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IMGT RPI entry from gene to protein for Homo sapiens CD28

Citing IMGT RPI entry for CD28

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD28 Gene exon/intron organization

Legend:

Number of alleles: 1

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD28*01 F EX1-4 M37812-M37815[1] gDNA

IMGT reference sequences (in FASTA format) for the allele(s): CD28*01

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Clone names Exons Accession numbers Molecule type
CD28*01 F EX1-4 J02988 cDNA
EX1-4 (1) cDNA splicing B
EX1-4 AF222341[1] cDNA splicing C
EX1-4 AF222342(3) cDNA splicing D (2)
EX1-4 AF222343(4) cDNA splicing E
EX1-2,EX4 AJ295273(5) cDNA splicing F
CD28*01 F EX1-4 NM_006139 cDNA

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD28*01 M37812-M37815 P09693 220 aa 1
NM_006139 NP_006130 220 aa 1
IMGT notes:
  1. (1) IMGT spliced transcripts types (B to F) result from alternative splicing that affects EX2 and/or EX3. The resulting transcripts lack part or the totality of the extracellular V-LIKE-DOMAIN [D] and/or part of the totality of the TRANSMEMBRANE-REGION.
  2. (2) Transcript B (136 codons) lacks codons 40-124 replaced with a tyrosine (Y) codon. No accession number but described in PMID:2162892 and mentioned in M37812-M37815.
  3. (3) Transcript C (123 codons) lacks codons 40-137 replaced with a tryptophan (W) codon
  4. (4) Transcript D (101 codons) has no EX2
  5. (5) Transcript E (80 codons) lacks codons 40-124 replaced with a tyrosine (Y) codon and lacks codons 152-207
  6. (6) Transcript F is the smallest one (55 codons) it has a partial EX2 and EX4 no EX3 and lacks 40-124 codons replaced with a tyrosine (Y) codon.
IMGT references:
  1. [1] Lee, K.P. et al, Journal of Immunology 145, 344-352 (1990). PMID: 2162892
  2. [2] Hanawa, H. et al. Blood 99, 2138-2145 (2002). PMID: 11877290

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD28*01: M37812(g)

Nucleotide sequence

1        atgctcaggc tgctcttggc tctcaactta ttcccttcaa ttcaagtaac aggaaacaag

61       attttggtga agcagtcgcc catgcttgta gcgtacgaca atgcggtcaa ccttagctgc

121      aagtattcct acaatctctt ctcaagggag ttccgggcat cccttcacaa aggactggat

181      agtgctgtgg aagtctgtgt tgtatatggg aattactccc agcagcttca ggtttactca

241      aaaacggggt tcaactgtga tgggaaattg ggcaatgaat cagtgacatt ctacctccag

301      aatttgtatg ttaaccaaac agatatttac ttctgcaaaa ttgaagttat gtatcctcct

361      ccttacctag acaatgagaa gagcaatgga accattatcc atgtgaaagg gaaacacctt

421      tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt

481      ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg

541      agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg

601      cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc

661      tga
Nucleotide sequence in FASTA format (without gaps) CD28*01

Amino acid sequence

1        MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD

61       SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP

121      PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR

181      SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS *
Amino acid sequence in FASTA format (without gap) CD28*01

Legend: