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Other CD4 entries

IMGT RPI entry from gene to protein for Homo sapiens CD4

Citing IMGT RPI entry for CD4

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD4 Gene exon/intron organization

Legend:

Number of alleles: 5

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD4*01 F EX1-9 M12807 [1] cDNA
CD4*02 F EX1-9 M35160 [2] cDNA (1)
CD4*03 F EX4-5 U40625 [3] cDNA partial (2)
CD4*04 F EX1-9 DQ012936 gDNA (3)
CD4*05 F EX1-9 U47924 [4] gDNA (4)

IMGT reference sequences (in FASTA format) for the allele(s): CD4*01 to CD4*05

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD4*01 F EX1-2 S79267 cDNA partial
X87579 cDNA partial
CD4*04 F EX1-9 BC025782 cDNA
BT019791 cDNA
BT019811 cDNA
CD4*05 F EX1-9 NM_000616 cDNA

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD4*01 M12807 458 aa 1
CD4*02 M35160 458 aa 1
CD4*03 U40625 Tr:Q6LCP8 78 aa 1 partial
CD4*04 DQ012936 458 aa 1
CD4*05 U47924 P11942 458 aa 1
NM_000616 NP_000607 458 aa 1
IMGT notes:
  1. (1) In EX5 [D3] c199>t; R67>W numbering according to IMGT unique numbering for V-LIKE-DOMAIN. This mutation leads to OKT4-epitope deficiency.
  2. (2) Partial with only EX4 [D2]. c318>t.
  3. (3) In EX3 [D1] c261>t (c62>t), numbering according to IMGT unique numbering for V-LIKE-DOMAIN.
  4. (4) In EX3 [D1] c261>t (c62>t), and in EX5 [D3] c126>t numbering according to IMGT unique numbering for V-LIKE-DOMAIN and in EX8 c63>t.
IMGT references:
  1. [1] Maddon P.J, et al. Cell 42, 93-104 (1985). PMID: 2990730
  2. [2] Hodge,T.W., Sasso,D.R. and McDougal,J.S. Hum. Immunol. 30, 99-104 (1991). PMID: 1708753
  3. [3] Indraccolo. S, et al. Immunogenetics 44, 70-72 (1996). PMID: 8613144
  4. [4] Ansari-Lari.M.A, et al. Genome Res. 6, 314-326 (1996). PMID: 8723724

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD4*01: M12807(c) U47924(g)

Nucleotide sequence

1        atgaaccggg gagtcccttt taggcacttg cttctggtgc tgcaactggc gctcctccca

61       gcagccactc agggaaagaa agtggtgctg ggcaaaaaag gggatacagt ggaactgacc

121      tgtacagctt cccagaagaa gagcatacaa ttccactgga aaaactccaa ccagataaag

181      attctgggaa atcagggctc cttcttaact aaaggtccat ccaagctgaa tgatcgcgct

241      gactcaagaa gaagcctttg ggaccaagga aacttccccc tgatcatcaa gaatcttaag

301      atagaagact cagatactta catctgtgaa gtggaggacc agaaggagga ggtgcaattg

361      ctagtgttcg gattgactgc caactctgac acccacctgc ttcaggggca gagcctgacc

421      ctgaccttgg agagcccccc tggtagtagc ccctcagtgc aatgtaggag tccaaggggt

481      aaaaacatac agggggggaa gaccctctcc gtgtctcagc tggagctcca ggatagtggc

541      acctggacat gcactgtctt gcagaaccag aagaaggtgg agttcaaaat agacatcgtg

601      gtgctagctt tccagaaggc ctccagcata gtctataaga aagaggggga acaggtggag

661      ttctccttcc cactcgcctt tacagttgaa aagctgacgg gcagtggcga gctgtggtgg

721      caggcggaga gggcttcctc ctccaagtct tggatcacct ttgacctgaa gaacaaggaa

781      gtgtctgtaa aacgggttac ccaggaccct aagctccaga tgggcaagaa gctcccgctc

841      cacctcaccc tgccccaggc cttgcctcag tatgctggct ctggaaacct caccctggcc

901      cttgaagcga aaacaggaaa gttgcatcag gaagtgaacc tggtggtgat gagagccact

961      cagctccaga aaaatttgac ctgtgaggtg tggggaccca cctcccctaa gctgatgctg

1021     agcttgaaac tggagaacaa ggaggcaaag gtctcgaagc gggagaaggc ggtgtgggtg

1081     ctgaaccctg aggcggggat gtggcagtgt ctgctgagtg actcgggaca ggtcctgctg

1141     gaatccaaca tcaaggttct gcccacatgg tccaccccgg tgcagccaat ggccctgatt

1201     gtgctggggg gcgtcgccgg cctcctgctt ttcattgggc taggcatctt cttctgtgtc

1261     aggtgccggc accgaaggcg ccaagcagag cggatgtctc agatcaagag actcctcagt

1321     gagaagaaga cctgccagtg ccctcaccgg tttcagaaga catgtagccc catttga
Nucleotide sequence in FASTA format (without gaps) CD4*01

Amino acid sequence

1        MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK

61       ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL

121      LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG

181      TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW

241      QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA

301      LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV

361      LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI VLGGVAGLLL FIGLGIFFCV

421      RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI*
Amino acid sequence in FASTA format (without gap) CD4*01

Legend: