Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRGV

In this table are listed representative rearranged complementary DNAs (cDNAs) and genomic DNAs (gDNAs).

Rearranged cDNAs (#c) and gDNAs (#g) TRGV sequences have been assigned to IMGT TRGV genes and alleles as described in Germline gene tables, Alignments of alleles and Tables of alleles. Assignments were performed using IMGT/V-QUEST.

TRGV
gene name
Reference sequences Rearranged cDNAs and gDNAs CDR lengths JUNCTION (5)
Allele name Accession
number
Clone name Accession numbers
2 TRGV2*01 M13429 HGP01 M27338 [4](1)#c [6.8.x]  
lambdaSP11 X57737/S72759 [14]#g [6.8.15] +
TRGV2*02 M27337 #c  HGT26 M27337 [4]#c [6.8.12] +
3 TRGV3*01 M13430 M13K Y00790 [11]#c [6.8.11] +
lambdaS12 M13824/X03437 [1]#g [6.8.11] +
HGP03 M27336 [4]#c [6.8.x] -
lambdaSP14 X57739/S72844 [14]#g [6.8.x]  
E103 S60175 [15](4)p5'#c [x.8.14] +
TRGV3*02 X04038   M13231 [3]#c [6.8.x] -
4 TRGV4*01 X15272 lambdaS13 M13584 [2]#g [6.8.x]  
5 TRGV5*01 X13355/M36286   Y00482 [5]#c [6.8.11] +
GH3 X15018/Y00814 [12]#g [6.8.10] +
8 TRGV8*01 M13434 pM17c64 X06774 [6]#c [6.8.12] +
PGamma1 M30894 [7]#c [6.8.10] +
9 TRGV9*01 X07205 HGP02 M27335 [4]#c [8.7.15] +
lambdaA6 X08086 [8]#g [8.7.x]  
IDP2.11 M16768 [9](3)#c [8.7.10] +
  X72500 [16]#c [8.7.11] +
  M16804 [9]p5'#c [8.7.10] +
TRGV9*02 X15274 lambdaK20 M13823/X03436 [13]#g [8.7.9] +
10 TRGV10*01 X07206 lambdaR12 X05503 [8]#g [8.8.x] -
9-4 S60779 [17]#c [8.8.16] +
HGP06 M27343 [4]p5'#c [x.x.13] +
HTG25 M27339 [4]p5'#c [x.x.x]  
HGP10 M27341 [4]p5'#c [x.x.x]  
HGP32 M27342 [4]p5'#c [x.x.14] +
TRGV10*02 X74798   X74774 [18]#c [8.8.11] +
HGP08 M27340 [4]p5'#c [x.x.x] -
11 TRGV11*01 Y11227 lambdaJM15 X07207 [10]#g [8.7.x] -
5A7 S60780 [17]#c [8.7.15] +
  X74775 [18](2)#c [8.7.x] -

p3': partial in 3', p5': partial in 5' (more than 10 amino acids missing in 5').
#: rearranged, #c: rearranged cDNA, #g: rearranged genomic DNA.

IMGT notes:
(1) HGP01 (M27338) has an undefined sequence from position AA74 to AA109 (IMGT numbering).
(2) No J-SEGMENT in this transcript. An unusual splicing involves a cryptic DONOR_SPLICE located within TRGV11 and the TRGC ACCEPTOR_SPLICE site ([18]).
(3) IDP2.11 (M16768) has 3 nucleotide mutations (a14>g, E5>G; a18>g; c22>g, Q8>E) compared to TRGV9*01 (X07205), which are probably reverse transcriptase errors ([9]).
(4) E103 (S60175) has 2 nucleotide mutations (t131>a, g132>c, H44>L) which correspond to point mutations introduced into the primer to create a PstI restriction enzyme site ([15]).
(5) + indicates in-frame JUNCTION, - indicates out-of-frame JUNCTION, a blank indicates not defined.

References:
[1] Lefranc, M.-P. et al., Nature, 319, 420-422 (1986).
[2] Lefranc, M.-P. et al., Cell, 45, 237-246 (1986).
[3] Dialynas, D.P. et al., Proc. Natl. Acad. Sci. USA, 83, 2619-2623 (1986).
[4] Yoshikai, Y. et al., Eur. J. Immunol., 17, 119-126 (1987).
[5] Bories, J.C. et al., Nucleic Acids Res., 15, 10059-10059 (1987).
[6] Tighe, L. et al., Eur. J. Immunol., 17, 1729-1736 (1987).
[7] Littman, D.R. et al., Nature, 326, 85-88 (1987).
[8] Forster, A. et al., EMBO J., 6, 1945-1950 (1987).
[9] Krangel, M.S. et al., Science, 237, 64-67 (1987).
[10] Huck, S., EMBO J., 7, 719-726 (1988).
[11] Hochstenbach, F. et al., J. Exp. Med., 168, 761-776 (1988).
[12] Okada, A. et al., J. Exp. Med., 168, 1481-1486 (1988).
[13] Bernard, F. et al., Nucleic Acids Res., 18, 6170-6170 (1990).
[14] Alexandre, D. et al., Int. Immunol., 3, 973-982 (1991).
[15] Mami-Chouaib, F. et al., J. Immunol., 147, 2864-2867 (1991).
[16] Davodeau, F. et al., J. Biol. Chem., 268, 15455-15460 (1993).
[17] Tsuruta, Y., et al., J. Immunol. Methods, 161, 7-21 (1993).
[18] Zhang, X.M. et al., Eur. J. Immunol., 24, 571-578 (1994).


Created: 17/01/2001
Authors: Géraldine Folch
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.


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