When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).


                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 V   S   L   S   S   P   T   L   Y   P   L   V   S   C   E   G 
  J00666   IGHM*01 F  (CH1)     ... ... ... ... gtg agc ctg tca tct cca act ctg tac ccg ctc gtc tcc tgc gag ggt
                                                                                                               
  AY386695 IGHM*02 F            ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 A   L   T   D           G   N   L   V   A   M   G   C   L   A   R   D   F   L 
  J00666   IGHM*01 F  (CH1)     gcc ctg acc gat ... ... ggg aac ctg gtg gcc atg ggc tgc ctg gcg cgg gac ttt ctg
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           S   S   V   T   F   S   W   S   F   K   N   N   S   E   I   S   S 
  J00666   IGHM*01 F  (CH1)     ccc ... ... agc tcc gtc acc ttc tcc tgg agc ttc aag aac aac tct gag atc agc agc
                                                                                                               
  AY386695 IGHM*02 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                 R   T   V   R   T   F   P   V   V   K   R   G   D                             
  J00666   IGHM*01 F  (CH1)     cgg acc gtc agg acc ttc ccg gtg gtg aag aga ggg gac ... ... ... ... ... ... ...
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 K   Y   M   A   T   S   Q   V   L   V   P   S   K   D   V   L   Q   G   T   E 
  J00666   IGHM*01 F  (CH1)     aag tat atg gcc acc tcg cag gtg ctg gtg ccc tcc aag gat gtc ctc cag ggc aca gag
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   Y   L   V   C   K   V   Q   H   S                   N   S   N   R   D   L 
  J00666   IGHM*01 F  (CH1)     gag tac ctg gtg tgc aaa gtc cag cac agc ... ... ... ... aac agc aac aga gac ctg
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                                    
                                120 121 122 123 124 
                                 R   V   S   F   P  
  J00666   IGHM*01 F  (CH1)     cga gtg tcc ttt ccc 
                                                    
  AY386695 IGHM*02 F            --- --- --- --- --- 
                                                    
  AY386696 IGHM*02 F            --- --- --- --- --- 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                             V   D   S   E   L   P   P   N   V   S   V   F   I   P   P   R   D 
  J00666   IGHM*01 F  (CH2)     ... ... ... gtg gac tca gag ctg ccc ccc aac gtg agc gtg ttc atc cca cct cga gac
                                                                                                               
  AY386695 IGHM*02 F            ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 S   F   S   G   S   G   T   R   K   S   R   L   I   C   Q   A   T   G   F   S 
  J00666   IGHM*01 F  (CH2)     tcc ttc agc ggc tct ggc aca cgc aag tcc agg ctc atc tgc cag gcc aca ggt ttc agc
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           K   Q   I   S   V   S   W   L   R   D   G   Q   K   V   E   S     
  J00666   IGHM*01 F  (CH2)     ccc ... ... aaa cag atc agc gtg tcc tgg ctg cgc gat ggg cag aag gtg gag tct ...
                                                                                                               
  AY386695 IGHM*02 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
                                                                                                               
  AY386696 IGHM*02 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     G   V   L   T   K   P   V   E   A   E   T   K   G   A           G   P   A 
  J00666   IGHM*01 F  (CH2)     ... ggc gtc ctc acc aag ccg gtg gag gct gaa acc aaa ggg gct ... ... ggg cct gcg
                                                                                                               
  AY386695 IGHM*02 F            ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   F   S   I   S   S   M   L   T   I   T   E   S   D   W           L   S   Q 
  J00666   IGHM*01 F  (CH2)     acc ttt agc atc agc agc atg ctg acc atc acc gag agc gac tgg ... ... ctg agc cag
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 S   L   Y   T   C   R   V   D   H   R                   G   I   F   F   D   K 
  J00666   IGHM*01 F  (CH2)     agc ctg tac acc tgc cgc gtg gac cac agg ... ... ... ... ggc atc ttc ttc gat aag
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---


                                                                                                    
                                120 121 122 123 124 125 126 127 128 
                                 N   V   S   M   S   S   E   C   S  
  J00666   IGHM*01 F  (CH2)     aac gtg tcc atg tcc tcc gag tgc agc 
                                                                    
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- 
                                                                    
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 T   P   S   P   G   I   Q   V   F   P   I   A   P   S   F   A 
  J00666   IGHM*01 F  (CH3)     ... ... ... ... acc cca tcc cca ggc atc cag gtc ttc ccc atc gcc cct tcg ttc gcc
                                                                                                               
  AY386695 IGHM*02 F            ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                                               
  AY386696 IGHM*02 F            ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 D   T   F   L           S   K   S   A   R   L   I   C   L   V   T   D   L   T 
  J00666   IGHM*01 F  (CH3)     gac acc ttc ctc ... ... agc aag tca gcc agg ctg atc tgc ctg gtc aca gac ctg acc
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 T   Y       G   S   L   N   I   S   W   A   S   H   N   G   K   A   L         
  J00666   IGHM*01 F  (CH3)     acc tat ... ggc agc ctc aac atc tcc tgg gca agc cat aac ggc aaa gcc ctg ... ...
                                                                                                               
  AY386695 IGHM*02 F            --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                               
  AY386696 IGHM*02 F            --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     D   T   H   M   N   I   T   E   S   H   P   N                           A 
  J00666   IGHM*01 F  (CH3)     ... gac acc cac atg aac atc acc gag agc cac ccc aac ... ... ... ... ... ... gcc
                                                                                                               
  AY386695 IGHM*02 F            ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                               
  AY386696 IGHM*02 F            ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   F   S   A   M   G   E   A   S   V   C   A   E   D   W           E   S   G 
  J00666   IGHM*01 F  (CH3)     acc ttc agc gcc atg ggc gag gcc agc gtg tgc gcg gag gat tgg ... ... gag tct ggg
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                        
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   Q   F   T   C   T   V   T   H   A   D           L   P   F   P   L   K   H 
  J00666   IGHM*01 F  (CH3)     gag cag ttc acg tgc acc gtg acc cac gcc gac ... ... ctg ccc ttc ccg ctg aag cac
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                                                        
                                120 121 122 123 124 125 
                                 T   I   S   K   S   R  
  J00666   IGHM*01 F  (CH3)     acc atc tcc aag tcc agg 
                                                        
  AY386695 IGHM*02 F            --- --- --- --- --- --- 
                                                        
  AY386696 IGHM*02 F            --- --- --- --- --- --- 

                                                                                                                                                
                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                             E   V   A   K   H   P   P   A   V   Y   V   L   P   P   A   R   E 
  J00666   IGHM*01 F  (CH4)     ... ... ... gag gtg gcc aag cac ccc ccg gcg gtg tac gtg ctg ccg cca gcc cgg gag
                                                                                                               
  K01357   IGHM*01 F            ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386695 IGHM*02 F            ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 Q   L   V   L           R   E   S   A   T   V   T   C   L   V   K   G   F   S 
  J00666   IGHM*01 F  (CH4)     cag ctg gtc ctg ... ... cga gag tcg gcc acc gtg acc tgc ctg gtc aag ggc ttc tcg
                                                                                                               
  K01357   IGHM*01 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                _______BC___________________                            _____________CD_________
                                                                                        45.1    45.3    45.5    
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P           A   D   V   F   V   Q   W   Q   Q   R   G   Q   P   L   S   S   D 
  J00666   IGHM*01 F  (CH4)     ccg ... ... gca gat gtg ttc gtg cag tgg cag cag agg ggg cag ccc ttg tcc tca gac
                                                                                                               
  K01357   IGHM*01 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386695 IGHM*02 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5    
                                     K   Y   V   T   S   A   P   A   P   E   P   Q   A                   P   G 
  J00666   IGHM*01 F  (CH4)     ... aag tac gtg acc agc gcc cca gcg ccc gag ccc cag gcc ... ... ... ... cca ggc
                                                                                                               
  K01357   IGHM*01 F            ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
                                                                                                               
  AY386695 IGHM*02 F            ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
                                                                                                               
  AY386696 IGHM*02 F            ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---


                                ____________                                                ___EF___            
                                    85.2                                                    96.1                
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 L   Y   F   T   H   S   T   L   T   V   T   E   E   D   W           N   S   G 
  J00666   IGHM*01 F  (CH4)     ctg tac ttc acc cac agc acc ctg acc gtg acc gag gag gac tgg ... ... aac tcc ggg
                                                                                                               
  K01357   IGHM*01 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                    _________________________FG_________________________                                       
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 E   T   F   T   C   V   V   G   H   E   A       L   P   H   M   V   T   E   R 
  J00666   IGHM*01 F  (CH4)     gag acg ttc acc tgc gtc gtg ggc cac gag gcc ... ctg ccg cac atg gtg acc gag agg
                                                                                                               
  K01357   IGHM*01 F            --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---


                                                                    ______________________________________CHS__                                
                                120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 
                                 T   V   D   K   S   T               G   K   P   T   L   Y   N   V   S   L   I 
  J00666   IGHM*01 F  (CH4)     acc gtg gac aag tcc act ... ... ... ggt aaa ccc acc ttg tac aat gtg tcc ctg atc
                                                                                                               
  K01357   IGHM*01 F            --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386695 IGHM*02 F            --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AY386696 IGHM*02 F            --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---


                                ____________________________________                                
                                140 141 142 143 144 145 146 147 148 
                                 M   S   D   T   A   S   T   C   Y  
  J00666   IGHM*01 F  (CH4)     atg tct gac acg gcc agc acc tgc tac 
                                                                    
  K01357   IGHM*01 F            --- --- --- --- --- --- --- --- --- 
                                                                
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --
                                                                
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --

                                
                                
                                 1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20 
                                 E   G   E   V   G   A   E   E   E   G   F   E   N   L   W   T   T   A   S   T 
  K01357   IGHM*01 F  (M1)      gaa ggg gag gta ggc gcc gag gag gag ggc ttt gag aac ctg tgg acc acc gcc tcc acc
                                                                                                              
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                              
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                
                                
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39 
                                 F   I   V   L   F   L   L   S   L   F   Y   S   T   T   V   T   L   F   K  
  K01357   IGHM*01 F  (M1)      ttc atc gtc ctg ttc ctg ctg agc ctc ttc tac agc acc acg gtc act ctg ttc aag 
                                                                                                            
  AY386695 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 
                                                                                                            
  AY386696 IGHM*02 F            --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- 


                                
                                
                                 1   2  
                                 V   K  
  K01357   IGHM*01 F  (M2)      gtg aag 
                                        
  AY386695 IGHM*02 F            --- --- 
                                        
  AY386696 IGHM*02 F            --- ---