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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Positions in the sequence: limits from the first nucleotide of V-REGION to the last nucleotide.

genes find on cDNA and not assigned to germline are shown only in the pages Protein display and Alignments of alleles

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence (V-REGION) Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (V-REGION)
IGHV1 IGHV1-1 IGHV1-1*01 F DKEY-204F11 BX649502 [1] (9) 178789-179082
IGHV1-2 IGHV1-2*01 F DKEY-204F11 BX649502 [1] 184862-185156
IGHV1-3 IGHV1-3*01 F DKEY-204F11 BX649502 [1] 210031-210322
IGHV1-4 IGHV1-4*01 F DKEY-204F11 BX649502 [1] 216837-217125
IGHV1-5 IGHV1-5*01 F VHE1 AF273897 [2] (1)(9) 1-940
IGHV1-5*02 (F) + + VHcd5 AF273899 [2] (1,2) #c 1-259
IGHV2 IGHV2-1 IGHV2-1*01 F DKEY-204F11 BX649502 [1] 177065-177379
IGHV2-2 IGHV2-2*01 F DKEY-204F11 BX649502 [1] 183213-183510
IGHV2-3 IGHV2-3*01 F DKEY-204F11 BX649502 [1] 208008-208319
IGHV3 IGHV3-1 IGHV3-1*01 P DKEY-204F11 BX649502 [1] (3) 173255-175871
IGHV3-2 IGHV3-2*01 F DKEY-204F11 BX649502 [1] 187555-187849
IGHV3-3 IGHV3-3*01 P DKEY-204F11 BX649502 [1] (4) 202651-203934
IGHV4 IGHV4-1 IGHV4-1*01 F DKEY-204F11 BX649502 [1] 123044-123341
IGHV4-2 IGHV4-2*01 F DKEY-204F11 BX649502 [1] 125075-125369
IGHV4-3 IGHV4-3*01 F DKEY-204F11 BX649502 [1] 131285-131582
IGHV4-4 IGHV4-4*01 P DKEY-204F11 BX649502 [1] (5) 134074-136270
IGHV4-5 IGHV4-5*01 F DKEY-204F11 BX649502 [1] 141966-142266
IGHV4-6 IGHV4-6*01 F DKEY-204F11 BX649502 [1] 146039-146321
IGHV4-7 IGHV4-7*01 F DKEY-204F11 BX649502 [1] 148496-148796
IGHV4-8 IGHV4-8*01 F DKEY-204F11 BX649502 [1] 151534-151831
IGHV4-9 IGHV4-9*01 F DKEY-204F11 BX649502 [1] 153624-153918
IGHV5 IGHV5-1 IGHV5-1*01 F DKEY-204F11 BX649502 [1] 132442-132733
IGHV5-2 IGHV5-2*01 ORF DKEY-204F11 BX649502 [1] (6) 136851-137148
IGHV5-3 IGHV5-3*01 F DKEY-204F11 BX649502 [1] 140215-140520
IGHV5-4 IGHV5-4*01 ORF DKEY-204F11 BX649502 [1] (6) 143719-144019
IGHV5-5 IGHV5-5*01 ORF DKEY-204F11 BX649502 [1] (6) 149627-149927
IGHV5-6 IGHV5-6*01 P DKEY-204F11 BX649502 [1] (4) 152064-153112
IGHV5-7 IGHV5-7*01 F DKEY-204F11 BX649502 [1] 156629-156920
IGHV5-8 IGHV5-8*01 ORF DKEY-204F11 BX649502 [1] (6) 157912-158209
IGHV6 IGHV6-1 IGHV6-1*01 F DKEY-204F11 BX649502 [1] 138210-138507
IGHV6-2 IGHV6-2*01 ORF DKEY-204F11 BX649502 [1] (6) 162909-163206
IGHV7 IGHV7-1 IGHV7-1*01 F DKEY-204F11 BX649502 [1] 162116-162401
IGHV8 IGHV8-1 IGHV8-1*01 F DKEY-204F11 BX649502 [1] 164193-164490
IGHV8-2 IGHV8-2*01 F DKEY-204F11 BX649502 [1] 166467-166767
IGHV8-3 IGHV8-3*01 F DKEY-204F11 BX649502 [1] 168460-168757
IGHV8-4 IGHV8-4*01 F DKEY-204F11 BX649502 [1] 198852-199149
IGHV9 IGHV9-1 IGHV9-1*01 F DKEY-204F11 BX649502 [1] 169325-169613
IGHV9-2 IGHV9-2*01 F DKEY-204F11 BX649502 [1] 172378-172666
IGHV9-3 IGHV9-3*01 F DKEY-204F11 BX649502 [1] 199734-200026
IGHV9-4 IGHV9-4*01 F DKEY-204F11 BX649502 [1] 201864-202152
IGHV10 IGHV10-1 IGHV10-1*01 F DKEY-204F11 BX649502 [1] 171523-171820
IGHV10-2 IGHV10-2*01 P DKEY-204F11 BX649502 [1] (4) 200463-201506
IGHV11 IGHV11-1 IGHV11-1*01 F DKEY-204F11 BX649502 [1] 186083-186384
IGHV11-2 IGHV11-2*01 F DKEY-204F11 BX649502 [1] 204431-204731
IGHV12 IGHV12-1 IGHV12-1*01 P DKEY-204F11 BX649502 [1] (7) 190271-190574
IGHV12-2 IGHV12-2*01 P DKEY-204F11 BX649502 [1] (4) 213620-216158
IGHV13 IGHV13-1 IGHV13-1*01 P DKEY-204F11 BX649502 [1] (8) 190869-195154
IGHV13-2 IGHV13-2*01 F DKEY-204F11 BX649502 [1] 206907-207202
IGHV14 IGHV14-1 IGHV14-1*01 F DKEY-204F11 BX649502 [1] 211778-212073

#c: rearranged cDNA.

IMGT notes:
  1. (1) the gene IGHV1-5 was previously designated IGHV1S1
  2. (2) Not entered in IMGT/GENE-DB and IMGT/V-QUEST because cDNA and partial V-REGION: AA 1 to 4 are missing (partial FR1-IMGT) and FR3-IMGT partial in 3'.
  3. (3) Pseudogene because of putatives limites for FR3-IMGT and V-RS
  4. (4) Pseudogene because of frameshift in V-REGION, and no INIT-CODON in L-PART1
  5. (5) Pseudogene because of frameshift in V-REGION
  6. (6) ORF because AA 41 is a Phenylalanine (PHE) instead of the CONSERVED-TRP expected
  7. (7) Pseudogene because of STOP-CODON in V-REGION
  8. (8) Pseudogene because of putatives limites for FR3-IMGT, no 2nd-CYS and CDR3-IMGT and V-RS are not define
  9. (9) With 98.299% identity with IGHV1-1*01 (BX649502), it was suggested that the isolated IGHV1-5*01 sequence (AF273897) might represent an allele of IGHV1-1, however the localization in the locus being unknown the assignment remains uncertain and the IGHV1-5*01 name remains unmodified.
IMGT references:
  1. [1] Danilova N. et al., Nat. Immunol., 6, 295-302 (2005). PMID: 15685175
  2. [2] Danilova N. et al., Immunogenetics, 53, 82-5 (2000). PMID: 11132160
See also (IMGT Scientific chart):