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IMGT RPI entry from gene to protein for Homo sapiens HFE

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

HFE Gene exon/intron organization

Legend:

Number of alleles: 2

IMGT reference alleles

Allele name Gene functionality IMGT reference sequences
Clone names Accession numbers Molecule type
HFE*01 F Z92910 gDNA
HFE*02 F gDNA [1]

IMGT reference sequences (in FASTA format) for the allele(s): HFE*01 to HFE*02

Other sequences from the literature

Allele name Gene functionality IMGT reference sequences
Clone names Accession numbers Molecule type
HFE*01 F U91328 gDNA
U60319 mRNA
AF079408 cDNA splicing B (1)
AF079407 cDNA splicing C (2)
AF079409 cDNA splicing D (3)
AJ249335 cDNA splicing E (4)
AJ250635 cDNA splicing F (5)
AF144242 cDNA splicing G (6)
AF149804 cDNA splicing H (7)

Corresponding protein database accession numbers

Allele name Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
HFE*01 U60319 NP_000401 348 aa
AF079408 NP_620576 250 aa (1)
AF079407 NP_620575 334 aa (2)
AF079409 NP_620577 236 aa (3)
AJ249335 NP_620578 325 aa (4)
AJ250635 NP_620579 168 aa (5)
AF144242 NP_620573 256 aa (6)
AF149804 NP_620572 242 aa (7)
HFE*02
IMGT notes:
  1. (1) Alternative splicing,missing exon 2.
  2. (2) Alternative splicing, missing part of exon 4.
  3. (3) Alternative splicing, missing exon 2 and part of exon 4.
  4. (4) Alternative splicing, missing part of exon 2.
  5. (5) Alternative splicing, missing exon 2 and exon 3.
  6. (6) Alternative splicing, missing exon 3.
  7. (7) Alternative splicing, missing exon 3 and part of exon 4.
IMGT references:
  1. [1] Ahouse, J. J. et al., J. Immun. 151, 6076-6088 (1993). PMID: 7504013

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

HFE*01: Z92910(g) U60319(c)

Nucleotide sequence

1        atgggcccgc gagccaggcc ggcgcttctc ctcctgatgc ttttgcagac cgcggtcctg

61       caggggcgct tgctgcgttc acactctctg cactacctct tcatgggtgc ctcagagcag

121      gaccttggtc tttccttgtt tgaagctttg ggctacgtgg atgaccagct gttcgtgttc

181      tatgatcatg agagtcgccg tgtggagccc cgaactccat gggtttccag tagaatttca

241      agccagatgt ggctgcagct gagtcagagt ctgaaagggt gggatcacat gttcactgtt

301      gacttctgga ctattatgga aaatcacaac cacagcaagg agtcccacac cctgcaggtc

361      atcctgggct gtgaaatgca agaagacaac agtaccgagg gctactggaa gtacgggtat

421      gatgggcagg accaccttga attctgccct gacacactgg attggagagc agcagaaccc

481      agggcctggc ccaccaagct ggagtgggaa aggcacaaga ttcgggccag gcagaacagg

541      gcctacctgg agagggactg ccctgcacag ctgcagcagt tgctggagct ggggagaggt

601      gttttggacc aacaagtgcc tcctttggtg aaggtgacac atcatgtgac ctcttcagtg

661      accactctac ggtgtcgggc cttgaactac tacccccaga acatcaccat gaagtggctg

721      aaggataagc agccaatgga tgccaaggag ttcgaaccta aagacgtatt gcccaatggg

781      gatgggacct accagggctg gataaccttg gctgtacccc ctggggaaga gcagagatat

841      acgtgccagg tggagcaccc aggcctggat cagcccctca ttgtgatctg ggagccctca

901      ccgtctggca ccctagtcat tggagtcatc agtggaattg ctgtttttgt cgtcatcttg

961      ttcattggaa ttttgttcat aatattaagg aagaggcagg gttcaagagg agccatgggg

1021     cactacgtct tagctgaacg tgagtga
Nucleotide sequence in FASTA format (without gaps) HFE*01

Amino acid sequence

1        MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF

61       YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV

121      ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR

181      AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL

241      KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS

301      PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE*
Amino acid sequence in FASTA format (without gap) HFE*01

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