The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
X15045 ,IGHA1 (A)SPTSPKVFPLSLCSTQP....DGDVVVACLVQ GFFPQ.EPLS VTWSESGQGV....TARNFPPSQDASG.....DLYTTSSQLTLPATQC..PDGKSVTC HVKHY...TNPSQ DVTVPCR
X53707 ,IGHA2 (A)SPTSPKVFPLSLDSTQP....DGNVVVACLVQ GFFPQ.EPLS VTWSESGQNV....TVRNFPPSQDASG.....DLYTMSSQLTLPATQC..PDCKSVTC HVNHY...TNSSQ DVTVPCR
AF300449,IGHG1 AVLQSS......GLYSLSSVVTVPSSSL...GTQTYIC NVNHKP..SNTKV DKKV
AF300448,IGHG2 AVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVDHKP..SNTKV DKRV
AF300447,IGHG3 AVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVNHKP..SNTKV DKRV
AF300446,IGHG4 AVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVDHKP..SSTKV DKRV
AF300445,IGHGP AVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVDHKP..SNTKV DKRV
CH2
X15045 ,IGHA1 (1) CCHPRLSLHRPALEDLLL..GSEANLTCTLT GLRDA.SGVT FTWTPSSGKS....AVEGPPERDLCG.......CYSVSSVLPGCAEPW..NHGKTFTC TAAYPE..SKTPL TATLSKS
X53707 ,IGHA2 (1) CCHPRLSLHRPALEDLLL..GSEANLTCTLT GLRDA.SGAT FTWTPSSGKS....AIQGPPERDLCG.......CYSVSSVLPGCAEPW..KNGKTFTC TAAHPE..SKTPL TANITKS
AF300449,IGHG1 (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTC
AF300448,IGHG2 (A)PPVAGPSVFLFPPKPKDTLMI.SRTPEVTC
AF300447,IGHG3 (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTC
AF300446,IGHG4 (A)PEFLGGPSVFLFPPKPKDTLMI.SRTPEVTC
AF300445,IGHGP (A)TEPLGGPSVFVFPPKPKDTLMI.SRTPEVTC
CH3
X15045 ,IGHA1 (G)NMFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..KDVL VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
X53707 ,IGHA2 (G)NMFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..KDVL VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
Hinge
X15045 ,IGHA1*01 (V)PSTPPTPSPSTPPTPSPP
X08044 ,IGHA1*02 (V)PSTPPTPSPP
X53707 ,IGHA2 (V)PPSPP
AF300449,IGHG1 (E)PKSCDTTHTCPPCA
AF300448,IGHG2 (E)PKCCVECPPCP
AF300447,IGHG3 [H1] (E)LKTPLGDTTHTCPQCP [H2] (E)PKSCDTSPPCPRCP
AF300436,IGHG4 (E)SKYGPPCPRCP
AF300445,IGHGP (E)PKTPCCDTTHTWPPCA
IMGT note:
| (1) | In the IGHA gene, the hinge (H) and CH2 are joined in a single exon. |
Created: 12/11/2002
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
|
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
|
|
|
|
Citing IMGT © Copyright 1995-2012 IMGT®, the international ImMunoGeneTics information system® |
|||
