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Other B7 Family entries

IMGT RPI entry from gene to protein for Homo sapiens B7H3

Citing IMGT RPI entry for B7H3

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

Number of alleles: 3

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
B7H3*01 F EX1-9 AJ583695 cDNA splicing A
B7H3*02 F EX1-9 AK075549 [1] cDNA (1) splicing A
B7H3*03 F EX1-8, 10 AK074849 [1] cDNA (2) splicing B

IMGT reference sequences (in FASTA format) for the allele(s): B7H3*01 to B7H3*03

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
B7H3*01 F EX1-3, EX6-9 AY358343 cDNA (3) splicing D
EX1-2, EX5-9 AF302102 cDNA (4) splicing E
NM_025240 cDNA splicing E
B7H3*02 F EX1-6 BC062581 cDNA (5) splicining C
EX1-9 NM_001024736 cDNA splicing A

Corresponding protein database accession numbers

Allele name Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
B7H3*01 AJ583695 Q5ZPR3 534 aa 1
NM_025240 NP_079516 316 aa 5
B7H3*02 AK075549 534 aa 1
NM_001024736 NP_001019907 534 aa 1
B7H3*03 AK074849 533 aa 2
IMGT notes:
  1. (1) In EX2 [D1] c81>t, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN and in EX3 [D2] c53>t, T18>M positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
  2. (2) Splicing B (533 aa). No EX9. In EX2 [D1] c81>t, in EX3 [D2] c53>t; T18>M and in EX6 t50>c; L7>P and t131>c.
  3. (3) Splcing C (493 aa). EX6 utilizes an alternative 5' DONOR-SPLICE site positioned 22 nt after the original splice site.
  4. (4) Splicing D (316 aa). No EX4, 5.
  5. (5) Splicing E (316 aa). No EX3, 4.
IMGT references:
  1. [1] Ota T. et al, DNA Research 12, 117-126 (2005). PMID: 16303743

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

B7H3*01: AJ583695(c)

Nucleotide sequence

1        atgctgcgtc ggcggggcag ccctggcatg ggtgtgcatg tgggtgcagc cctgggagca

61       ctgtggttct gcctcacagg agccctggag gtccaggtcc ctgaagaccc agtggtggca

121      ctggtgggca ccgatgccac cctgtgctgc tccttctccc ccgagcctgg cttcagcctg

181      gcacagctca acctcatctg gcagctgaca gataccaaac agctggtgca cagctttgct

241      gagggccagg accagggcag cgcctatgcc aaccgcacgg ccctcttccc ggacctgctg

301      gcacagggca acgcatccct gaggctgcag cgcgtgcgtg tggcggacga gggcagcttc

361      acctgcttcg tgagcatccg ggatttcggc agcgctgccg tcagcctgca ggtggccgct

421      ccctactcga agcccagcat gaccctggag cccaacaagg acctgcggcc aggggacacg

481      gtgaccatca cgtgctccag ctaccagggc taccctgagg ctgaggtgtt ctggcaggat

541      gggcagggtg tgcccctgac tggcaacgtg accacgtcgc agatggccaa cgagcagggc

601      ttgtttgatg tgcacagcat cctgcgggtg gtgctgggtg caaatggcac ctacagctgc

661      ctggtgcgca accccgtgct gcagcaggat gcgcacagct ctgtcaccat cacaccccag

721      agaagcccca caggagccgt ggaggtccag gtccctgagg acccggtggt ggccctagtg

781      ggcaccgatg ccaccctgcg ctgctccttc tcccccgagc ctggcttcag cctggcacag

841      ctcaacctca tctggcagct gacagacacc aaacagctgg tgcacagttt caccgaaggc

901      cgggaccagg gcagcgccta tgccaaccgc acggccctct tcccggacct gctggcacaa

961      ggcaatgcat ccctgaggct gcagcgcgtg cgtgtggcgg acgagggcag cttcacctgc

1021     ttcgtgagca tccgggattt cggcagcgct gccgtcagcc tgcaggtggc cgctccctac

1081     tcgaagccca gcatgaccct ggagcccaac aaggacctgc ggccagggga cacggtgacc

1141     atcacgtgct ccagctaccg gggctaccct gaggctgagg tgttctggca ggatgggcag

1201     ggtgtgcccc tgactggcaa cgtgaccacg tcgcagatgg ccaacgagca gggcttgttt

1261     gatgtgcaca gcgtcctgcg ggtggtgctg ggtgcgaatg gcacctacag ctgcctggtg

1321     cgcaaccccg tgctgcagca ggatgcgcac ggctctgtca ccatcacagg gcagcctatg

1381     acattccccc cagaggccct gtgggtgacc gtggggctgt ctgtctgtct cattgcactg

1441     ctggtggccc tggctttcgt gtgctggaga aagatcaaac agagctgtga ggaggagaat

1501     gcaggagctg aggaccagga tggggaggga gaaggctcca agacagccct gcagcctctg

1561     aaacactctg acagcaaaga agatgatgga caagaaatag cctga
Nucleotide sequence in FASTA format (without gaps) B7H3*01

Amino acid sequence

1        MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL

61       AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF

121      TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD

181      GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ

241      RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG

301      RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY

361      SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF

421      DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPEALWVT VGLSVCLIAL

481      LVALAFVCWR KIKQSCEEEN AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA*
Amino acid sequence in FASTA format (without gap) B7H3*01

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