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IMGT RPI entry from gene to protein for Homo sapiens KIR2DL2

Citing IMGT RPI entry for KIR2DL2

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

KIR2DL2 Gene exon/intron organization

Legend:

Number of alleles: 5

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
KIR2DL2*01 F EX1-8 U24075 [1] cDNA
KIR2DL2*02 F EX1-8 L76669 cDNA (1)
KIR2DL2*03 F EX1-8 AL133414 gDNA (2)
KIR2DL2*04 F EX1-8 AY366242 cDNA (3)
KIR2DL2*05 F EX2p, EX3-8 AF285433 cDNA (4)

IMGT reference sequences (in FASTA format) for the allele(s): KIR2DL2*01 to KIR2DL2*05

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
KIR2DL2*01 F EX1-8 NM_014219 cDNA
KIR2DL2*03 F EX2p, EX3-8 AF285434 cDNA (partial in 5')

Corresponding protein database accession numbers

Allele name Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
KIR2DL2*01 U24075 P43627 348aa 1
NM_014219 NP_055034 348aa 1
IMGT notes:
  1. (1) In EX7 t47>c; c50>g, S17>R; g51>c, E18>Q.
  2. (2) In EX4 [D2] t380>c, I127>T, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN. In EX8 g127>a, A43>T
  3. (3) In EX8 g127>a, A43>T.
  4. (4) No EX1 and partial EX2. Has 16 nt differences compared to allele*01.
IMGT references:
  1. [1] Wagtmann N. et al,Immunity 2 (5), 439-449 (1995). . PMID: 7749980

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

KIR2DL2*01: AL133414(g) U24075(c)

Nucleotide sequence

1        atgtcgctca tggtcgtcag catggcgtgt gttgggttct tcttgctgca gggggcctgg

61       ccacatgagg gagtccacag aaaaccttcc ctcctggccc acccaggtcg cctggtgaaa

121      tcagaagaga cagtcatcct gcaatgttgg tcagatgtca ggtttgagca cttccttctg

181      cacagagaag ggaagtttaa ggacactttg cacctcattg gagagcacca tgatggggtc

241      tccaaagcca acttctccat cggtcccatg atgcaagacc ttgcagggac ctacagatgc

301      tacggttctg ttactcactc cccctatcag ttgtcagctc ccagtgaccc tctggacatc

361      gtcatcacag gtctatatga gaaaccttct ctctcagccc agccgggccc cacggttctg

421      gcaggagaga gcgtgacctt gtcctgcagc tcccggagct cctatgacat gtaccatcta

481      tccagggagg gggaggccca tgaatgtagg ttctctgcag ggcccaaggt caacggaaca

541      ttccaggccg actttcctct gggccctgcc acccacggag gaacctacag atgcttcggc

601      tctttccgtg actctccata cgagtggtca aactcgagtg acccactgct tgtttctgtc

661      ataggaaacc cttcaaatag ttggccttca cccactgaac caagctctaa aaccggtaac

721      ccccgacacc tgcacattct gattgggacc tcagtggtca tcatcctctt catcctcctc

781      ttctttctcc ttcatcgctg gtgctccaac aaaaaaaatg ctgcggtaat ggaccaagag

841      tctgcaggga acagaacagc gaatagcgag gactctgatg aacaagaccc tcaggaggtg

901      acatacacac agttgaatca ctgcgttttc acacagagaa aaatcactcg cccttctcag

961      aggcccaaga cacccccaac agatatcatc gtgtacgcgg aacttccaaa tgctgagtcc

1021     agatccaaag ttgtctcctg cccatga
Nucleotide sequence in FASTA format (without gaps) KIR2DL2*01

Amino acid sequence

1        MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVRFEHFLL

61       HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI

121      VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHECR FSAGPKVNGT

181      FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN

241      PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV

301      TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP*
Amino acid sequence in FASTA format (without gap) KIR2DL2*01

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