V           H   K   S   P   K   L   T   C   L   V   V   D   L   A 
  AY386696 IGHE*01 F  (CH3)     gac cta tac gtc ... ... cac aag tcg ccc aag ctc acc tgc ctg gtg gtg gac ctg gcc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 S   E   E   G   V   S   L   V   W   S   R   D   S   G   K   P   V   D         
  AY386696 IGHE*01 F  (CH3)     agt gaa gag ggc gtg agc ctg gtc tgg tcc cgg gac agc ggg aag cct gtc gac ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                         P   D   P   W   K   S   D   K   Q   F   N                           A 
  AY386696 IGHE*01 F  (CH3)     ... ... cct gac ccc tgg aag tct gat aag cag ttc aat ... ... ... ... ... ... gcc


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   V   I   I   R   S   T   L   P   V   D   A   Q   D   W           I   D   G 
  AY386696 IGHE*01 F  (CH3)     acg gtc atc atc agg tcc acc ctg cca gtg gac gcc cag gac tgg ... ... att gat ggc


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   I   F   K   C   T   V   T   H   P   D           L   P   T   A   I   V   R 
  AY386696 IGHE*01 F  (CH3)     gag atc ttc aag tgc acc gtg acc cac cct gac ... ... ctg ccc aca gcc atc gtg cgc


                                                                                       
                                120 121 122 123 124 125 
                                 S   I   S   K   A   Q  
  AY386696 IGHE*01 F  (CH3)     tcc atc tcc aag gcc cag 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 G   K   R   A   T   P   E   V   H   L   F   T   P   P   E   E 
  AY386696 IGHE*01 F  (CH4)     ... ... ... ... ggc aag cgt gcc acc cct gag gtc cac ctg ttc aca ccg cct gag gag


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   Q   G   S           R   D   Q   L   T   L   T   C   L   V   Q   N   F   F 
  AY386696 IGHE*01 F  (CH4)     gat cag ggg agc ... ... agg gac cag ctc acc ctc acc tgc ctg gtc cag aac ttc ttc


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           A   D   I   F   V   D   W   L   R   N   G   Q   H   M   P   S     
  AY386696 IGHE*01 F  (CH4)     cca ... ... gcg gac atc ttc gtg gac tgg ctg cgc aat ggc cag cac atg ccc agt ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 G   Q   Q   S   T   T   E   P   R   L   A   G   G   S                   N   Q 
  AY386696 IGHE*01 F  (CH4)     ggc cag caa agc acc acc gag cct cgc ctg gct ggc ggc tcc ... ... ... ... aac caa


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   F   V   F   S   R   L   E   V   S   R   A   D   W           E   Q   N 
  AY386696 IGHE*01 F  (CH4)     acc tac ttt gtc ttc agc cgc ctg gag gtc agc cgg gct gac tgg ... ... gag cag aac


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 I   P   F   T   C   R   V   V   H   E   A   V   T   D   T   R   T   L   L   K 
  AY386696 IGHE*01 F  (CH4)     atc cca ttc acc tgc cgc gtg gtc cac gag gcg gtg acc gac acc agg acc ctg ctg aaa


                                                                    __CHS__                                
                                120 121 122 123 124 125 126 127 128 129 130 
                                 T   V   S   K   R   P               G   K  
  AY386696 IGHE*01 F  (CH4)     acc gtg tcc aag agg ccc ... ... ... ggt aaa 

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 E   L   D   V   Q   D   L   C   T   E   G   A   E   H   E   E   L   D   G   L 
  AY386696 IGHE*01 F  (M1)      gag ctg gac gtc cag gac ctg tgc aca gag ggg gct gag cac gag gag cta gac gga ctg


                                
                                
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                 W   T   S   T   C   I   F   A   G   L   F   L   L   S   T   S   C   S   A   T 
  AY386696 IGHE*01 F  (M1)      tgg acc agc acc tgc atc ttc gcc ggc ctc ttc ctg ctc agt acg agc tgc agc gcc acc


                                
                                
                                 41  42  43  44  45   
                                 V   L   L   L   K    
  AY386696 IGHE*01 F  (M1)      gtc ctg ctc ctc aag 


                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 V   K   W   V   F   T   A   V   L   R   E   S   P   Q   A   S   H   D   Y   T 
  AY386696 IGHE*01 F  (M2)      gtg aag tgg gtc ttc aca gcg gtg ctg cgg gag tcg ccc caa gcc tcc cac gac tac acc


                                
                                
                                 21  22  23  24  25  26  27 
                                 N   V   L   Q   L   R   A  
  AY386696 IGHE*01 F  (M2)      aac gtc ctc cag ctg cgg gcc