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Other B7 Family entries

IMGT RPI entry from gene to protein for Homo sapiens B7H4

Citing IMGT RPI entry for B7H4

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

B7H4 Gene exon/intron organization

Legend:

Number of alleles: 2

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
B7H4*01 F EX1-5 AY346100 [1] cDNA
B7H4*02 F EX1-5 AL391476 gDNA (1)

IMGT reference sequences (in FASTA format) for the allele(s): B7H4*01 to B7H4*02

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
B7H4*01 F EX1-5 AK026071 cDNA
AY280972 cDNA
AY358352 cDNA
BC074729 cDNA
NM_024626 cDNA
EX1-2,4-5 DQ103757 cDNA splicing B (2)
EX1-3 AY442303 cDNA splicing C (3)

Corresponding protein database accession numbers

Allele name Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
B7H4*01 AY346100 Tr:Q7Z7D3 282 aa 1
NM_024626 NP_005182 282 aa 1
DQ103757 Tr:Q45VN0 166 aa 2
AY442303 Tr:Q5WPZ3 87 aa 3
B7H4*02 AL391476 282 aa 1
IMGT notes:
  1. (1) In EX3 [D1], a62>t; Q21>L, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
  2. (2) Splcing B (166 aa). No EX3.
  3. (3) Splcing C (87 aa). EX3 [D1] use an alternative splice site 88 nt upstream to the usual 5' ACCEPTOR-SPLICE site. This lead to premature termination.
IMGT references:
  1. [1] Zang X. and Allison J.P. Proc. Natl. Acad. Sci. U.S.A. 100, 10388-10392 (2003). PMID: 12920180

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

B7H4*01: AY346100(c) AL391476(g)

Nucleotide sequence

1        atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct

61       ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact

121      actgtcgcct cagctgggaa cattggggag gatggaatcc agagctgcac ttttgaacct

181      gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc

241      catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg

301      acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg

361      caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat

421      gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat

481      gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc

541      tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag

601      ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac

661      aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg

721      acagaatcgg agatcaaaag gcggagtcac ctacagctgc taaactcaaa ggcttctctg

781      tgtgtctctt ctttctttgc catcagctgg gcacttctgc ctctcagccc ttacctgatg

841      ctaaaataa
Nucleotide sequence in FASTA format (without gaps) B7H4*01

Amino acid sequence

1        MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE DGIQSCTFEP

61       DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR TAVFADQVIV GNASLRLKNV

121      QLTDAGTYKC YIITSKGKGN ANLEYKTGAF SMPEVNVDYN ASSETLRCEA PRWFPQPTVV

181      WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV

241      TESEIKRRSH LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK*
Amino acid sequence in FASTA format (without gap) B7H4*01

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