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IMGT RPI entry from gene to protein for Homo sapiens ICOS

Citing IMGT RPI entry for ICOS

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

ICOS Gene exon/intron organization

Legend:

Number of alleles: 1

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
ICOS*01 F EX1-5 AF411058 [1] gDNA

IMGT reference sequences (in FASTA format) for the allele(s): ICOS*01

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Clones Exons Accession numbers Molecule type
ICOS*01 F BAC_22608 EX1-5 AF411059 gDNA
RP11-278L16 EX1-5 AC103880
EX1-5 AF488346
RP11-278L16 EX1-5 AF488347
EX1-5 AJ535718
EX1-5 AB023135 cDNA
MGC:40066 EX1-5 AJ277832
MGC:39850 EX1-5 BC028210
EX1-3 BC028006 cDNA(1) splicing B
EX1-5 NM_012092 cDNA

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
ICOS*01 AF411058 Q9Y6W8 199 aa 1
NM_012092 NP_036224 199 aa 1
IMGT notes:
  1. (1) No EX4-5. 168 aa.
IMGT references:
  1. [1] Ling,V., Wu,P.W. et al. Genomics 78, 155-168 (2001). PMID: 11735222
  2. [2] Strausberg,R.L. Proc. Natl. Acad. Sci. U.S.A. 99, 16899-16903 (2002). PMID: 12477932

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

ICOS*01: AF411058(g)

Nucleotide sequence

1        atgaagtcag gcctctggta tttctttctc ttctgcttgc gcattaaagt tttaacagga

61       gaaatcaatg gttctgccaa ttatgagatg tttatatttc acaacggagg tgtacaaatt

121      ttatgcaaat atcctgacat tgtccagcaa tttaaaatgc agttgctgaa aggggggcaa

181      atactctgcg atctcactaa gacaaaagga agtggaaaca cagtgtccat taagagtctg

241      aaattctgcc attctcagtt atccaacaac agtgtctctt tttttctata caacttggac

301      cattctcatg ccaactatta cttctgcaac ctatcaattt ttgatcctcc tccttttaaa

361      gtaactctta caggaggata tttgcatatt tatgaatcac aactttgttg ccagctgaag

421      ttctggttac ccataggatg tgcagccttt gttgtagtct gcattttggg atgcatactt

481      atttgttggc ttacaaaaaa gaagtattca tccagtgtgc acgaccctaa cggtgaatac

541      atgttcatga gagcagtgaa cacagccaaa aaatctagac tcacagatgt gaccctataa
Nucleotide sequence in FASTA format (without gaps) ICOS*01

Amino acid sequence

1        MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ

61       ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK

121      VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY

181      MFMRAVNTAK KSRLTDVTL*
Amino acid sequence in FASTA format (without gap) ICOS*01

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