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Other CD2 Family entries

IMGT RPI entry from gene to protein for Homo sapiens CD48

Citing IMGT RPI entry for CD48

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD48 Gene exon/intron organization

Legend:

Number of alleles: 7

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD48*01 F EX1-4 M37766 [1] cDNA
CD48*02 F EX1-4 AL121985 gDNA (1)
CD48*03 F EX1-4 M59904 [2] cDNA (2)
CD48*04 F EX1-4 X06341[3] cDNA (3)
CD48*05 F EX1-4 BC016182 cDNA (4)
CD48*06 F EX1-4 CR457012 cDNA (5)
CD48*07 F EX1-4 BT019813 cDNA (6)

IMGT reference sequences (in FASTA format) for the allele(s): CD48*01 to CD48*07

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD48*02 F EX1-4 BC030224 cDNA splicing B (7)
CD48*05 F EX1-4 NM_001778 cDNA

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD48*01 M37766 P09326 243 aa 1
CD48*02 AL121985 243 aa 1
CD48*03 M59904 243 aa 1
CD48*04 X06341 243 aa 1
CD48*05 BC016182 243 aa 1
NM_001778 NP_001769 243 aa 1
CD48*06 CR457012 Tr:Q6IAZ2 243 aa 1
CD48*07 BT019813 Tr:Q5U055 243 aa 1
IMGT notes:
  1. (1) In EX2 [D1] a159>t; N53>I, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN
  2. (2) In EX1 c6>g; C2>W, EX2 [D1] a159>t; N53>I, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN and in EX3 [D2] g361>c, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN
  3. (3) In EX2 [D1] a159>t; N53>I, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN and in EX3 [D2] g361>c, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN
  4. (4) In EX2 [D1] a159>t; N53>I, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN and in EX3 [D2] c55>t; positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN
  5. (5) In EX2 [D1] a159>t; N53>I, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN and in EX3 [D2] t134.3>c, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN
  6. (6) In EX2 [D1] a159>t; N53>I and c262>t, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN
  7. (7) Splicing B. In EX2 [D1] a159>t; N53>I, positions according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN. No EX3-4. EX2 has no DONOR-SPLICE site and as a consequence the translation continues beyond the usual splice site until the first STOP-CODON, in frame, in the down stream intron.
IMGT references:
  1. [1] Korinek V. et al, Immunogenetics 33:108-112(1991). PMID: 1999350
  2. [2] Vaughan H.A. et al., Immunogenetics 33:113-117(1991) . PMID: 1999351
  3. [3] Staunton D.E. and Thorley-Lawson D.A., EMBO J. 6:3695-3701(1987). PMID: 2828034

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD48*01: AL121985(g) M37766(c)

Nucleotide sequence

1        atgtgctcca gaggttggga ttcgtgtctg gctctggaat tgctactgct gcctctgtca

61       ctcctggtga ccagcattca aggtcacttg gtacatatga ccgtggtctc cggcagcaac

121      gtgactctga acatctctga gagcctgcct gagaactaca aacaactaac ctggttttat

181      actttcgacc agaagaatgt agaatgggat tccagaaaat ctaagtactt tgaatccaaa

241      tttaaaggca gggtcagact tgatcctcag agtggcgcac tgtacatctc taaggtccag

301      aaagaggaca acagcaccta catcatgagg gtgttgaaaa agactgggaa tgagcaagaa

361      tggaagatca agctgcaagt gcttgaccct gtacccaagc ctgtcatcaa aattgagaag

421      atagaagaca tggatgacaa ctgttatctg aaactgtcat gtgtgatacc tggcgagtct

481      gtaaactaca cctggtatgg ggacaaaagg cccttcccaa aggagctcca gaacagtgtg

541      cttgaaacca cccttatgcc acataattac tccaggtgtt atacttgcca agtcagcaat

601      tctgtgagca gcaagaatgg cacggtctgc ctcagtccac cctgtaccct ggcccggtcc

661      tttggagtag aatggattgc aagttggcta gtggtcacgg tgcccaccat tcttggcctg

721      ttacttacct ga
Nucleotide sequence in FASTA format (without gaps) CD48*01

Amino acid sequence

1        MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP ENYKQLTWFY

61       TFDQKNVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ KEDNSTYIMR VLKKTGNEQE

121      WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL KLSCVIPGES VNYTWYGDKR PFPKELQNSV

181      LETTLMPHNY SRCYTCQVSN SVSSKNGTVC LSPPCTLARS FGVEWIASWL VVTVPTILGL

241      LLT*
Amino acid sequence in FASTA format (without gap) CD48*01

Legend: