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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct Chromosomal localization T Pr Allotypes Isoallotypes Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Clone names Accession numbers Positions in the sequence
IGHA1 IGHA1*01 F 14q32.33 cosmid Ig13; Ig-gamma3-122 CH1 J00220 [13] AF067420 [33] c
H+CH2 (1) J00220 [13]
CH3(including CHS) J00220 [13]
Hualphac (GMA5-alpha) M M60193 [21]
IGHA2 IGHA2*01 [14] F 14q32.33 A2m1 CH1 J00221 [13]
H+CH2 (1) J00221 [13]
CH3(including CHS) J00221 [13]
M
IGHA2*02 [14] F 14q32.33 A2m2,3 lambda-TOU-alpha-2 CH1 M60192 [21] R-731F5 AL928742 [41] (17)
H+CH2 (1) M60192 [21] (2) R-731F5 AL928742 [41] (17)
Tou II-5 H+CH2 (1) AJ012264 [13] (3) R-731F5 AL928742 [41] (17)
CH3(including CHS) AJ012264 [13] R-731F5 AL928742 [41] (17)
lambda-TOU-epsilon-alpha M M60194 [21] R-731F5 AL928742 [41] (17)
IGHA2*03 (17) F 14q32.33 A2m2 nA2m3 CH1 S71043 [26]
H+CH2 (1) S71043 [26]
CH3(including CHS) S71043 [26]
M
IGHD IGHD*01 F 14q32.33 CH1 K02875 [15]
H1 K02876 [15]
H2 K02877 [15]
CH2 K02878 [15]
CH3 K02879 [15]
CHS K02880 [15]
M1 K02881 [15]
M2 K02882 [15]
IGHD*02 F 14q32.33 CH1 X57331 [22]
H1 X57331 [22]
H2 X57331 [22]
CH2 X57331 [22]
CH3 X57331 [22]
CHS X57331 [22]
M1 X57331 [22]
M2 X57331 [22]
IGHE IGHE*01 F 14q32.33 CH1 J00222 [11]
CH2 J00222 [11]
CH3 J00222 [11]
CH4(including CHS) J00222 [11]
cosIg10 M1 X63693 [24]
M2 X63693 [24]
IGHE*02 F 14q32.33 CH1 L00022 [7]
CH2 L00022 [7]
CH3 L00022 [7]
CH4(including CHS) L00022 [7]
M1
M2
IGHE*03 F 14q32.33 CH1 [9] (19)
CH2 [9] (19)
CH3 [9] (19)
CH4(including CHS) [9] (19)
38A M1 M55420 [38]
M2 M55420 [38]
IGHE*04 F 14q32.33 R-731F5 CH1 AL928742
CH2 AL928742
CH3 AL928742
CH4(including CHS) AL928742
M1 AL928742
M2 AL928742
IGHEP1 IGHEP1*01 P (12) 14q32.33 cosmid Ig13; Ig-gamma3-122 CH3 J00223 [12] (9)
CH4(including CHS) J00223 [12]
M1
M2
IGHEP1*02 P (12) 14q32.33 CH3 X84668 [32]
CH4(including CHS)
M1
M2
IGHEP1*03 P (12) 14q32.33 CH3 X84669 [32]
CH4(including CHS)
M1
M2
IGHG1 IGHG1*01 F 14q32.33 G1m17,1 cosmid Ig13; Ig-gamma3-122 CH1 J00228 [5] (20,21)
H J00228 [5] (20,21)
CH2 J00228 [5] (20)
CH3(including CHS) J00228 [5] (20)
M1 X52847 [23] c
M2 X52847 [23] c
IGHG1*02 F 14q32.33 G1m17,1 CH1 Z17370 [25] (21)
H Z17370 [25] (21)
CH2 Z17370 [25]
CH3(including CHS) Z17370 [25]
M1
M2
IGHG1*03 (F) 14q32.33 G1m3 nG1m1 nG1m17 CH1 Y14737 [37] c (s)
H Y14737 [37] c (s)
CH2 Y14737 [37] c (s)
CH3(including CHS) Y14737 [37] c (s)
IGHG1*04 (F) 14q32.33 G1m17,1,27 CH1 JN582178 [41] c
H JN582178 [41] c
CH2 JN582178 [41] c
CH3(including CHS) JN582178 [41] c
IGHG2 IGHG2*01 F 14q32.33 G2m.. CH1 J00230 [6]
H J00230 [6] pIgG2-2, pIgG2-13, pIgG2-14 Z49802 [27] (22)
CH2 J00230 [6] pIgG2-2, pIgG2-13, pIgG2-14 Z49802 [27] (22)
CH3(including CHS) J00230 [6] pIgG2-2, pIgG2-13, pIgG2-14 Z49802 [27] (22)
M1 AB006775 [30] (4)
M2 AB006776 [30] (4)
IGHG2*02 F 14q32.33 G2m23 pIgG2n+1,pIgG2n+9,pIgG2n+12 CH1 AJ250170 [35]
H AJ250170 [35] pIgG2-1, pIgG2-3, pIgG2-4 Z49801 [27]
CH2 AJ250170 [35] pIgG2-1, pIgG2-3, pIgG2-4 Z49801 [27]
CH3(including CHS) AJ250170 [35] pIgG2-1, pIgG2-3, pIgG2-4 Z49801 [27]
M1
M2
IGHG2*03 F 14q32.33 G2m.. CH1 AF449616 [40]
H AF449616 [40]
CH2 AF449616 [40]
CH3(including CHS) AF449616 [40]
M1
M2
IGHG2*04 F 14q32.33 G2m.. CH1 AF449617 [40]
H AF449617 [40]
CH2 AF449617 [40]
CH3(including CHS) AF449617 [40]
M1
M2
IGHG2*05 F 14q32.33 G2m.. CH1 AF449618 [40]
H AF449618 [40]
CH2 AF449618 [40]
CH3(including CHS) AF449618 [40]
M1
M2
IGHG2*06 F 14q32.33 G2m.. R-731F5 CH1 AL928742
H AL928742
CH2 AL928742
CH3(including CHS) AL928742
M1 AL928742
M2 AL928742
IGHG3 (18) IGHG3*01 (15) F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 CH1 X03604 [17] X04646 [16] (5)
XN-6 D78345 [28]
AJ390235 [36]
H1 X03604 [17] pSgamma3h X04646 [16] (5)
XN-6 D78345 [28]
AJ390235 [36]
H2 X03604 [17] pSgamma3h X04646 [16] (5)
XN-6 D78345 [28]
AJ390235 [36]
H3 X03604 [17] pSgamma3h X04646 [16] (5)
XN-6 D78345 [28]
AJ390235 [36]
H4 X03604 [17] pSgamma3h X04646 [16] (5)
XN-6 D78345 [28]
AJ390235 [36]
CH2 X03604 [17] pSgamma3h X04646 [16] (5)
XN-6 D78345 [28]
AJ390235 [36]
CH3(including CHS) X03604 [17] D78345 [28]
XN-6 M1 D78345 [28]
M2 D78345 [28]
IGHG3*02 F 14q32.33 cosmid Ig13; Ig-gamma3-122 CH1 K01313 [10] (5)
H1 K01313 [10]
H2 K01313 [10]
H3 K01313 [10]
H4 K01313 [10]
CH2 K01313 [10] (5)
CH3(including CHS) K01314 [10] (13)
M1
M2
IGHG3*03 (16) F 14q32.33 G3m24* (G3m5,6,11,24,26) nG3m21 lambda gamma 3LAT CH1 X16110 [18] AJ390264 [36]
AJ390265 [36]
AJ390266 [36]
AJ390267 [36]
AJ390268 [36]
AJ390269 [36]
AJ390270 [36]
AJ390271 [36]
H1 X16110 [18] AJ390264 [36]
AJ390265 [36]
AJ390266 [36]
AJ390267 [36]
AJ390268 [36]
AJ390269 [36]
AJ390270 [36]
AJ390271 [36]
H3 X16110 [18] AJ390264 [36]
AJ390265 [36]
AJ390266 [36]
AJ390267 [36]
AJ390268 [36]
AJ390269 [36]
AJ390270 [36]
AJ390271 [36]
H4 X16110 [18] AJ390264 [36]
AJ390265 [36]
AJ390266 [36]
AJ390267 [36]
AJ390268 [36]
AJ390269 [36]
AJ390270 [36]
AJ390271 [36]
CH2 X16110 [18] AJ390264 [36]
AJ390265 [36]
AJ390266 [36]
AJ390267 [36]
AJ390268 [36]
AJ390269 [36]
AJ390270 [36]
AJ390271 [36]
CH3(including CHS) X16110 [18] AJ390264 [36]
AJ390265 [36]
AJ390266 [36]
AJ390267 [36]
AJ390268 [36]
AJ390269 [36]
AJ390270 [36]
AJ390271 [36]
lambda-gamma-3-LAT M1 M60195 [21]
M2 M60196 [21]
IGHG3*04 F 14q32.33 CH1 X99549 [29]
H1 X99549 [29]
H4 X99549 [29]
CH2 X99549 [29]
CH3(including CHS) X99549 [29]
M1
M2
IGHG3*05 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 (23) AJ390236 [36]
IGHG3*06 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 (23) AJ390237 [36]
IGHG3*07 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 (23) AJ390238 [36] AJ390239 [36]
AJ390240 [36]
IGHG3*08 F 14q32.33 (23) AJ390241 [36]
IGHG3*09 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 (23) AJ390242 [36] AJ390243 [36]
IGHG3*10 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 (23) AJ390246 [36]
IGHG3*11 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 (23) AJ390247 [36] AJ390248 [36]
AJ390249 [36]
AJ390250 [36]
AJ390251 [36]
X74165 [36] (8)
IGHG3*12 F 14q32.33 G3m5* (G3m5,10,11,13,14,26,27) nG3m21 CH1 AJ390252 [36] AJ390253 [36]
H1 AJ390252 [36] AJ390253 [36]
H2 AJ390252 [36] AJ390253 [36]
H4 AJ390252 [36] AJ390253 [36]
CH2 AJ390252 [36] AJ390253 [36]
CH3(including CHS) AJ390252 [36] AJ390253 [36]
M1
M2
IGHG3*13 F 14q32.33 G3m6* (G3m5,6,10,11,14,26,27) nG3m21 (23) AJ390244 [36] AJ390245 [36]
IGHG3*14 F 14q32.33 G3m21* (G3m21,26,27,28) nG3m11 (23) AJ390254 [36] AJ390255 [36]
AJ390256 [36]
AJ390257 [36]
AJ390258 [36]
X74166 [34] (8)
AJ390259 [36]
IGHG3*15 F 14q32.33 G3m21* (G3m21,26,27,28) nG3m11 (23) AJ390260 [36] AJ390261 [36]
IGHG3*16 F 14q32.33 G3m21* (G3m21,26,27,28) nG3m11 (23) AJ390262 [36] AJ390263 [36]
IGHG3*17 F 14q32.33 G3m15* (G3m10,11,13,15,27) nG3m5 nG3m21 (24) AJ390272 [36] AJ390273 [36]
AJ390274 [36]
AJ390275 [36]
IGHG3*18 F 14q32.33 G3m16* (G3m10,11,13,15,16,27) nG3m5 nG3m21 (24) AJ390276 [36] AJ390277 [36]
AJ390278 [36]
IGHG3*19 F 14q32.33 G3m16* (G3m10,11,13,15,16,27) nG3m5 nG3m21 (24) AJ390279 [36] AJ390280 [36]
AJ390281 [36]
AJ390282 [36]
AJ390283 [36]
AJ390284 [36]
IGHG4 IGHG4*01 F 14q32.33 nG4m(a) CH1 K01316 [2]
H K01316 [2]
CH2 K01316 [2]
CH3(including CHS) K01316 [2]
M1
M2
IGHG4*02 F 14q32.33 nG4m(b) CH1
H AJ001563 [31]
CH2 AJ001563 [31]
CH3(including CHS) AJ001563 [31]
M1
M2
IGHG4*03 F 14q32.33 nG4m(a) CH1
H
CH2 AJ001564 [31]
CH3(including CHS) AJ001564 [31]
M1
M2
IGHG4*04 F 14q32.33 nG4m(a) R-731F5 CH1 AL928742
H AL928742
CH2 AL928742
CH3(including CHS) AL928742
M1 AL928742
M2 AL928742
IGHGP IGHGP*01 ORF (11) 14q32.33 CH1 X06766 [19]
H X06766 [19]
CH2 X06766 [19]
CH3(including CHS) X06766 [19]
M1 X52849 [23]
M2 X52848 [23]
IGHM IGHM*01 F 14q32.33 CH1 X14940 [20]
CH2 X14940 [20]
CH3 X14940 [20]
CH4(including CHS) X14940 [20]
M1 X14939 [20]
M2 X14939 [20]
IGHM*02 F 14q32.33 CH1 K01307 [3] (6)
CH2 K01308 [3] (7)
K01309 [3] (8)
CH3 K01309 [3] (8) J00259 [1] (9)
V00561 [1] (9) J00259 [1] (9)
CH4(including CHS) J00260 [3] (10) V00562 [1] (14)
M1
M2
IGHM*03 F 14q32.33 CH1 X57331 [22]
CH2 X57331 [22]
CH3 X57331 [22]
CH4(including CHS) X57331 [22]
M1 X57331 [22]
M2 X57331 [22]

c: cDNA sequence.
(s): Transcript of a secreted chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and the CH2 are joined in a single exon.
  2. (2) Partial C-GENE: partial CH2 in 3'.
  3. (3) Partial C-GENE: partial CH2 in 5'.
  4. (4) Sequence assigned arbitrarily and temporarily to allele*01 in the absence of cDNA and complete genomic sequence.
  5. (5) Partial C-GENE: partial CH1 in 5' and partial CH2 in 3'.
  6. (6) Partial C-GENE: partial CH1 in 3'.
  7. (7) Partial C-GENE: partial CH2 in 3'.
  8. (8) Partial C-GENE: partial CH2 in 5' and partial CH3 in 3'.
  9. (9) Partial C-GENE: partial CH3 in 5'.
  10. (10) Partial C-GENE: partial CH4 in 5'.
  11. (11) DELETION of 3 bp in the CH3 which does not alter the open reading frame. The lack of SWITCH region seems to be the only defect responsible for the absence of protein.
  12. (12) DELETION of CH2 and CH3, DELETION of 3 bp in the ACCEPTOR-SPLICE of the CH3 leading to frameshifts.
  13. (13) Partial C-GENE: partial CH3 in 5' and 3'.
  14. (14) Partial C-GENE: partial CH4 in 5' and 3'.
  15. (15) Complete serological G3m typing: G3m(5,10,11,13,14,26,27) or G3m(b0,b1,b3,b4,b5,u,v); 5*=5,10,11,13,14 and b*=b0,b1,b3,b4,b5.
  16. (16) LAT IV-5 is homozygous for Gm(6,24*;1,17;..) and Gm(27,28) -or homozygous for Gm(b0,b1,c3,c5,u) and Gm(g5,v)- by study of this family [Lefranc G. et al., Hum. Genet., 50, 199-211 (1979)]; 6,24*=5,6,11,24,26.
    In the LAT IV-5 haplotype, the allotypes Gm27 and 28 have been shown to be be carried by the constant region of the IGHG1 gene. This Gm distribution has been found in other individuals with the same haplotype from African populations [Van Loghem, E. et al., Vox Sanguinis, 43, 301-309 (1982)].
  17. (17) Although the serological typing has not be done, the sequence encodes the Ser 212 (TCC) which corresponds to the A2m(2) allotype[14]. The EcoRI site which allows A2m(2) allotype determination by restriction fragment length polymorphism[14] is present.
  18. (18) The number of IGHG3 hinge exons is:
    • four exons in the most frequent alleles (IGHG3*01[17] and IGHG3*02[10])
    • three exons in allele IGHG3*03[18]
    • two exons in allele IGHG3*04[29]
  19. (19) Not submitted but comment in J00222.
  20. (20) J00228 corresponds to [5] (and not to [10], as indicated in the J00228 flat files. The correction has been asked to EMBL in December 1999).
  21. (21) Note that Ala 126 (225) (GCA) in Kabat Entry number 013486 is probably a typing error. The corresponding codon in the IMGT IGHG1 allele alignment is Val 98 (GTT), which is the last codon of the CH1 exon (and not the first codon of the hinge as shown in Kabat 013486). The IGHG1 Chimpanzee CH1 3' end is therefore identical to the human one, and Figure 3 and Discussion in Ehrlich P.H. et al., Molecular Immunology, 28, 319-322 (1991) should be revised accordingly. Comments added by M.-P. Lefranc on the 16/12/1999, following a question asked by M. Cerutti (France).
  22. (22) Z49802 previously described as a IGHG2*03 allele due to a289>g, g291>a, T97>A in CH3 is now considered as a IGHG2*01 allele, following the EMBL update of 20 september 1999 (a289, g291, T97).
  23. (23) The IGHG3 exon genomic organization of this allele is similar to that of the IGHG3*01 allele. The sequence encompasses CH1, H1, H2, H3 H4, CH2 and CH3 exons. The M1 and M2 exons were not sequenced.
  24. (24) The IGHG3 exon genomic organization of this allele is similar to that of the IGHG3*03 allele. The sequence encompasses CH1, H1, H3 H4, CH2 and CH3 exons. The M1 and M2 exons were not sequenced.
  25. (25) The CH2 Met 45.1 (ATG) has been shown to correlate with IGHG2 gene encoding the G2m(23) allotype [27]. In this paper the CH1 was not sequenced. More recently CH1 Thr 92 (ACC) has also shown to correlate with IGHG2 gene encoding the G2m(23) allotype [35].
  26. (26) Although the serological typing has not been done, the sequence encodes the CH2 Val 45.1 (GTG) which correlates with the absence of the G2m(23) [39].
IMGT references:
  1. [1] Takahashi N. et al., Nucleic Acids Res., 8, 5983-5991 (1980). PMID: 6450943
  2. [2] Ellison J. et al., DNA, 1, 11-18 (1981). PMID: 6299662
  3. [3] Rabbitts T.H. et al., Nucleic Acids Res., 9, 4509-4524 (1981). PMID: 6795593
  4. [4] Battey J. et al., Proc. Natl. Acad. Sci. USA., 79, 5956-5960 (1982). PMID: 6964396
  5. [5] Ellison J.W. et al., Nucleic Acids Res., 10, 4071-4079 (1982). PMID: 6287432
  6. [6] Ellison J.W. and Hood, L.E., Proc. Natl. Acad. Sci. U.S.A., 79, 1984-1988 (1982). PMID: 6804948
  7. [7] Flanagan G. and Rabbitts, T.H., EMBO J., 1, 655-660 (1982). PMID: 6234164
  8. [8] Krawinkel U. and Rabbitts, T.H., EMBO J., 1, 403-407 (1982). PMID: 6329676
  9. [9] Max E.E. et al., Cell, 29, 691-699 (1982). PMID: 6288268
  10. [10] Takahashi N. et al., Cell, 29, 671-679 (1982). PMID: 6811139
  11. [11] Ueda S.et al., EMBO J., 1, 1539-1544 (1982). PMID: 6327276
  12. [12] Hisajima H. et al., Proc. Natl. Acad. Sci. USA., 80, 2995-2999 (1983). PMID: 6407005
  13. [13] Flanagan J.G. et al., Cell, 36, 681-688 (1984). PMID: 6421489
  14. [14] Lefranc M.P. and Rabbitts, T.H., Nucleic Acids Res., 12, 1303-1311 (1984). PMID: 6322103
  15. [15] White M.B. et al., Science, 228, 733-737 (1985). PMID: 3922054
  16. [16] Huck S. et al., FEBS Lett., 208, 221-230 (1986). PMID: 2877902
  17. [17] Huck S. et al., Nucleic Acids Res., 14, 1779-1789 (1986). PMID: 3081877
  18. [18] Huck S. et al., Immunogenetics, 30, 250-257 (1989). PMID: 2571587
  19. [19] Bensmana M.et al., Nucleic Acids Res., 16, 3108-3108 (1988). PMID: 3130612
  20. [20] Dorai H. and Gillies, S.D., Nucleic Acids Res., 17, 6412-6412 (1989). PMID: 2505237
  21. [21] Bensmana M. and Lefranc, M.P., Immunogenetics, 32, 321-330 (1990). PMID: 1979064
  22. [22] Word C.J. et al., Int. Immunol., 1, 296-309 (1989). PMID: 2518659
  23. [23] Kinoshita K. et al., Immunol. Lett., 27, 151-156 (1991). PMID: 2026457
  24. [24] Zhang K. et al., J. Exp. Med., 176, 233-243 (1992). PMID: 1613458
  25. [25] Walls M.A. et al., Nucleic Acids Res., 21, 2921-2929 (1993). PMID: 8332501
  26. [26] Chintalacharuvu K. R. et al., J. Immunol., 152, 5299-5304 (1994). PMID: 8189047
  27. [27] Brusco A. et al., Immunogenetics, 42, 414-417 (1995). PMID: 7590976
  28. [28] Akahori Y. and Kurosawa, Y., Genomics, 41, 100-104 (1997). PMID: 9126488
  29. [29] Dard P. et al., Hum. Genet., 99, 138-141 (1997). PMID: 9003512
  30. [30] Tashita H. et al., J. Clin. Invest., 101, 677-681 (1998). PMID: 9449702
  31. [31] Brusco A. et al., Eur. J. Immunogenet., 25, 349-355 (1998). PMID: 9805657
  32. [32] Wiebe V., Lefranc, M.P., Lefranc, G., Unpublished.
  33. [33] Zheng S. et al., Unpublished.
  34. [34] Balbin M. et al., Immunogenetics, 39, 187-193 (1994). PMID: 8276465
  35. [35] Hougs L. et al., Immunogenetics, 52, 242-248 (2001). PMID: 11220626
  36. [36] Dard P. et al., Eur. J. Human Genet., 9, 765-772 (2001). PMID: 11781688
  37. [37] Paterson T. et al., Immunotechnology, 4, 37-47 (1998). PMID: 9661813
  38. [38] Sun L.K. et al., J. Immunol., 146, 199-205 (1991). PMID: 1701791
  39. [39] Brusco A. et al., Immunogenetics, 42, 414-417 (1995). PMID: 7590976
  40. [40] Hougs L. et al., Tissue Antigens, 61, 231-239 (2003). PMID: 12694572
  41. [41] Goetze, A.M, et al., Mol Immunol. Sep 23. (2011). PMID: 21945018
See also (IMGT Scientific chart):