Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F 8 Boxer CH1 IMGT000001 [5] 1419857..1420162 Boxer AAEX03006125 [1] complement(108353..108658)
boxer H+CH2 (1) IMGT000001 [5] 1420410..1420751 Boxer AAEX03006125 [1] complement(107764..108105)
CH3 (including CHS) IMGT000001 [5] 1420953..1421338 Boxer AAEX03006125 [1] complement(107177..107562)
M IMGT000001 [5] 1423586..1423797 Boxer AAEX03006125 [1] complement(104718..104929)
IGHA*02 F CH1 L36871 [2] 188..493
H+CH2 (1) L36871 [2] 739..1077
CH3 (including CHS) L36871 [2] 1279..1664
M
IGHE IGHE*01 F boxer CH1 IMGT000001 [5] 1406272..1406568 Boxer AAEX03006125 [1] complement(121947..122243)
CH2 IMGT000001 [5] 1406765..1407088 Boxer AAEX03006125 [1] complement(121427..121750)
CH3 IMGT000001 [5] 1407181..1407501 Boxer AAEX03006125 [1] complement(121014..121334)
CH4 (including CHS) IMGT000001 [5] 1407576..1407913 Boxer AAEX03006125 [1] complement(120602..120939)
M1 IMGT000001 [5] 1409868..1409995 Boxer AAEX03006125 [1] complement(118520..118647)
M2 IMGT000001 [5] 1410090..1410170 Boxer AAEX03006125 [1] complement(118345..118425)
IGHE*02 F CH1 L36872 [2] 91..387
CH2 L36872 [2] 584..907
CH3 L36872 [2] 1000..1320
CH4 (including CHS) L36872 [2] 1395..1732
M1
M2
IGHG1 IGHG1*01 (F) IgG-A (2) CH1 AF354264 [3] c (s) 481..771
H AF354264 [3] c (s) 772..813
CH2 AF354264 [3] c (s) 814..1143
CH3 (including CHS) AF354264 [3] c (s) 1144..1473
M1
M2
IGHG2 IGHG2*01 F boxer CH1 IMGT000001 [5] 1360885..1361175 Boxer AAEX03006126 [1] complement(26664..26954)
H IMGT000001 [5] 1361465..1361521 Boxer AAEX03006126 [1] complement(26318..26374)
CH2 IMGT000001 [5] 1361648..1361977 Boxer AAEX03006126 [1] complement(25862..26191)
CH3 (including CHS) IMGT000001 [5] 1362084..1362409 Boxer AAEX03006126 [1] complement(25430..25755)
M1 IMGT000001 [5] 1363846..1363976 Boxer AAEX03006126 [1] complement(23863..23993)
M2 IMGT000001 [5] 1365672..1365752 Boxer AAEX03006126 [1] complement(22087..22167)
IGHG2*02 (F) IgG-B (2) CH1 AF354265 [3] c (s) 446..736
H AF354265 [3] c (s) 737..793
CH2 AF354265 [3] c (s) 794..1123
CH3 (including CHS) AF354265 [3] c (s) 1124..1450
M1
M2
IGHG3 IGHG3*01 (F) IgG-C (2) CH1 AF354266 [3] c (s) 455..745
H AF354266 [3] c (s) 746..796
CH2 AF354266 [3] c (s) 797..1126
CH3 (including CHS) AF354266 [3] c (s) 1127..1453
M1
M2
IGHG4 IGHG4*01 (F) IgG-D (2) CH1 AF354267 [3] c (s) 465..755
H AF354267 [3] c (s) 756..797
CH2 AF354267 [3] c (s) 798..1127
CH3 (including CHS) AF354267 [3] c (s) 1128..1457
M1
M2
IGHM IGHM*01 F boxer CH1 IMGT000001 [5] 1290316..1290633 Boxer AAEX03006126 [1] complement(97206..97523)
CH2 IMGT000001 [5] 1290713..1291051 Boxer AAEX03006126 [1] complement(96788..97126)
CH3 IMGT000001 [5] 1291309..1291626 Boxer AAEX03006126 [1] complement(96213..96530)
CH4 (including CHS) IMGT000001 [5] 1291730..1292121 Boxer AAEX03006126 [1] complement(95718..96109)
M1 IMGT000001 [5] 1294683..1294798 Boxer AAEX03006126 [1] complement(93041..93156)
M2 IMGT000001 [5] 1294903..1294908 Boxer AAEX03006126 [1] complement(92931..92936)

c: cDNA sequence.
(s): transcript of secreted chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
  2. (2) Canine IgG subclass biological characterization (modified from Table 8 [4]).

    Canine IgGIgG1IgG2IgG3IgG4
    Induction of cytolytic activity (ADCC)--/+++++++--
    Complement binding (human C1q)--/+++++--/+
    Fc gamma receptor I (FcγRI)+++++--/+
    Fc gamma receptor IIb (FcγRIIb)++++
    Fc gamma receptor III (FcγRIII)--+--/+--
    Fc neonatal receptor I (FcRn)++++--/+++
    Reactivity with protein A--/++++----
    Reactivity with protein G++++++++

    '+++' indicates very tight binding or high reactivity, '++' indicates good binding, '+' indicates that some binding was observed, '--/+' indicates little to no activation/binding, and '--' represents no binding. The table has been updated with the canine subclass names IgG1, IgG2, IgG3, IgG4, instead of A, B, C and D. For comparison with Structural and biological properties of human immunoglobulins, click here.

IMGT references:
  1. [1] Lindblad-Toh,K. et al., Nature, 438 (7069), 803-819 (2005). PMID: 16341006
  2. [2] Patel M. et al., Immunogenetics, 41, 282-286 (1995). PMID: 7721349
  3. [3] Tang L. et al., Vet. Immunol. Immunopathol., 80, 259-270 (2001). PMID: 11457479
  4. [4] Bergeron L.M. et al, Vet Immunol Immunopathol 157(1-2), 31-41 (2014). PMID: 24268690
  5. [5] Martin J. et al. Immunogenetics. 2017 Sep 19. doi: 10.1007/s00251-017-1028-0. PMID: 28924718
See also (IMGT Scientific chart):