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Homo sapiens interferon (IFN) genes

Homo sapiens interferon (IFN) genes and clusters

IFN cluster at 9p22

Gene name NC positions Orientation Gene definition and aliases Funct HGNC UniProt Gene ID mRNA and protein sequences MIM IMGT/3Dstructure-DB
IFNA1 NC_000009.12
21440454..21441316
FWD interferon alpha 1; IFN-alpha 1b, IFN, IFN-alpha, IFNA13, IFN-alphaD F 5417 P01562 (1) 3439 NM_024013.2 - NP_076918.1 147660 3ux9 (1)
IFNA2 NC_000009.12
21384255..21385397, complement
RP11-354P17.2
REV interferon alpha 2, IFNA, IFN-alphaA F 5423 P01563 3440 NM_000605.3 - NP_000596.2 147562 1itf, 1rh2, 2hie, 2hym, 2kz1, 2lag, 2lms, 3s9d, 3se3
IFNA4 NC_000009.12
21186618..21187599, complement
REV interferon, alpha 4, IFN-alpha4a, F 5425 P05014 3441 NM_021068.2 - NP_066546.1 147564
IFNA5 NC_000009.12
21304614..21305313, complement
RP11-380P16.5
REV interferon, alpha 5, IFN-alpha-5, IFN-alphaG F 5426 P01569 3442 NM_002169.2 - NP_002160.1 147565
IFNA6 NC_000009.12
21350318..21350887, complement
RP11-354P17.7
AL353732.14
REV interferon, alpha 6, IFN-alphaK F 5427 P05013 3443 NM_021002.2 - NP_066282.1 147566
IFNA7 NC_000009.12
21201469..21202205, complement
REV interferon, alpha 7, IFNA-J, IFN-alphaJ F 5428 P01567 3444 NM_021057.2 - NP_066401.2 147567
IFNA8 NC_000009.12
21409147..21410185
FWD interferon, alpha 8, IFN-alphaB F 5429 P32881 3445 NM_002170.3 - NP_002161.2 147568
IFNA10 NC_000009.12
21206181..21207143, complement
REV interferon, alpha 10, IFN-alphaC F 5418 P01566 3446 NM_002171.2 - NP_002162.1 147577
IFNA11P NC_000009.12
21398614..21399139, complement
REV interferon, alpha 10, IFN-alphaC P 5442 3461 -
IFNA12P NC_000009.12
21403246..21403555
FWD interferon, alpha 12, pseudogene, IFNP12 P 5443 158011 -
IFNA13 NC_000009.12
21367372..21368076, complement
REV interferon, alpha 13 F 5419 P01562 (1) 3447 NM_006900.3 - NP_008831.3 147578 3ux9 (1)
IFNA14 NC_000009.12
21239202..21239979, complement
REV interferon, alpha 14,LEIF2H, IFN-alphaH F 5420 P01570 3448 NM_002172.2 - NP_002163.2 147579
IFNA16 NC_000009.12
21216373..21217311, complement
REV interferon, alpha 16,IFN-alphaO F 5421 P05015 3449 NM_002173.2 - NP_002164.1 147580
IFNA17 NC_000009.12
21227243..21228222, complement
REV interferon, alpha 17, LEIF2C1, IFN-alphaI F 5422 P01571 3451 NM_021268.2 - NP_067091.1 147583
IFNA21 NC_000009.12
21165637..21166660, complement
REV interferon, alpha 21, IFN-alphaI F 5424 P01568 3452 NM_002175.2 - NP_002166.2 147584
IFNA22P NC_000009.12
21277688..21278563, complement
REV interferon, alpha 22, pseudogene, IFNAP22 P 5431 3453 -
INFB1 NC_000009.12
21077105..21077944, complement
RP11-113D19.1
REV interferon, beta 1, fibroblast,IFNB, IFB, IFF F 5434 3456 - 147640
IFNW1 NC_000009.12
21140632..21142145, complement
REV interferon, omega 1 F 5448 P05000 3467 NM_002177.1 - NP_002168.1 147553 3se4
IFNNP1 NC_000009.12
21058771..21059323, complement
REV interferon, nu 1, pseudogene P 32009 654783 -
IFNA20P NC_000009.12
21321300..21321827
FWD interferon, alpha 20, pseudogene, IFNP20 P 3463 -
IFNWP2 NC_000009.12
21420234..21420813
FWD interferon, omega 1 pseudogene 2 P 5452 646581 -
IFNWP4 NC_000009.12
interferon, omega 1 pseudogene 4 P 5453 3469 -
IFNWP5 NC_000009.12
21230821..21231853, complement
REV interferon, omega 1 pseudogene P 5454 392292 -
IFNWP9 NC_000009.12
21190146..21191244, complement
REV interferon, omega 1 pseudogene 9 P 5455 100130671 -
IFNWP15 NC_000009.12
21178510..21179598, complement
REV interferon, omega 1 pseudogene 15 P 5449 100130866 -
IFNWP18 NC_000009.12
21209192..21209899, complement
REV interferon, omega 1 pseudogene 18, pseudo-IFN-alpha-m P 5450 360001 -
IFNWP19 NC_000009.12
21455439..21456068
FWD interferon, omega 1 pseudogene 19 P 5451 3474 -
INFE NC_000009.12
21480839..21482313, complement
REV interferon, epsilon F 18163 338376 - 615223

IMGT note:

(1) IFNA1 and IFNA13 have an identical amino acid sequence. Todokoro K, Kioussis D, Weissmann C. Two non-allelic human interferon alpha genes with identical coding regions. EMBO J. 1984, 3(8):1809-12. PMID: 6479148

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IFNK gene on chromosome 9 at 9p21.2

Gene name NC positions Orientation Gene definition and aliases Funct HGNC UniProt Gene ID mRNA and protein sequences MIM IMGT/3Dstructure-DB
IFNK NC_000009.12
27524314..27526498 RP11-27J8.1
FWD interferon, kappa F 21714 Q9P0W0 56832 NM_020124.2 - NP_064509.2 615326

IFNG gene on chromosome 12 at 12q14

Gene name NC positions Orientation Gene definition and aliases Funct HGNC UniProt Gene ID mRNA and protein sequences MIM IMGT/3Dstructure-DB
IFNG 12q14 NC_000012.12
68154770..68159741, complement
REV interferon, gamma 5438 P01579 3458 NM_000619.2 - NP_000610.2 147570 1eku, 1fg9, 1fyh, 1hig, 3bes

IFNL cluster on chromosome 19 at 19q13.13

Gene name NC positions Orientation Gene definition and aliases Funct HGNC UniProt Gene ID mRNA and protein sequences MIM IMGT/3Dstructure-DB
IFNL1 19q13.13 NC_000019.10
39296325..39298672
FWD interferon, lambda 1, IL29 F 18363 Q8IU54 282618 NM_172140.1 - NP_742152.1 607403 3og4, 3og6
IFNL2 19q13.13 NC_000019.10
39268517..39270092
FWD interferon, lambda 2, IL28A 18364 Q8IZJ0 282616 NM_172138.1 - NP_742150.1 607401
IFNL3 19q13.13 NC_000019.10
39243632..39245077, complement
REV interferon, lambda 3, IL28B, IL28C 18365 Q8IZI9 282617 NM_172139.2 - NP_742151.2 607402 3hhc

Representation of the Homo sapiens interferon (IFN) genes and clusters on chromosomes

Arrows show genes with a reverse (REV) orientation on the chromosome (IMGT Index > Genomic orientation)

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Created:
04/02/2015
Editors:
Amélie Houles and Mélanie Arrivet
Contact:
Marie-Paule Lefranc