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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Rearranged (R) and transcribed (T) information are from Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRGV.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence Secondary accession numbers Clone names Accession numbers Positions in the sequence
TRGV1 TRGV1 TRGV1*01 ORF (11) 7p14 - - - V1 MAP M12949 [1] V1S1P AF159056 [8] (12)
X15269 [6] (1,13) V1S1P AF159056 [8] (12)
TRGV2 TRGV2*01 F 7p14 + + + V2 MAP M13429 [1] V1S2 AF159056 [8] (12)
X15270 [6] (1,13) V1S2 AF159056 [8] (12)
TRGV2*02 (F) 7p14 + + + Vgamma1.9 M27337 [10] #c
TRGV3 TRGV3*01 F 7p14 + + + V3 MAP M13430 [1] V1S3 AF159056 [8] (12)
X15271 [6] (1,13) V1S3 AF159056 [8] (12)
TRGV3*02 F 7p14 + + + Vgamma1.1 MAP X04038 [2]
TRGV3P TRGV3P*01 (14) 7p14
TRGV4 TRGV4*01 F 7p14 + + + V4 MAP X15272 [6] V1S4 AF159056 [8] (12)
TRGV4*02 F 7p14 + + + V4 MAP X13354 [4] M36285 [4]
TRGV5 TRGV5*01 F 7p14 + + + V5 MAP X13355 [4] M36286 [4] V1S5 AF159056 [8] (12)
TRGV5P TRGV5P*01 P (2) 7p14 - - - V5P MAP M13431 [1]
TRGV5P*02 P (2) 7p14 V1S5P AF159056 [8] (12)
TRGV6 TRGV6*01 P (3) 7p14 - - - V6 MAP M13432 [1]
TRGV6*02 P (3) 7p14 V1S6P AF159056 [8] (12)
TRGV7 TRGV7*01 P (4) 7p14 + + - V7 MAP M13433 [1] V1S7P AF159056 [8] (12)
TRGV8 TRGV8*01 F 7p14 + + + V8 MAP M13434 [1] V1S8 AF159056 [8] (12)
X15273 [6] (1,13) V1S8 AF159056 [8] (12)
TRGV2 TRGV9 TRGV9*01 F 7p14 + + + V9*A1 MAP X07205 [3] V2 AF159056 [8]
TRGV9*02 F 7p14 + + + V9*A2 MAP X15274 [6]
TRGV3 TRGV10 TRGV10*01 ORF (5,6) 7p14 + + - V10*A1 MAP X07206 [3]
TRGV10*02 ORF (5,6) 7p14 + + - V10*A2 MAP X74798 [7] V3P AF159056 [8]
TRGV4 TRGV11 TRGV11*01 ORF (7,8) 7p14 + + - V11 MAP Y11227 [5]
TRGV11*02 ORF (7,8) 7p14 V4P AF159056 [8]
TRGVA TRGVA TRGVA*01 P (9) 7p14 - - - VA MAP X07208 [3] V5P AF159056 [8] (12)
TRGVB TRGVB TRGVB*01 P (10) 7p14 - - - VB MAP X07209 [3] V6P AF159056 [8]

#c: rearranged cDNA.
#g: rearranged genomic DNA.

IMGT notes:
  1. (1) These sequences overlap by 4 nucleotides including the INIT-CODON ATG.
  2. (2) STOP-CODON in the L-PART1.
  3. (3) DELETION of 1 bp at position 366-367 leading to a frameshift in FR3-IMGT.
  4. (4) DELETION of 1 bp at position 346-347 leading to a frameshift in FR3-IMGT.
  5. (5) Defective DONOR-SPLICE: NCT instead of NGT.
  6. (6) Absence of splicing of the V10 leader intron ([7,9])
  7. (7) Absence of splicing of the V11 leader intron ([7,9])
  8. (8) 1st-CYS replaced by a Trp in V-EXON.
  9. (9) STOP-CODON in frame in V-REGION.
  10. (10) STOP-CODONs and frameshift in V-REGION.
  11. (11) DELETION of 14 bp in the V-SPACER between the V-HEPTAMER and the V-NONAMER.
  12. (12) The sequence AF057177 (53151 bp) is included in AF159056 (nt 1-53151 of 140691 bp) and is not reported in this table to avoid redundancy. Both sequences start 5.8 kb upstream of TRGV1. AF057177 ends 1.6 kb downstream of TRGVA, whereas AF159056 encompasses the entire locus and ends 6.8 kb downstream of TRGC2 EX3.
  13. (13) 5'UTR of the gene.
  14. (14) Polymorphic gene by insertion identified by Southern hybridization [11].
IMGT references:
  1. [1] Lefranc M.-P. et al., Cell, 45, 237-246 (1986). PMID: 2938743
  2. [2] Quertermous T. et al., Nature, 322, 184-187 (1986). PMID: 3453106
  3. [3] Huck S. et al., EMBO J., 7, 719-726 (1988). PMID: 2969332
  4. [4] Font M.P. et al., J. Exp. Med., 168, 1383-1394 (1988). PMID: 2902186
  5. [5] Chen Z. et al., Blood, 72, 776-783 (1988). PMID: 2969758
  6. [6] Dariavach P. and Lefranc, M.-P., FEBS Lett., 256, 185-191 (1989). PMID: 2806544
  7. [7] Zhang X.M. et al., Eur. J. Immunol., 24, 571-578 (1994). PMID: 8125127
  8. [8] Zhan M. et al., Unpublished.
  9. [9] Zhang X.M. et al., Immunogenetics, 43, 196-203 (1996). PMID: 8575818
  10. [10] Yoshikai Y. et al., Eur.J.Immunol., 17, 119-126 (1987). PMID: 2949984
  11. [11] Ghanem et al., Hum. Genet., 86, 450-456 (1991). PMID: 1673112
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