IMGT Repertoire (RPI)
Alignment of alleles: Human VPREB1
By homology with the IG and TR V-DOMAINs, the limits of the putative CDR3-IMGT are shown.
___________________________________________________________________________________________________________________________________
Accession Allele
number name
___________________________________________________________________________________________________________________________________
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Q P V L H Q P P A M S S A L G T T I R
M34927 , VPREB1*01 CAG CCG GTG CTA CAT CAG CCG CCG GCC ... ATG TCC TCG GCC CTT GGA ACC ACA ATC CGC
D86992 , VPREB1*02 --- --- --- --G --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---
D88270 , VPREB1*02 --- --- --- --G --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---
___________________CDR1-IMGT____________________
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
L T C T L R N D H D I G V Y S V Y
M34927 , VPREB1*01 CTC ACC TGC ACC CTG AGG AAC GAC CAT GAC ATC GGT GTG TAC AGC ... ... ... GTC TAC
D86992 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
D88270 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
_______________CDR2-
41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
W Y Q Q R P G H P P R F L L R Y F S Q S
M34927 , VPREB1*01 TGG TAC CAG CAG AGG CCG GGC CAC CCT CCC AGG TTC CTG CTG AGA TAT TTC TCA CAA TCA
D86992 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
D88270 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
IMGT________________
61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80
D K S Q G P Q V P P R F S G S K
M34927 , VPREB1*01 GAC AAG ... ... ... AGC CAG GGC CCC CAG GTC CCC ... CCT CGC TTC TCT GGA TCC AAA
D86992 , VPREB1*02 --- --- ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
D88270 , VPREB1*02 --- --- ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
D V A R N R G Y L S I S E L Q P E D E A
M34927 , VPREB1*01 GAT GTG GCC AGG AAC AGG GGG TAT TTG AGC ATC TCT GAG CTG CAG CCT GAG GAC GAG GCT
D86992 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
D88270 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
______________CDR3-IMGT________________________________
101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120
M Y Y C A M G A R S S E K E E R E R E W
M34927 , VPREB1*01 ATG TAT TAC TGT GCT ATG GGG GCC CGC AGC TCG GAG AAG GAG GAG AGG GAG AGG GAG TGG
D86992 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
D88270 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
121 122 123 124 125 126 127 128 129 130 131 132 133 134
E E E M E P T A A R T R V P *
M34927 , VPREB1*01 GAG GAA GAA ATG GAA CCC ACT GCA
D86992 , VPREB1*02 --- --- --- --- --- --- --- --- GCC AGG ACA CGT GTC CCT
D88270 , VPREB1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
- When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
- These polymorphic mutations are reported in Tables of alleles.
- Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence.
- Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
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Last updated: Wednesday, 03-Aug-2011 22:30:49 CEST
Author: Dominique Scaviner
Editor: Elodie Gemrot
Contact: Marie-Paule Lefranc
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References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
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Marie-Paule.Lefranc@igh.cnrs.fr.
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