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Other CD2 family entries

IMGT RPI entry from gene to protein for Homo sapiens CD58

Citing IMGT RPI entry for CD58

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD58 Gene exon/intron organization

Legend:

Number of alleles: 2

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD58*01 F EX1-6 Y14780-Y14785 [1] gDNA
CD58*02 F EX1-6 BC005930 [2] cDNA (1)

IMGT reference sequences (in FASTA format) for the allele(s): CD58*01 to CD58*02

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD58*01 F EX1-6 AL355794 gDNA
AL390066 gDNA
BT019816 cDNA
BT019817 cDNA
Y14780-Y14784 gDNA splicing B (2)
X06296 cDNA splcing B
CR456939 cDNA partial
EX2, EX4-6 D28586 cDNA partial

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD58*01 Y14180 P19256 250 aa 1
NM_001779 NP_001770 250 aa 1
CD58*02 BC005930 250 aa 1
IMGT notes:
  1. (1) In EX3 [D2] c84>t; H28>Y, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
  2. (2) Splicing B (237 aa). Utilizes an alternative ACCEPTOR-SPLICE site upstream to the usual splice site in EX5 and ends at the first STOP-CODON, in frame.
IMGT references:
  1. [1] Wallich .R. et al, J. Immunol. 160, 2862-2871 (1998) . PMID: 9510189
  2. [2] Seed .B. Nature 329, 840-842 (1987) . PMID: 3313052

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD58*01: Y14780(g) Y14781(g) Y14782(g) Y14783(g) Y14784(g) Y14785(g)

Nucleotide sequence

1        atggttgctg ggagcgacgc ggggcgggcc ctgggggtcc tcagcgtggt ctgcctgctg

61       cactgctttg gtttcatcag ctgtttttcc caacaaatat atggtgttgt gtatgggaat

121      gtaactttcc atgtaccaag caatgtgcct ttaaaagagg tcctatggaa aaaacaaaag

181      gataaagttg cagaactgga aaattctgaa ttcagagctt tctcatcttt taaaaatagg

241      gtttatttag acactgtgtc aggtagcctc actatctaca acttaacatc atcagatgaa

301      gatgagtatg aaatggaatc gccaaatatt actgatacca tgaagttctt tctttatgtg

361      cttgagtctc ttccatctcc cacactaact tgtgcattga ctaatggaag cattgaagtc

421      caatgcatga taccagagca ttacaacagc catcgaggac ttataatgta ctcatgggat

481      tgtcctatgg agcaatgtaa acgtaactca accagtatat attttaagat ggaaaatgat

541      cttccacaaa aaatacagtg tactcttagc aatccattat ttaatacaac atcatcaatc

601      attttgacaa cctgtatccc aagcagcggt cattcaagac acagatatgc acttataccc

661      ataccattag cagtaattac aacatgtatt gtgctgtata tgaatggtat tctgaaatgt

721      gacagaaaac cagacagaac caactccaat tga
Nucleotide sequence in FASTA format (without gaps) CD58*01

Amino acid sequence

1        MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP LKEVLWKKQK

61       DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE DEYEMESPNI TDTMKFFLYV

121      LESLPSPTLT CALTNGSIEV QCMIPEHYNS HRGLIMYSWD CPMEQCKRNS TSIYFKMEND

181      LPQKIQCTLS NPLFNTTSSI ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC

241      DRKPDRTNSN *
Amino acid sequence in FASTA format (without gap) CD58*01

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