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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal
localization
R T Pr IMGT/LIGM-DB locus reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
IGHV1 IGHV1S2 IGHV1S2*01 P (1) Hereford BosTau_2_chr7 (21) complement(324605-325094)
IGHV1-7 IGHV1-7*01 F 21q24 Holstein KT723008 [1] 254411-254889
IGHV1-7*02 F 21q24 Hereford BosTau_1_chr21 (21) complement(179859-180337)
IGHV1-10 IGHV1-10*01 F 21q24 Holstein KT723008 [1] 240919-241389
IGHV1-10*02 F 21q24 U55170 [2] (21) 135->419 (22) U55171 [2] 135->419 (22)
IGHV1-14 IGHV1-14*01 F 21q24 Holstein KT723008 [1] 219315-219785
IGHV1-14*02 F 21q24 Hereford BosTau_1_chr21 (21) 90447-90917
IGHV1-14*03 F 21q24 U55175 [2] (21) 135->419 (22)
IGHV1-17 IGHV1-17*01 F 21q24 Holstein KT723008 [1] 205890-206360
IGHV1-20 IGHV1-20*01 F 21q24 Holstein KT723008 [1] 192395-192865
IGHV1-20*02 F 21q24 U55169 [2] (21) 135->419 (22)
IGHV1-21 IGHV1-21*01 F 21q24 Holstein KT723008 [1] 182166-182636 Hereford NW_014650055 (23) 1586-2056
IGHV1-21*02 F 21q24 U55172 [2] (21,24) 135->419 (22) U55173 [2] (24) 135->419 (22)
IGHV1-21*03 F 21q24 U55174 [2] (21,25) 135->419 (22)
IGHV1-25 IGHV1-25*01 F 21q24 Holstein KT723008 [1] 161913-162383
IGHV1-25*02 F 21q24 U55165 [2] (21,26) 135->419 (22)
IGHV1-27 IGHV1-27*01 F 21q24 Holstein KT723008 [1] 151031-151501 Hereford BosTau_1_chr21 113522-113992
IGHV1-30 IGHV1-30*01 F 21q24 Holstein KT723008 [1] 137522-137992 Hereford BosTau_2_chr7 complement(354908-355378)
IGHV1-30*02 F 21q24 Hereford NW_945934 (21) 103-574
IGHV1-30*03 F 21q24 U55168 [2] (21) 135->419 (22)
IGHV1-32 IGHV1-32*01 P (2) 21q24 Holstein KT723008 [1] 125433-125903
IGHV1-32*02 P (2) 21q24 Hereford BosTau_2_chr7 (21) complement(366995-367465)
IGHV1-33 IGHV1-33*01 F 21q24 Holstein KT723008 [1] 115170-115640 Hereford NW_014650055 (27) 1586-2056
IGHV1-33*02 F 21q24 U55172 [2] (21,28) 135->419 (22) U55173 [2] (28) 135->419 (22)
IGHV1-33*03 F 21q24 U55174 [2] (21,29) 135->419 (22)
IGHV1-37 IGHV1-37*01 F 21q24 Holstein KT723008 [1] 94916-95386 Hereford NW_938864 13083-13553
IGHV1-37*02 F 21q24 U55164 [2] (21) 135->419 (22)
IGHV1-37*03 F 21q24 U55165 [2] (21,30) 135->419 (22)
IGHV1-39 IGHV1-39*01 F 21q24 Holstein KT723008 [1] 84044-84514 Hereford BosTau_2_chr7 complement(337187-337657)
NW_938864 2175-2645
IGHV1-39*02 F 21q24 U55166 [2] (21) 135->419 (22)
IGHV1-39*03 F 21q24 U55167 [2] (21) 135->419 (22)
IGHV1-43 IGHV1-43*01 P (3) 21q24 Holstein KT723008 [1] 50677-51142
IGHV1-46 IGHV1-46*01 P (3) 21q24 Holstein KT723008 [1] 22560-23025
IGHV1-46*02 P (4) 21q24 Hereford BosTau_2_chr7 (21) 300834-301298
IGHV2 IGHV2S1 IGHV2S1*01 P (5) Hereford BosTau_2_chr7 (21) complement(322835-323310)
IGHV2-5 IGHV2-5*01 P (6) 21q24 Holstein KT723008 [1] 263079-263655
IGHV2-5*02 P (7) 21q24 Hereford BosTau_1_chr21 (21) complement(146803-147379)
IGHV2-6 IGHV2-6*01 P (8) 21q24 Holstein KT723008 [1] 256120-256661
IGHV2-6*02 P (8) 21q24 Hereford BosTau_1_chr21 (21) complement(178087-178628)
IGHV2-9 IGHV2-9*01 P (9) 21q24 Holstein KT723008 [1] 242690-243023 Hereford BosTau_1_chr21 115285-115618
IGHV2-12 IGHV2-12*01 P (10) 21q24 Holstein KT723008 [1] 228288-228734
IGHV2-12*02 P (11) 21q24 Hereford BosTau_1_chr21 (21) 99421-99862
IGHV2-13 IGHV2-13*01 P (12) 21q24 Holstein KT723008 [1] 221336-221849 Hereford BosTau_1_chr21 92468-92981
IGHV2-16 IGHV2-16*01 P (9) 21q24 Holstein KT723008 [1] 207656-207989
IGHV2-19 IGHV2-19*01 P (9) 21q24 Holstein KT723008 [1] 194162-194495
IGHV2-23 IGHV2-23*01 P (4) 21q24 Holstein KT723008 [1] 170312-170777 Hereford BosTau_2_chr7 (31) complement(219404-219869)
IGHV2-23*02 P (4) 21q24 Hereford BosTau_2_chr7 (21,32) 221983-222448
IGHV2-24 IGHV2-24*01 P (8) 21q24 Holstein KT723008 [1] 163675-164148
IGHV2-26 IGHV2-26*01 P (9) 21q24 Holstein KT723008 [1] 152794-153127
IGHV2-29 IGHV2-29*01 P (9) 21q24 Holstein KT723008 [1] 139294-139627 Hereford BosTau_2_chr7 complement(353271-353604)
NW_945934 1883-2216
IGHV2-31 IGHV2-31*01 P (13) 21q24 Holstein KT723008 [1] 127226-127697
IGHV2-31*02 P (13) 21q24 Hereford BosTau_2_chr7 (21) complement(365203-365674)
IGHV2-35 IGHV2-35*01 P (4) 21q24 Holstein KT723008 [1] 103314-103779 Hereford NW_938864 21148-21613
BosTau_2_chr7 (33) complement(219404-219869)
IGHV2-35*02 P (4) 21q24 Hereford BosTau_2_chr7 (21,34) 221983-222448
IGHV2-36 IGHV2-36*01 P (14) 21q24 Holstein KT723008 [1] 96563-97150 AF304438 [3] <1->180 (22)
Hereford NW_938864 14730-15318
IGHV2-38 IGHV2-38*01 P (15) 21q24 Holstein KT723008 [1] 85813-86152 Hereford BosTau_2_chr7 complement(335549-335888)
NW_938864 3944-4283
IGHV2-42 IGHV2-42*01 P (16) 21q24 Holstein KT723008 [1] 53913-54365 Hereford BosTau_2_chr7 (35) 304070-304522
IGHV2-45 IGHV2-45*01 P (16) 21q24 Holstein KT723008 [1] 25795-26247 Hereford BosTau_2_chr7 (36) 304070-304522
IGHV3 IGHV3-1 IGHV3-1*01 P (17) 21q24 Holstein KT723008 [1] 472057-472523
IGHV3-2 IGHV3-2*01 P (17) 21q24 Holstein KT723008 [1] 418464-418930
IGHV3-3 IGHV3-3*01 P (17) 21q24 Holstein KT723008 [1] 365146-365612
IGHV3-4 IGHV3-4*01 P (17) 21q24 Holstein KT723008 [1] 269274-269746
IGHV3-8 IGHV3-8*01 P (18) 21q24 Holstein KT723008 [1] 249238-249527 (22)
IGHV3-11 IGHV3-11*01 P (17) 21q24 Holstein KT723008 [1] 235527-235996 Hereford BosTau_1_chr21 <108461-108586 (22)
IGHV3-15 IGHV3-15*01 P (17) 21q24 Holstein KT723008 [1] 213951-214420 Hereford BosTau_1_chr21 85083-85552
IGHV3-18 IGHV3-18*01 P (18) 21q24 Holstein KT723008 [1] 200708-200996 (22)
IGHV3-22 IGHV3-22*01 P (17) 21q24 Holstein KT723008 [1] 176816-177285
IGHV3-28 IGHV3-28*01 P (18) 21q24 Holstein KT723008 [1] 145845-146134 (22) Hereford BosTau_1_chr21 106801-107090 (22)
IGHV3-34 IGHV3-34*01 P (17) 21q24 Holstein KT723008 [1] 109818-110287
IGHV3-40 IGHV3-40*01 P (19) 21q24 Holstein KT723008 [1] 78710-79177 Hereford BosTau_2_chr7 complement(342524-342991)
IGHV3-41 IGHV3-41*01 P (17) 21q24 Holstein KT723008 [1] 63800-64271
IGHV3-44 IGHV3-44*01 P (17) 21q24 Holstein KT723008 [1] 35681-36149 Hereford BosTau_2_chr7 285653-286121
complement(<225908-226137) (22)
IGHV3-44*02 P (17) 21q24 Hereford BosTau_1_chr21 (21) complement(140715-141184)
IGHV3-47 IGHV3-47*01 P (20) 21q24 Holstein KT723008 [1] 3043-3506 Hereford BosTau_2_chr7 complement(316624-317087)
IMGT notes:
  1. (1) frameshifts in L-PART2 and in V-REGION
  2. (2) in frame STOP-CODONs in V-REGION
  3. (3) 1st-CYS is replaced by Phe, frameshift in FR3-IMGT
  4. (4) frameshifts in V-REGION
  5. (5) no ACCEPTOR-SPLICE, 2nd-CYS is replaced by Leu
  6. (6) frameshifts in V-REGION, in frame STOP-CODON in FR2-IMGT
  7. (7) frameshifts in V-REGION, in frame STOP-CODON in FR2-IMGT, 2nd-CYS is replaced by in frame STOP-CODON
  8. (8) noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn, frameshift in CDR1-IMGT
  9. (9) frameshifts in L-PART1 and in L-PART2, deletions in V-REGION (aproximately 48 AA are missing)
  10. (10) frameshifts in L-PART2 and in V-REGION, noncanonical V-HEPTAMER: tacactg instead of cacagtg
  11. (11) frameshifts in L-PART2 and in V-REGION, noncanonical V-HEPTAMER: tacactg instead of cacagtg, unexpected V-SPACER length (22 nt instead of 23 nt), noncanonical V-NONAMER: gcaccagac instead of acaccagcc
  12. (12) noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn, frameshifts in V-REGION, in frame STOP-CODON in FR2-IMGT, noncanonical V-NONAMER: acacaggcc instead of acacaaacc
  13. (13) noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn, frameshifts in V-REGION, noncanonical V-NONAMER: acaccacac instead of acacaaacc
  14. (14) in frame STOP-CODON in L-PART1, noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn, frameshift in CDR1-IMGT
  15. (15) frameshift in L-PART2, deletions in V-REGION (aproximately 40 AA are missing)
  16. (16) noncanonical ACCEPTOR-SPLICE: ntgnn instead of nagnn, in frame STOP-CODON in FR1-IMGT, deletion in FR1-IMGT, frameshift in CDR1-IMGT
  17. (17) no INIT-CODON, frameshifts in V-REGION
  18. (18) no INIT-CODON, frameshifts in V-REGION, no V-NONAMER
  19. (19) no INIT-CODON, frameshifts in V-REGION, noncanonical V-NONAMER: tcagaccct instead of tcagaaacc
  20. (20) no INIT-CODON, frameshifts in L-PART2 and in V-REGION
  21. (21) Sequence not in locus
  22. (22) Positions in V-REGION
  23. (23) Can also be assigned to IGHV1-33*01
  24. (24) Can also be assigned to IGHV1-33*02
  25. (25) Can also be assigned to IGHV1-33*03
  26. (26) Can also be assigned to IGHV1-37*03
  27. (27) Can also be assigned to IGHV1-21*01
  28. (28) Can also be assigned to IGHV1-21*02
  29. (29) Can also be assigned to IGHV1-21*03
  30. (30) Can also be assigned to IGHV1-25*02
  31. (31) Can also be assigned to IGHV2-35*01
  32. (32) Can also be assigned to IGHV2-35*02
  33. (33) Can also be assigned to IGHV2-23*01
  34. (34) Can also be assigned to IGHV2-23*02
  35. (35) Can also be assigned to IGHV2-42*01
  36. (36) Can also be assigned to IGHV2-45*01
IMGT references:
  1. [1] Ma L. et al. J Immunol. 2016 May 15;196(10):4358-66. doi: 10.4049/jimmunol.1600158. Epub 2016 Apr 6. PMID: 27053761
  2. [2] Sinclair M.C. et al. J Immunol. 1997 Oct 15;159(8):3883-9. PMID: 9378976
  3. [3] Gautier M. et al. Unpublished.
See also (IMGT Scientific chart):