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Other CD2 Family entries

IMGT RPI entry from gene to protein for Homo sapiens CD2

Citing IMGT RPI entry for CD2

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD2 Gene exon/intron organization

Legend:

Number of alleles: 4

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD2*01 F EX1-5 X07871 [1] gDNA
CD2*02 F EX1-5 M16445 [2] cDNA (1)
CD2*03 F EX1-5 M16336 [3] cDNA (2)
CD2*04 F EX1-5 AK223393 cDNA (3)

IMGT reference sequences (in FASTA format) for the allele(s): CD2*01 to CD2*04

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD2*01 F EX1-5 M19806 gDNA
AL135798 gDNA
EX1-5 M14362 cDNA
CD2*02 F EX1-5 BC033583 cDNA
NM_001767 cDNA

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD2*01 X07871 P06729 351 aa 1
CD2*02 M16445 351 aa 1
NM_001767 NP_001758 351 aa 1
CD2*03 M16336 360 aa 1
CD2*04 AK223393 Tr:Q53F96 351 aa 1
IMGT notes:
  1. (1) In EX5 62c>a 21H>Q.
  2. (2) 360 aa. In EX5, c276 is absent. This deletion in the ORF leads to frame shift and the translation continues 27 nt beyond the 3' DONOR-SPLICE site until the first STOP-CODON, in frame, in the down stream intron.
  3. (3) In EX3 [D2] a117>g, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
IMGT references:
  1. [1] Lang G. et al, EMBO J. 7, 1675-1682 (1988). PMID: 2901953
  2. [2] Seed B. and Aruffo A. Proc. Natl. Acad. Sci. U.S.A. 84, 3365-3369 (1987) . PMID: 2437578
  3. [3] Sayre P.H. et al, Proc. Natl. Acad. Sci. U.S.A. 84, 2941-2945 (1987) . PMID: 2883656

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD2*01: X07871(g)

Nucleotide sequence

1        atgagctttc catgtaaatt tgtagccagc ttccttctga ttttcaatgt ttcttccaaa

61       ggtgcagtct ccaaagagat tacgaatgcc ttggaaacct ggggtgcctt gggtcaggac

121      atcaacttgg acattcctag ttttcaaatg agtgatgata ttgacgatat aaaatgggaa

181      aaaacttcag acaagaaaaa gattgcacaa ttcagaaaag agaaagagac tttcaaggaa

241      aaagatacat ataagctatt taaaaatgga actctgaaaa ttaagcatct gaagaccgat

301      gatcaggata tctacaaggt atcaatatat gatacaaaag gaaaaaatgt gttggaaaaa

361      atatttgatt tgaagattca agagagggtc tcaaaaccaa agatctcctg gacttgtatc

421      aacacaaccc tgacctgtga ggtaatgaat ggaactgacc ccgaattaaa cctgtatcaa

481      gatgggaaac atctaaaact ttctcagagg gtcatcacac acaagtggac caccagcctg

541      agtgcaaaat tcaagtgcac agcagggaac aaagtcagca aggaatccag tgtcgagcct

601      gtcagctgtc cagagaaagg tctggacatc tatctcatca ttggcatatg tggaggaggc

661      agcctcttga tggtctttgt ggcactgctc gttttctata tcaccaaaag gaaaaaacag

721      aggagtcgga gaaatgatga ggagctggag acaagagccc acagagtagc tactgaagaa

781      aggggccgga agccccacca aattccagct tcaacccctc agaatccagc aacttcccaa

841      catcctcctc caccacctgg tcatcgttcc caggcaccta gtcatcgtcc cccgcctcct

901      ggacaccgtg ttcagcacca gcctcagaag aggcctcctg ctccgtcggg cacacaagtt

961      caccagcaga aaggcccgcc cctccccaga cctcgagttc agccaaaacc tccccatggg

1021     gcagcagaaa actcattgtc cccttcctct aattaa
Nucleotide sequence in FASTA format (without gaps) CD2*01

Amino acid sequence

1        MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE

61       KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK

121      IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL

181      SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ

241      RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP

301      GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N*
Amino acid sequence in FASTA format (without gap) CD2*01

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