The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
Macfas X53705 ,IGHA (A)SPTRPKVFPLSLEGTQ.....SDNVVVACLVQ GFFPQ.EPLN VTWSKSGAGV....TVINFPPSQDASG.....GLYTTSSQLTLPAAQC..PARESVTC HVEHY...TNPSQ DVAVPC
Macmul AY039245,IGHA (A)SPTKPKVFPLSLEGTQ.....SDNVVVACLVQ GFFPQ.KPLN VTWSKSGAGV....TVINFPPRQDASG.....GLYTTSSQLTLPAAQC..PASESVTC HVEHY...TNPRQ DVAVPCR
Macfas AF045536,IGHG1 c (A)STKGPSVFPLAPSSRSTS...ESTAALGCLVK DYFP..EPVT VSWNSGSLTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYVC NVNHKP..SNTKV DKRV
Macmul AF045537,IGHG1 c (A)STKGPSVFPLAPSSRSTS...ESTAALGCLVK DYFP..EPVT VSWNSGSLTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYVC NVNHKP..SNTKV DKRV
Macmul AF045539,IGHG2 c (A)STKGPSVFPLASCSRSTS...QSTGALGCLVK DYFP..EPVT VSWNSGALTS....GVHTFQAVLQSS......GLYSLSSVVTVPSSSL...GTQTYVC NVVHEP..SNTKV DKTV
Macmul AF045538,IGHG3 c (m) (A)STKGPS?FPLASCSRSTS...QSTAALGCLVK DYFP..EPVT VSWNSGALTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYVC NVVHEP..SNTKV DKRV
Macmul AF046784,IGHM c (m) (G)SASAPTLFPLVSCENAPLD..TNEVAVGCLAQ DFLP..DSIT FSWKFKNNSNISK.GVWGFPSVLRGG.......KYAATSQVLLASKDVMQGTDEHVVC KVQHP....NGNK EQNVPLP
CH2
Macfas X53705 ,IGHA CDKPRLSLRRPALEDLLL..GSEANLTCTLT GLRNP.SGAT FTWTPSSGKN....AVQQSPKRDPCG.......CYSVSSVLPGCAEPW..NNRVTFTC TAEHPE..LETQL TATISKP
Macmul AY039245,IGHA CDKPRLSLRRPALEDLLL..GSEANLTCTLT GLRDP.SGAT FTWTPSSGKN....AVQQSPEHDPCG.......CYSVSSVLPGCAEPW..NNRVTFTC TAEHPE..LETQL TATISKS
Macfas AF045536,IGHG1 c (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSQEDPDVK FNWYVNGAEVH...HAQTKPRETQYN......STYRVVSVLTVTHQDW..LNGKEYTC KVSNKA..LPAPI QKTISKDK
Macmul AF045537,IGHG1 c (S)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSQEDPDVK FNWYVNGAEVH...HAQTKPRETQYN......STYRVVSVLTVTHQDW..LNGKEYTC KVSNKA..LPAPI QKTISKDK
Macmul AF045539,IGHG2 c (P)AELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSQEEPDVK FNWYVDGVEVH...NAQTKPREEQFN......STYRVVSVLTVTHQDW..LNGKEYTC KVSNKA..LPAPK QKTVSKTK
Macmul AF045538,IGHG3 c (m) (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSQEDPEVQ FNWYVDGAEVH...HAQTKPREEQFN......STYRVVSVLTVTHQDW..LNGKEYTC KVSNKG..LPAPI EKTISKAK
Macmul AF046784,IGHM c (m) (V)LAERPPNVSVFVPPRDGFVGN.PRESKLICQAT GFSP..RQIE VSWLREGKQVGS..GITTDRVEAEAKES..GPTTFKVTSTLTVSERDW..LSQSVFTC RVDHR....GLTF QKNVSSVCGP
CH3
Macfas X53705 ,IGHA (G)NTFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..EDVL VRWLKGTEQLPRD.KYLTWESRKEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
Macmul AY039245,IGHA (G)NTFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..EDVL VRWLKGTEQLPRD.KYLTWESRKEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSV
Macfas AF045536,IGHG1 c (G)QPREPQVYTLPPSREELT...KNQVSLTCLVK GFYP..SDIV VEWESSGQPEN...TYKTTPPVLDSD......GSYFLYSKLTVDKSRW..RQGNVFSC SVMHEA.LHNHYT QKSLSLSP...GK
Macmul AF045537,IGHG1 c (G)QPREPQVYTLPPSREELT...KNQVSLTCLVK GFYP..SDIV VEWESSGQPEN...TYKTTPPVLDSD......GSYFLYSKLTVDKSRW..QQGNVFSC SVMHEA.LHNHYT QKSLSLSP...GK
Macmul AF045539,IGHG2 c (G)QPREPQVYTLPPPRKELT...KNQVSLTCLVK GFYP..SDIV VEWASNGQPEN...TYKTTPPVLDSD......GSYFLYSKLTVDKSRW..QQGNTFSC SVMHEA.LHNHYT QKSLSLSP...GK
Macmul AF045538,IGHG3 c (m) (G)QPREPQVYILPPPQEELT...KNQVSLTCLVT GFYP..SDIA VEWESNGQPEN...TYKTTPPVLDSD......GSYFLYSKLTVDKSRW..QQGNTFSC SVMHEA.LHNHYT QKSLSVSP
Macmul AF046784,IGHM c (m) (N)PDTAIRVFAIPPSFASIFL..TKSTKLTCLVT DLATY.DSVT ITWTRQNGEAL...KTHTNISESHPN......GTFSAVGEASICEDDW..NSGERFRC TVTHTD..LPSPL KQTISRPK
CH4
Macmul AF046784,IGHM c (m) (G)VAMHRPDVYLLPPAREQLNL..RESATITCLVT GFSP..ADIF VQWMQRGQPLSPE.KYVTSAPMPEPQA....PGRYFAHSILTVSEEDW..NTGETYTC VVAHEA.LPNRVT ERTVDKST
Hinge
Macarc AB017354,IGHA*01 (V)PPPKPCL
Macass AB013770,IGHA*01 (V)LPPNSCL
Macass AB013753,IGHA*02 (V)SQTKPCL
Macass AB013762,IGHA*03 (V)PPITPPCPS
Maccyc AB017366,IGHA*01 (V)PPITPPCPS
Maccyc AB017356,IGHA*02 (V)SQTKPCL
Macfas X53705 ,IGHA*01 (V)SETKPCL
Macfas AB013758,IGHA*02 (V)PPPNSCL
Macfas AB013764,IGHA*03 (V)PPITPPCPS
Macmul AY039245,IGHA*01 (V)PPPKCPSLK
Macmul AY039246,IGHA*02 (V)PPPNCRL
Macmul AY039247,IGHA*03 (V)PQPKPCL
Macmul AY039248,IGHA*04 (V)PPITPPCPS
Macmul AY039251,IGHA*07 (V)SQTKPCL
Macmul AB013768,IGHA*09 (V)PPPNSCL
Macmul AB013769,IGHA*10 (V)SETKPCL
Macmul AB013757,IGHA*12 (D)PQPKPCL
Macmul AB013761,IGHA*13 (G)IPPTPIPLPCPS
Macnem AB013765,IGHA*01 (V)PPITPPCPS
Macnem AB013771,IGHA*02 (V)SQTKPCL
Macsil AB013775,IGHA*01 (V)SQTKPCL
Macthi AB013752,IGHA*01 (V)PPPKPCL
Macfas AF045536,IGHG1 c (E)IKTCGGGSKPPTCPPCP
Macmul AF045537,IGHG1 c (E)IKTCGGGSKPPTCPPCT
Macmul AF045539,IGHG2 c (G)LPCRSTCPPC
Macmul AF045538,IGHG3 c (m) (E)FTPPCGDTTPPCPPCP
M1
Macmul AF045538,IGHG3 c (m) (E)LQLEESCVEAQDGSWTG
Macmul AF046784,IGHM c (m) (E)GEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLF
CONNECTING_REGION | TRANSMEMBRANE-REGION | CYTOPLASMIC-REGION
c: cDNA sequence
(m): transcript of a membrane chain
Macarc: Macaca arctoides (Stump-tailed macaque)
Macass: Macaca assamensis (Assam macaque)
Maccyc: Macaca cyclopis (Taiwan macaque)
Macfas: Macaca fascicularis (Crab-eating macaque)
Macmul: Macaca mulatta (Rhesus monkey)
Macnem: Macaca nemestrina (Pig-tailed macaque)
Macsil: Macaca silenus (Liontail macaque)
Macthi: Macaca thibetana (Pere David's macaque)
Created: 04/11/2002
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
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