When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).



                                1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                 X   D   P   V   A   P   T   V   L   I   F   P   P   A   A   D 
  K01360   IGKC1*01 F           ... ... ... ... ngt gat cca gtt gca cct act gtc ctc atc ttc cca cca gct gct gat
                                                                                                               
  X00231   IGKC1*01 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                     S         
  K01362   IGKC1*02 F           ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- t-- --- ---
                                                     A   T   L                                       S   P   A 
  K01363   IGKC1*03 F           ... ... ... ... -t- -c- a-- t-g --- --- --- --- --- --- --- --- --- t-- c-- -c-
                                             X   D   P       I                       L               S         
  X00674   IGKC1*04 F           ... ... ... ngt ga- cc- --- a-- --g --- --- --- --- c-- --- --- --- t-- --- ---
                                             X   D   P       I                       L               S         
  X03050   IGKC1*05 ORF (1)     ... ... ... ngt ga- cc- --- a-- --g --- --- --- --- c-- --- --- --- t-- --- ---
                                                     A   T   L                                       S   P   A 
  M37809   IGKC1*06 F           ... ... ... ... -t- -c- a-g t-g --- --- --- --- --- --- --- --- --- t-- c-- -c-
                                                                                                     S   P   A 
  M22542   IGKC1*07 F           ... ... ... ... -t- --- --- --- --- --- --- --- --- --- --- --- --- t-- c-- -c-
                                                                                                     S   P   A 
  Z48308   IGKC1*08 F           ... ... ... ... -t- --- --- --- --- --- --- --- --- --- --- --- --- t-- c-- -c-
                                             C   D   P       I                       L               S         
  K01359   IGKC1*09 (F) (cDNA)  ... ... ... tgt ga- cc- --- a-- --g --- --- --- --- c-- --- --- --- t-- --- ---


                                            _____AB_____                                            ____________
                                            15.1    15.3                                                        
                                 13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                 Q   V   A               T   G   T   V   T   I   V   C   V   A   N   K   Y   F 
  K01360   IGKC1*01 F           cag gtg gca ... ... ... act gga aca gtc acc atc gtg tgt gtg gcg aat aaa tac ttt
                                                                                                               
  X00231   IGKC1*01 F           --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                 L                                                                             
  K01362   IGKC1*02 F           -tt --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                 E   L                               A                                         
  K01363   IGKC1*03 F           g-- c-- --- ... ... ... --- --- --- -c- --- --- --- --c --- --a --c --- --- ---
                                     L   T                   E                                           F   R 
  X00674   IGKC1*04 F           --- c-- a-- ... ... ... --- -a- --- --- --- --- --- --c --- --a --- --- -t- cg-
                                     L   T                   E                                           F   R 
  X03050   IGKC1*05 ORF (1)     --- c-- a-- ... ... ... --- -a- --- --- --- --- --- --c --- --a --- --- -t- cg-
                                 E   L                               A                                         
  M37809   IGKC1*06 F           g-- c-- --- ... ... ... --- --- --- -c- --- --- --- --c --- --- --- --- --- ---
                                 E   L                               A                                         
  M22542   IGKC1*07 F           g-- c-- --- ... ... ... --- --- --- -c- --- --- --- --c --- --- --- --- --- ---
                                 E   L                               A                                         
  Z48308   IGKC1*08 F           g-- c-- --- ... ... ... --- --- --- -c- --- --- --- --c --- --- --- --- --- ---
                                     L   T                   E                                           F   R 
  K01359   IGKC1*09 (F) (cDNA)  --- c-- a-- ... ... ... --- -a- --- --- --- --- --- --c --- --a --- --- -t- cg-


                                ___________BC______________                             _____________CD_________
                                                                                        45.1    45.3    45.5        
                                 30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                 P               D   V   T   V   T   W   E   V   D   G   T   T   Q   T   T     
  K01360   IGKC1*01 F           ccc ... ... ... gat gtc acc gtc acc tgg gag gtg gat ggc acc acc caa aca act ...
                                                                                                               
  X00231   IGKC1*01 F           --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
                                                                                                               
  K01362   IGKC1*02 F           --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
                                                     G                   Q               K   P   L             
  K01363   IGKC1*03 F           --- ... ... ... --- -g- --- --- --- --- c-- --- --- --- -ag c-- -t- --- --- ...
                                             N       I                   K           V   E   I       Q   S     
  X00674   IGKC1*04 F           --- ... ... aat --c a-- --- --- --- --- a-- --- --- -t- gaa -t- --- cag -gc ...
                                             N       I                   K           D   E   I       Q   S     
  X03050   IGKC1*05 ORF (1)     --- ... ... aat --c a-- --- --- --- --- a-- --- --- -a- gaa -t- --- cag -gc ...
                                                     G                   K               I           S   S     
  M37809   IGKC1*06 F           --- ... ... ... --- -g- --- --- --- --- a-- --- --- --- -t- --- --- -gc -gc ...
                                                                         K                                     
  M22542   IGKC1*07 F           --- ... ... ... --- --- --- --- --- --- a-- --- --- --- --- --- --- --- --- ...
                                                     G                   K               I           S   S     
  Z48308   IGKC1*08 F           --- ... ... ... --- -g- --- --- --- --- a-- --- --- --- -t- --- --- -gc -gc ...
                                             N       I                   K           D   E   I       Q   S     
  K01359   IGKC1*09 (F) (cDNA)  --- ... ... aat --c a-- --- --- --- --- a-- --- --- -a- gaa -t- --- cag -gc ...


                                ____                                ___________________________DE_______________
                                45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                     77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5        
                                     G   I   E   N   S   K   T   P   Q   N   S   A   D                       C 
  K01360   IGKC1*01 F           ... ggc atc gag aac agt aaa aca ccg cag aat tct gca gat ... ... ... ... ... tgt
                                                                                                               
  X00231   IGKC1*01 F           ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
                                                                                                               
  K01362   IGKC1*02 F           ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
                                                 T                               D                             
  K01363   IGKC1*03 F           ... --- --- --- -c- --- --- --- --- --- --- --- -at --- ... ... ... ... ... ---
                                                         T               S   P   E                             
  X00674   IGKC1*04 F           ... --- --- --- --- --- -c- --- --- --- -gc c-c -a- --c ... ... ... ... ... ---
                                                         T               S   P   E                             
  X03050   IGKC1*05 ORF (1)     ... --- --- --- --- --- -c- --- --- --- -gc c-c -a- --c ... ... ... ... ... ---
                                             N           R                                                     
  M37809   IGKC1*06 F           ... --- --- a-t --- --- -g- --- --- --- --- --- --- --- ... ... ... ... ... ---
                                                         R                       D                             
  M22542   IGKC1*07 F           ... --- --- --- --- --- -g- --- --a --- --- --- -at --- ... ... ... ... ... ---
                                             N           R               D   P   T   Y                         
  Z48308   IGKC1*08 F           ... --- --- a-t --- --- -g- --- --- --- g-- c-- a-- t-- ... ... ... ... ... ---
                                                         T               S   P   E                             
  K01359   IGKC1*09 (F) (cDNA)  ... --- --- --- --- --- -c- --- --- --- -gc c-c -a- --c ... ... ... ... ... ---


                                ____________                                                ___EF___    
                                    85.2                                                    96.1        
                                85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                 T   Y   N   L   S   S   T   L   T   L   T   S   T   Q   Y           N   S   H 
  K01360   IGKC1*01 F           acc tac aac ctc agc agc act ctg aca ctg acc agc aca cag tac ... ... aac agc cac
                                                                                                               
  X00231   IGKC1*01 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                               
  K01362   IGKC1*02 F           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                         K       D   E                         
  K01363   IGKC1*03 F           --- --- --- --- --- --t --- --- --- --- -aa --- gac g-- --- ... ... --- --- ---
                                                                 S           K   A                             
  X00674   IGKC1*04 F           --- --- --- --- --- --- --- --- t-- --- --- -aa g-- --- --- ... ... --- --- ---
                                                                 S           K   A                             
  X03050   IGKC1*05 ORF (1)     --- --- --- --- --- --- --- --- t-- --- --- -aa g-- --- --- ... ... --- --- ---
                                                                         S       D   E                         
  M37809   IGKC1*06 F           --- --- --- --- --- --t --- --- --- --- -g- --- gac g-- --- ... ... --- --- ---
                                                                         K       D   E                         
  M22542   IGKC1*07 F           --- --- --- --- --- --t --- --- --- --- -aa --- gac g-- --- ... ... --- --- ---
                                                                         S       D   E                         
  Z48308   IGKC1*08 F           --- --- --- --- --- --t --- --- --- --- -g- --- gac g-- --- ... ... --- --- ---
                                                                 S           K   A                             
  K01359   IGKC1*09 (F) (cDNA)  --- --- --- --- --- --- --- --- t-- --- --- -aa g-- --- --- ... ... --- --- ---


                                                    _________________________FG________________________
                                
                                100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                 K   E   Y   T   C   K   V   T   Q   G                   T   T   S   V   V   Q 
  K01360   IGKC1*01 F           aaa gag tac acc tgc aag gtg acc cag ggc ... ... ... ... acg acc tca gtc gtc cag
                                                                                                               
  X00231   IGKC1*01 F           --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                                                                                                               
  K01362   IGKC1*02 F           --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
                                 D                   Q       A                       S   G   S   P             
  K01363   IGKC1*03 F           g-c --- --- --- --- c-- --- g-- --- --- ... ... ... tca ggc t-a c-g --- --- ---
                                 S   V               E       V   H   N               S   G   S   A   I         
  X00674   IGKC1*04 F           -gc -t- --- --- --- g-- --- gt- --c aa- ... ... ... tcg ggc t-a g-g a-- --- ---
                                 S   V               E       V   H   N               S   G   S   A   I         
  X03050   IGKC1*05 ORF (1)     -gc -t- --- --- --- g-- --- gt- --c aa- ... ... ... tcg ggc t-a g-g a-- --- ---
                                 D                   Q       A       D               S   G   S   P             
  M37809   IGKC1*06 F           g-c --- --- --- --- c-- --- g-- --- -a- ... ... ... tca ggc t-a c-g --- --- ---
                                 D           I       Q       A                       S   G   S   P             
  M22542   IGKC1*07 F           g-c --- --- -t- --- c-- --- g-- --- --- ... ... ... tca ggc t-a c-g --- --- ---
                                 N                   Q       A       D               S   G   S   P             
  Z48308   IGKC1*08 F           --c --- --- --- --- c-- --- g-- --- -a- ... ... ... tca ggc t-a c-g --- --- ---
                                 S   V               E       V   H   N               S   G   S   A   I         
  K01359   IGKC1*09 (F) (cDNA)  -gc -t- --- --- --- g-- --- gt- --c aa- ... ... ... tcg ggc t-a g-g a-- --- ---


                                
                                
                                120 121 122 123 124 125 126 
                                 S   F   N   R   G   D   C  
  K01360   IGKC1*01 F           agc ttc aat agg ggt gac tgt 
                                                            
  X00231   IGKC1*01 F           --- --- --- --- --- --- --- 
                                                            
  K01362   IGKC1*02 F           --- --- --- --- --- --- --- 
                                         S       K   N      
  K01363   IGKC1*03 F           --- --- -g- --- aag a-- --- 
                                                            
  X00674   IGKC1*04 F           --- --- --- --- --- --- --- 
                                                            
  X03050   IGKC1*05 ORF (1)     --- --- --- --- --- --- --- 
                                         S       K   S      
  M37809   IGKC1*06 F           --- --- -g- --- aag ag- --- 
                                         S       K   N      
  M22542   IGKC1*07 F           --- --- -g- --- aag a-- --- 
                                                 K   S      
  Z48308   IGKC1*08 F           --- --- --- --- aag ag- --- 
                                                            
  K01359   IGKC1*09 (F) (cDNA)  --- --- --- --- --- --- --- 

IMGT note:
(1) The strain is Basilea. ORF because of non canonical ACCEPTOR-SPLICE sequence: naann instead of nagnn.