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Other CD8A entries

IMGT RPI entry from gene to protein for Homo sapiens CD8A

Citing IMGT RPI entry for CD8A

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD8A Gene exon/intron organization

Legend:

Number of alleles: 4

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD8A*01 F EX1-6 M27161 [1] gDNA
CD8A*02 F EX1-2 M26313 [2] gDNA (1)
EX3-4 M26314 gDNA (1)
EX5-6 M26315 gDNA (1)
CD8A*03 (F) EX1-6 AY039664 [3] cDNA (2)
CD8A*04 (F) EX1-6 BC025715 cDNA (3)

IMGT reference sequences (in FASTA format) for the allele(s): CD8A*01 to CD8A*04

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD8A*01 F EX1-6 AC064848 gDNA
(F) M12824 cDNA
HomSap_1_chr2 cDNA splicing A
EX1-3, 5-6 HomSap_2_chr2 cDNA (4) splicing B
CD8A*02 (F) EX1-6 M12828 cDNA

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD8A*01 M27161 P01732 235 aa 1
NM_001768 NP_001759 235 aa 1
NM_171827 NP_001769 198 aa 2
CD8A*03 AY039664 235 aa 1
CD8A*04 BC025715 235 aa 1
IMGT notes:
  1. (1) In EX4 c51>t.
  2. (2) In EX2 [D] a298>c; G100>S, numbering according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN. This mutation prevents CD8 expression.
  3. (3) In EX2 [D] a302>g; Y101>C, numbering according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN and in EX4 51c>t.
  4. (4) No EX4 with 198 aa.
IMGT references:
  1. [1] Nakayama K. et al, Immunogenetics 30, 393-397 (1989). PMID: 2509342
  2. [2] Norment A.M. et al, The Journal of Immunology, 3312-3319 (1989). PMID: 2496167
  3. [3] De la Calle-Martin O. et al, The Journal of clinical investigation. 108, 117-123 (2001). PMID: 11435463

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD8A*01: M27161(g)

Nucleotide sequence

1        atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg

61       ccgagccagt tccgggtgtc gccgctggat cggacctgga acctgggcga gacagtggag

121      ctgaagtgcc aggtgctgct gtccaacccg acgtcgggct gctcgtggct cttccagccg

181      cgcggcgccg ccgccagtcc caccttcctc ctatacctct cccaaaacaa gcccaaggcg

241      gccgaggggc tggacaccca gcggttctcg ggcaagaggt tgggggacac cttcgtcctc

301      accctgagcg acttccgccg agagaacgag ggctactatt tctgctcggc cctgagcaac

361      tccatcatgt acttcagcca cttcgtgccg gtcttcctgc cagcgaagcc caccacgacg

421      ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc

481      ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc

541      tgtgatatct acatctgggc gcccctggcc gggacttgtg gggtccttct cctgtcactg

601      gttatcaccc tttactgcaa ccacaggaac cgaagacgtg tttgcaaatg tccccggcct

661      gtggtcaaat cgggagacaa gcccagcctt tcggcgagat acgtctaa
Nucleotide sequence in FASTA format (without gaps) CD8A*01

Amino acid sequence

1        MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP

61       RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GYYFCSALSN

121      SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA

181      CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV*
Amino acid sequence in FASTA format (without gap) CD8A*01

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