The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
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A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
X53704 ,IGHA (A)SPTSPKVFPLNFCSIQP....DGNVVVACLVQ GFFPQ.EPLS VTWSESGQGV....TARNFPPSQDPTG.....GLYTTSSQLTLPATQC..QDGKSVTC HVKHY...TNPSQ DVTVPCR
M15399 ,IGHE (A)STQSPSIFPLTHCCKNIPSN.ATSVTLGCLVT GYFP..EPVM VTWDASSLHG....TTMTLPATTLTPS.....GHYATISLLTVSGAW....AKQMFTC RVAHTPSSADWVY NKTFG
AF300428,IGHG1 AVLQSS......GLYSLSSVVTVPSSSL...GTQTYIC NVDHKP..SNTKV DKKV
AF300426,IGHG2 AVLQSS......GLYSLSSVVTVPSSSL...GSQTYTC NVDHKP..SNTKV DKKV
AF300452,IGHG3 AVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVDHKP..SNTKV DKRV
CH2
X53704 ,IGHA (1) CGQPQLSLHRPALEDLLL..GSEANLTCTLT GLTNA.SGAT FTWTPSSGKN....AVQRPPERDLCG.......CYSVSSVLPGCADPW..NHGQTFTC TAEHPE..LKTQL TATLSKS
M15399 ,IGHE (V)CSRDFTPPTVKILQSSCDGGGHF.PLTIQLLCLVS GYTP..GTIN ITWLEDGQVMD...VDLSTASATQEG......ELASTQSELTLSQKRW..LSDRTYTC QVTYQ....GDTF EDSTKKCA
AF300428,IGHG1 (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTC
AF300426,IGHG2 (G)LTPPEGPSVFLFPPKPKDTLMI.SRTPEVTC
AF300452,IGHG3 (E)PELLGGPSVFLFPPKPKDTLMI.SGTPEVTC
CH3
X53704 ,IGHA (G)NTFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..KDVL VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTYAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
M15399 ,IGHE (D)SNPRGLSAYLSRPSPFDLFI..RKSPTPTCLVV DLAPSKGTVN LTWSRASGKPV...NHSTGKQEKQRN......GTLTVTSTLPVGTRDW..IEGETYQC RVTHPH..LPRAL VRSTTKTS
CH4
M15399 ,IGHE (G)PRAAPEVYAFATPEGPGS...RDKRTLACLIQ NFMP..EDIS VQWLHNEVQLPDA.RHSTTQPHKTKG......SSFFVFSRLEVTRAEW..EQKDEFIC RAVHEAASPSQTV QRTVSVNP...GK
Hinge
X53704 ,IGHA (V)PRPTPTPSTPPCPPPS
AF300428,IGHG1 (E)PKSCDTPRPCPPCP
AF300426,IGHG2 (E)LIIPCCDTPRLCPPCP
AF300452,IGHG3 [H1] (E)LKTPHDDTTHPCTPCP [H2] (E)PKSCDTPPPCPRCPRCP [H3] (E)PKSCDTPPTCPRCP
IMGT note:
| (1) | In the IGHA gene, the hinge (H) and CH2 are joined in a single exon. |
Created: 12/11/2002
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
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