Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name IMGT allele name Fct Serological
markers
Chromosomal
localization
T Pr IMGT/LIGM-DB locus reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F 21q24 Holstein CH1 KT723008 [1] 652007-652312 Brown Swiss (9) AF109167 [2] 68-373
H-CH2 (17) KT723008 [1] 652493-652822 Brown Swiss (9) AF109167 [2] 554-883
CH3 (including CHS) KT723008 [1] 653011-653402 Brown Swiss (9) AF109167 [2] 1072-1463
M KT723008 [1] 655709-655893
IGHD IGHD*01 P (1) 21q24 CH1 AF411244 [3] (19) 77-400
H1 AF411244 [3] (19) 540-629
H2 AF411245 [3] (19) 116-181
CH2 AF411245 [3] (19) 429-752
CH3 AF411245 [3] (19) 857-1177
M1 AF411246 [3] (19) 53-199
M2 AF411246 [3] (19) 416-421
IGHD*02 ORF (2) 21q24 Holstein CH1 KT723008 [1] 525572-525895
H1 KT723008 [1] 526036-526125
H2 KT723008 [1] 527527-527592
CH2 KT723008 [1] 527840-528163
CH3 KT723008 [1] 528268-528588
CHS KT723008 [1] 531422-531606
M1 KT723008 [1] 532785-532927
M2 KT723008 [1] 533143-533148
IGHDD1P IGHDD1P*01 P (3) 21q24 Holstein CH1 KT723008 [1] 336407-336730
H1 KT723008 [1] 336871-336960
H2 KT723008 [1] 338469-338534
CH2 KT723008 [1] 338782-339106
CH3 KT723008 [1] 339211-339531
CHS KT723008 [1] 342358-342542
M1 KT723008 [1] 343704-343846
M2 KT723008 [1] 344061-344066
IGHDD1P*02 P (4) 21q24 Hereford CH1 NW_001494075 (19) complement(24147-24470)
H1 NW_001494075 (19) complement(23917-24006)
H2 NW_001494075 (19) complement(22347-22408)
CH2 NW_001494075 (19) complement(21775-22099)
CH3 NW_001494075 (19) complement(21350-21670)
CHS NW_001494075 (19) complement(18339-18524)
M1 NW_001494075 (19) complement(17114-17256)
M2 NW_001494075 (19) complement(16894-16899)
IGHDD2P IGHDD2P*01 P (5) 21q24 Holstein CH1 KT723008 [1] 399736-399835
H1 KT723008 [1] 399976-400065
CH2 KT723008 [1] 400732-401055
CH3 KT723008 [1] 401160-401480
CHS KT723008 [1] 403717-403900
M1 KT723008 [1] 405056-405198
M2 KT723008 [1] 405414-405419
IGHDD3P IGHDD3P*01 P (5) 21q24 Holstein CH1 KT723008 [1] 453228-453327
H1 KT723008 [1] 453468-453557
CH2 KT723008 [1] 454224-454547
CH3 KT723008 [1] 454652-454972
CHS KT723008 [1] 457229-457412
M1 KT723008 [1] 458568-458710
M2 KT723008 [1] 458926-458931
IGHE IGHE*01 F 21q24 Brown Swiss (10) CH1 U63640 [4] (19) 264-548
CH2 U63640 [4] (19) 667-990
CH3 U63640 [4] (19) 1078-1398
CH4 (including CHS) U63640 [4] (19) 1471-1808
IGHE*02 F 21q24 Holstein CH1 KT723008 [1] 636798-637088
CH2 KT723008 [1] 637207-637530
CH3 KT723008 [1] 637618-637941
CH4 (including CHS) KT723008 [1] 638014-638351
M1 KT723008 [1] 640600-640733
M2 KT723008 [1] 640826-640918
IGHG1 IGHG1*01 F 21q24 8.10 CH1 X16701 [5] (19) 170-460 M25278
H X16701 [5] (19) 789-827 M25278
CH2 X16701 [5] (19) 954-1283 M25278
CH3 (including CHS) X16701 [5] (19) 1364-1689 M25278
IGHG1*02 (F) 21q24 mouse/bovine
heterohybridoma
(B/MT.4A.17.H5.A5)
CH1 X62916 [6] (19) c(s) 445-735
H X62916 [6] (19) c(s) 736-774
CH2 X62916 [6] (19) c(s) 775-1104
CH3 (including CHS) X62916 [6] (19) c(s) 1105-1431
IGHG1*03 (F) 21q24 Holstein-Friesian 2 (15) CH1 S82409 [7] (19) c(s) 1-294
H S82409 [7] (19) c(s) 295-330
CH2 S82409 [7] (19) c(s) 331-660
CH3 (including CHS) S82409 [7] (19) c(s) 661-987
IGHG1*04 F 21q24 Holstein CH1 KT723008 [1] 591535-591825
H KT723008 [1] 592157-592192
CH2 KT723008 [1] 592319-592648
CH3 (including CHS) KT723008 [1] 592731-593056
M1 KT723008 [1] 594605-594738
M2 KT723008 [1] 597452-597532
IGHG2 IGHG2*01 F (6) g2a (8) 21q24 2.26 CH1 M36946 [8] (19) 108-398 X06703
H M36946 [8] (19) 730-768 X06703
CH2 M36946 [8] (19) 906-1225 X06703
CH3 (including CHS) M36946 [8] (19) 1307-1632 X06703
IGHG2*02 F g2a (8) 21q24 32.2.8 (11) CH1 X16702 [5] (19) 122-415 M25279
H X16702 [5] (19) 744-782 M25279
CH2 X16702 [5] (19) 920-1240 M25279
CH3 (including CHS) X16702 [5] (19) 1320-1645 M25279
IGHG2*03 (F) g2a (8) 21q24 Holstein-Friesian 3 (16) CH1 S82407 [7] (19) c(s) 1-291
H S82407 [7] (19) c(s) 292-330
CH2 S82407 [7] (19) c(s) 331-651
CH3 (including CHS) S82407 [7] (19) c(s) 652-978
IGHG2*04 F 21q24 Holstein CH1 KT723008 [1] 614645-614935
H KT723008 [1] 615267-615305
CH2 KT723008 [1] 615443-615763
CH3 (including CHS) KT723008 [1] 615846-616171
M1 KT723008 [1] 617720-617853
M2 KT723008 [1] 618020-618100
IGHG3 IGHG3*01 F 21q24 Brown Swiss G3a (12,13) CH1 U63638 [9] (19) 122-414
H1 (18) U63638 [9] (19) 415-481
H2 U63638 [9] (19) 772-816
CH2 U63638 [9] (19) 946-1269
CH3 (including CHS) U63638 [9] (19) 1436-1761
IGHG3*02 F 21q24 Brown Swiss G3b (12,13) CH1 U63639 [9] (19) 166-458
H1 (18) U63639 [9] (19) 459-525
H2 U63639 [9] (19) 816-860
CH2 U63639 [9] (19) 990-1313
CH3 (including CHS) U63639 [9] (19) 1396-1721
IGHG3*03 F 21q24 Holstein CH1 KT723008 [1] 563429-563721
H1 (18) KT723008 [1] 563722-563788
H2 KT723008 [1] 564079-564123
CH2 KT723008 [1] 564253-564576
CH3 (including CHS) KT723008 [1] 564788-565113
M1 KT723008 [1] 566674-566807
M2 KT723008 [1] 566971-567051
IGHGP IGHGP*01 P (7) 21q24 psi-gamma CH1 M36947 [8] (19) 181-468
H M36947 [8] (19) 831-875
CH2 M36947 [8] (19) 1005-1328
CH3 (including CHS) M36947 [8] (19) 1412-1736
IGHM1 IGHM1*01 F 21q24 Brown Swiss (14) CH1 U63637 [10] (19) 262-585
CH2 U63637 [10] (19) 660-992
CH3 U63637 [10] (19) 1244-1558
CH4 (including CHS) U63637 [10] (19) 1691-2082
M1 U63637 [10] (19) 3994-4109
M2 U63637 [10] (19) 4203-4208
IGHM1*02 F 21q24 Holstein CH1 KT723008 [1] 326979-327302 P522 DQ497629 [11] 4463->4616
CH2 KT723008 [1] 327377-327709
CH3 KT723008 [1] 327962-328276
CH4 (including CHS) KT723008 [1] 328408-328799
M1 KT723008 [1] 330718-330833
M2 KT723008 [1] 330935-330940
IGHM1*03 F 21q24 Hereford CH1 NW_001494075 (19) complement(33544-33867)
CH2 NW_001494075 (19) complement(33137-33469)
CH3 NW_001494075 (19) complement(32571-32885)
CH4 (including CHS) NW_001494075 (19) complement(32048-32439)
M1 NW_001494075 (19) complement(30019-30134)
M2 NW_001494075 (19) complement(29912-29917)
IGHM1*04 F 21q24 P542 CH1 DQ497630 [11] (19) 4420->4572
IGHM2 IGHM2*01 F 21q24 CH1 AY230207 [12] (19) <1-308 AY158087 [3,12] 7819-8142
CH2 AY230207 [12] (19) 384-716 AY158087 [3,12] 8218->8259
CH3 AY230207 [12] (19) 968-1282
CH4 (including CHS) AY230207 [12] (19) 1414-1805
M1 AY230207 [12] (19) 3722->3799
IGHM2*02 F 21q24 Holstein CH1 KT723008 [1] 515831-516154
CH2 KT723008 [1] 516230-516562
CH3 KT723008 [1] 516814-517128
CH4 (including CHS) KT723008 [1] 517260-517651
M1 KT723008 [1] 519565-519680
M2 KT723008 [1] 519782-519787

c: cDNA sequence.
(s): transcript of a secreted chain.

IMGT notes:
  1. (1) frameshift in M1, noncanonical DONOR-SPLICE: ngc instead of ngt
  2. (2) noncanonical DONOR-SPLICE: ngc instead of ngt
  3. (3) frameshift in CH2, in frame STOP-CODON in CHS, noncanonical DONOR-SPLICE: ngc instead of ngt
  4. (4) frameshift in H2, in CH2 and in CHS, noncanonical DONOR-SPLICE: ngc instead of ngt
  5. (5) deletions in CH1, no H2, frameshift in CHS, noncanonical DONOR-SPLICE: ngc instead of ngt
  6. (6) This sequence was incorrectly designated a pseudogene by Symons et al., 1987 [8] because in their first sequence the nucleotide G at position 907/908 at the start of the CH2 was missing, leading to a frameshift. This sequence has been re-sequenced by Symons et al., 1989 [5] and the nucleotide has been resolved, permitting reclassification of the sequence as a functional gene
  7. (7) noncanonical DONOR-SPLICE: nct instead of ngt, in frame STOP-CODON and frameshift in CH3
  8. (8) The gamma chains are encoded, for their constant region, by the IGHG genes. g2a and g2b refer to polymorphic gamma 2 chains characterized serologically. The g2a and g2b chains were previously designated as IgG2a(A1) and IgG2a(A2) respectively, whereas the gamma 3 chain was designated as IgG2b/IgG3 [7]
  9. (9) Subcloned from phage 25 containing the bovine IGHA gene, provided by Katherine L. Knight [13]
  10. (10) Subcloned from phage clone 24 containing the bovine IGHE gene, provided by Katherine L. Knight [13]
  11. (11) Subcloned from phage clone 32.2 containing the bovine IGHG2 gene, provided by Katherine L. Knight [13]
  12. (12) Subcloned from phage clone 46.2 containing the bovine IGHG3 gene, provided by Katherine L. Knight [13]
  13. (13) The two alleles IGHG3*01 and IGHG3*02 differ from each other by a 6 amino acid substitution in the coding region and a 84 base pair (bp) insertion in the intron between the CH2 and CH3 exons of IGHG3*01 [8]. This insertion contains a 41 bp duplication
  14. (14) Subcloned from phage 15 containing the bovine IGHM gene, provided by Katherine L. Knight [13]
  15. (15) KABAT accession number: KADBID 027168
  16. (16) KABAT accession number: KADBID 027169
  17. (17) In the IGHA gene, the hinge and CH2 are joined in a single exon
  18. (18) Twenty-two additional amino acids are encoded by the 3' end of CH1. As this region is rich in proline (7 aa out of 22), it is likely to be part of the structural hinge [9]
  19. (19) Sequence not in locus
IMGT references:
  1. [1] Ma L. et al. J Immunol. 2016 May 15;196(10):4358-66. doi: 10.4049/jimmunol.1600158. Epub 2016 Apr 6. PMID: 27053761
  2. [2] Brown W.R. et al., Immunology, 91, 1-6 (1997). PMID: 9203958
  3. [3] Zhao Y. et al. J Immunol. 2002 Oct 15;169(8):4408-16. PMID: 12370374
  4. [4] Mousavi M. et al., Immunology, 92, 369-373 (1997). PMID: 9486110
  5. [5] Symons D.B. et al., Mol. Immunol., 26, 841-850 (1989). PMID: 2513487
  6. [6] Jackson T. et al., Mol. Immunol., 29, 667-676 (1992). PMID: 1584233
  7. [7] Kacskovics I. and Butler J.E., Mol. Immunol., 33, 189-195 (1996). PMID: 8649440
  8. [8] Symons D.B. et al., J. Immunogenet., 14, 273-283 (1987). PMID: 3141517
  9. [9] Rabbani H. et al., Immunogenetics, 46, 326-331 (1997). PMID: 9218535
  10. [10] Mousavi M. et al., Immunology, 93, 581-588 (1998). PMID: 9659232
  11. [11] Li M. et al. Unpublished.
  12. [12] Zhao Y. et al. J Biol Chem. 2003 Sep 12;278(37):35024-32. Epub 2003 Jun 26. PMID: 12829708
  13. [13] Knight K.L. et al., J. Immunol., 140, 3654-3659 (1988). PMID: 3361125
Acknowledgments:
See also (IMGT Scientific chart):