Only the *01 allele of each functional, ORF and in-frame pseudogene V-REGION is shown.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
Dots indicate gaps according to the IMGT unique numbering. Blanks at the 5' and/or 3' end indicate partial sequences.
Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.
____________________________________________________________________________________________________________________________________________________ IGHV FR1-IMGT CDR1-IMGT FR2-IMGT CDR2-IMGT FR3-IMGT CDR3-IMGT gene (1-26) (27-38) (39-55) (56-65) (66-104) (105-115) ___________________________ __________________________ ____________ _________________ __________ _______________________________________ ___________ 1 10 20 30 40 50 60 70 80 90 100 110 .........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|..... #c AF094531,IGHV1S1 GQTLTESEP.VTKRPGESHRLTCTAS GFTFSSYW.... MAWVRQAPGKGLEWVAS MYNSDNI... FYSESVK.GRFSISRDDNRQQVSLQMSSLTAVDSAVYYC AR #c AF303538,IGHV1S2 GQTLTESDS.VTKRPGESHRLTCTAS GFTFSSST.... LAWVRQAPGKGLEWVLD HLMAVAAS.. TTLKSSE.GRFTISRDNNRQQVSLQMNSLTAVDSAVYYC AR #c AF303558,IGHV1S3 RPGESHRLTCTAS GFTFSSYY.... MAWVRQAPGKGLEWVAL IHLMAVAAS. TTLRSVE.GRFTISRDNNRQQVSLQMNSLTAVDSAVYYC AR #c AF303540,IGHV1S4 GQTLTESEP.VTKRPGESHRLTCTAS GFTFSSHW.... MAWVRQAPGKGLEWIAL IHPTSSSSSI YYSESVK.GRFTISRDNNIQQLYLQMSSLTAVDSAVYYC AR #c AF303555,IGHV1S5 GQTLTESDS.VTKRPGESHRLTCTAS GFTFSSYY.... MHWIRQAPGKGLEWIAY ISNGGGGTQ. YYSESVK.GRFTISRDNSRQQVYLQMNSLKAEDTAVYYC AR #c AF303565,IGHV1S6 GQTLTESDS.VTKRPGESHRLTCTAS GFTFSTYW.... MAWVRQAPGKGLEWIAF IHPSSSSAHI YYSESVK.GRFTISRDNSRQQLYLQMSSVTAVDSAVYYC AR #c AF303563,IGHV1S7 GQTLTESDS.VTKRPGEPHRLTCTAS GFTFSDYR.... MNWVRQAPGKGLEWIAF IHPTSSSSI. YYSESVK.GRFTISRDNNRQQVYLQMNSLTAVDSAVYYC AR #c AF303550,IGHV1S8 GQTLTESEP.VTKRPGESHMLTCTAS GFTFSSYE.... INWVRQAPGKGLEWIAI ISSGSGSTK. YYSDSVK.GRFSISRDNNRQQLYLQMSSLTAVDSAVYYC AR #c AF303561,IGHV1S9 GQTLTESEP.VTKRPGESHRLTCTAS GFTFSSHW.... MAWVRQAPGKGLEWIAL IHPTSSNSSI YYSESVK.GRFTISRDNNIQQLYLQMSSLTAVDSAVYYC AR #c AF303564,IGHV1S10 GQTLTESEP.VTKRPGESHRLTCTAS GFTFSSHW.... MAWVRQAPGKGLEWVAT ISDSSSSI.. YYSESVK.GRFTISRDNNIQQLYLQMSSLTAVDSAVYYC AR #c AF303562,IGHV1S11 GQTLTESEP.VTKRPGESHRLTCTGS GFTFSSHW.... MAWVRQAPGKGLEWIAL IHPTSSSYI. YYSESVK.GRFTISRDNSRQQVSLQMSSLTAVDSAVYYC AR #c AF303569,IGHV1S12 GQTLTESEP.VTKRPGESHRLTCTAS GFTLSSYW.... MAWVRQAPGKGLEWIAL IHPTSSSSS. YYSESVK.GRFTISRDNNRQQVYLQMNSLTAVDSAVYYC AR #c AF303541,IGHV1S13 GQTLTESEP.VTKRPGESHRLTCTTS GFTFSSYW.... MAWVRQAPGKGLEWIRL IHPTTSSSI. YYSESVK.GRFTGSN.NNIQQVYLQMNSLTAVDSAVYYC AR #c AF303552,IGHV1S14 EP.VTKRPGESHRLTCTTS GFTFNHY..... IAWIRQAPGKGLEWIAL IHPTSRANI. FYSESVK.GRFIGSS.NNIQQVYLQMNSLTAVDSAVYYC AR #c AF303544,IGHV1S15 GQTLTESEP.VTKRPGESHRLTCTGS GFTFSSHW.... MNWVRQAPGKGLEWIRL IHYSSSYI.. YYSESVKGRFTISRDNNNRQQVSLQMNSLTAVDSAVYYC AR #c AF303556,IGHV1S16 GQTLTESDP.VTKRPGESHRLTCTAS GFTFTSYY.... MAWVRQAPGKGLEWVAT ITNGGSTP.. YYSESFK.GRFTISRDNNRQQVSLQMNSLTAVDSAVYYC AR #c AF303553,IGHV1S17 KRPGESHRLTCTAS GFTFTSYN.... MAWVRQAPGKGLEWVTY INTGSTP... YYFESFK.GRFTISRDNNRQQVSLQMNSLTAVDSAVYYC AR #c AF303548,IGHV1S18 TESEP.VTKRPGESHRLTCTAS GFTFSDYY.... MAWVRQAPGKGLEWIAL IHPTTSTYI. SSSESSE.GRFTISRDNTRQQVSLQMNSLTAVDSAVYYC AR #c AF303559,IGHV1S19 LSSYW.... MAWVRQAPGKGLEWIAY NDNGGTTK.. YYSESVK.GRFTISRDNSRQQLYLQMSSLTAVDSAVYYC AR #c AF303547,IGHV1S20 GSKQ... FYSESVK.GRFTISRDNSRQQLYLQMSSLTAVDSAVYYC AR #c AF303551,IGHV2S1 GQTLTESDP.VTKRPGESHRLTCTAS GFTFSSYG.... MNWIRQAPGKGLEWIAY IHSTSI.... YYSQSVQ.GRFTISRDDSSSKVYLQMNSLEAEDTAVYYC AR #c AF303572,IGHV2S2 GQTLTESDP.VTKRPGESHRLTCTAS GFTFSPYRD... EAWVRQAPGKGLEWIAY ISTASSPI.. YYSQSVQ.GRFTISRDDSSSKVYLQMNSLKAEDTAVYYC AR #c AF303534,IGHV2S3 GESHRLTCTAS GFTFSDYY.... MHWIRQAPGKGLEWIAI IGTSSSPI.. RYSQSVQ.GRFTISRDDSAVKKYLQMNSLKAEDTAVYYC AR #c AF303539,IGHV2S4 MNWVRQAPGKGLEWIAF IHTGSTST.. SYSQSVQ.GRFTISRDDSSSKVYLQMNSLKAEDTAVYYC AR #c AF303571,IGHV3S1 CEQLIQPAS.VTVQPGQRLPITCQVS YSVSSYN..... TAWIRQPAGKGLEWIGM AAAGSTT... HFKDSLK.SKFSIDLDSSSKTVTLNGQSMQPGDSAVYYC AR #c AF303570,IGHV3S2 IQPAS.VTVQPGQRLTITCQVS YSVSSYY..... TAWIRQPAGKGLEWIGM RQGSTT.... YYKDSLK.SKFSIDLDSSSKTVTLNGQSVQPGDSAVYYC AR #c AF303537,IGHV3S3 CEQLIQPAS.VTVQPGQRLTITCQVS YSVSSAY..... TAWIRQPAGKGLEWIGM KYTSGT.... HYKDSLK.SKFSIDLDSSSNTVTLNGQSVQPGDSAVYYC AR #c AF303543,IGHV3S4 CEQLTQPAS.VTVQPGQRLTITCQVS YLWQSS...... YHWIRQPAGKGLEWISR TWLDTPQ... SEKDSLK.SKFSIDLDSSSNTVTLNGQSMQPGDSAVYYC AR #c AF303535,IGHV3S5 CEQLIQPAS.VTVQPGQRLTITCQVS YSLGSF...... TAWIRQPAGKGLEWIGV KHWSS..... SYKDSLK.TKFSIDLDSSSNTVTLNGQSVQPGDSAVYYC AR#c: rearranged cDNA
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
Created: 28/02/2002
Last updated: Monday, 11-Jul-2011 12:57:00 CEST
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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