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IMGT RPI entry from gene to protein for Homo sapiens MPZ

Citing IMGT RPI entry for MPZ

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

MPZ Gene exon/intron organization

Legend:

Number of alleles: 4

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
MPZ*01 F EX1-6 D14720 [1] gDNA
MPZ*02 F EX1-6 AL592295 gDNA (1)
MPZ*03 F EX1-6 L24893 [2] gDNA (2) splicing B
MPZ*04 F EX1-6 Z31718 [3] gDNA (3) splicing B

IMGT reference sequences (in FASTA format) for the allele(s): MPZ*01 to MPZ*04

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences Partiality
Exons Accession numbers Molecule type
MPZ*01 F EX1-3 S66705 cDNA (5) splicing B Partial
MPZ*02 F EX1-6 BC006491 cDNA
BT006165 cDNA
EX1-5 U10018 gDNA splicing B (4) Partial
EX1-6 NM_000530 cDNA
MPZ*03 F EX1-6 D10537 cDNA

Corresponding protein database accession numbers

Allele Name Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
MPZ*01 D14720 258 aa 1
MPZ*02 AL592295 Q5VTH4 258 aa 1
NM_000530 NP_000521 258 aa 1
MPZ*03 L24893 P25189 248 aa 2
MPZ*04 Z31718 Q14902 251 aa 2
IMGT notes:
  1. (1) V-LIKE-DOMAIN [D] is encoded by EX2 and EX3
  2. (2) In EX3 [D] 92a>g (257a>g) in V-LIKE-DOMAIN, numbering according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
  3. (3) Utilizes an alternate start codon 30 nt downstream. In EX2 [D] 149a>g (138.3a>g) and in EX3 [D] 84c>t (252t>c) and 132t>c (297c>t) in V-LIKE-DOMAIN, numbering according to IMGT unique numbering for V-LIKE-DOMAIN.
  4. (4) Utilizes an alternate start codon 30 nt downstream. In EX6 insertion of 2 nt at position 15 (15^16>ins^gc) which most probably arise by sequence error ot typing error. This insertion lead to the frame shift.
  5. (5) Partial. No EX1.
  6. (6) Splicing B. In EX2[D] at position 108 deletion of 3 nt (109-111ctc>del#); 37I>del#. This most probably result from sequencing error or typing error.
IMGT references:
  1. [1] Hayasaka K. et al., Biochem. Biophys.res. Commun.180, 515-518 (1991). PMID: 1719967
  2. [2] Pham Dinh D. et al., Hum. Mol. Genet.2, 2051-2054 (1993). PMID: 7509228
  3. [3] Rautenstrauss B. et al., Hum. Mol. Genet.3, 1701-1702 (1994). PMID: 7530550

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

MPZ*01: D14720(g)

Nucleotide sequence

1        atgctccggg cccctgcccc tgccccagct atggctcctg gggctccctc atccagcccc

61       agccctatcc tggctgtgct gctcttctct tctttggtgc tgtccccggc ccaggccatc

121      gtggtttaca ccgacaggga ggtccatggt gctgtgggct cccgggtgac cctgcactgc

181      tccttctggt ccagtgagtg ggtctcagat gacatctcct tcacctggcg ctaccagccc

241      gaaggaggca gagatgccat ttcgatcttc cactatgcca agggacaacc ctacattgac

301      gaggtgggga ccttcaaaga gcgcatccag tgggtagggg accctcgctg gaaggatggc

361      tccattgtca tacacaacct agactacagt gacaatggca cgttcacttg tgacgtcaaa

421      aaccctccag acatagtggg caagacctct caggtcacgc tgtatgtctt tgaaaaagtg

481      ccaactaggt acggggtcgt tctgggagct gtgatcgggg gtgtcctcgg ggtggtgctg

541      ttgctgctgc tgcttttcta cgtggttcgg tactgctggc tacgcaggca ggcggccctg

601      cagaggaggc tcagtgctat ggagaagggg aaattgcaca agccaggaaa ggacgcgtcg

661      aagcgcgggc ggcagacgcc agtgctgtat gcaatgctgg accacagcag aagcaccaaa

721      gctgtcagtg agaagaaggc caaggggctg ggggagtctc gcaaggataa gaaatag
Nucleotide sequence in FASTA format (without gaps) MPZ*01

Amino acid sequence

1        MLRAPAPAPA MAPGAPSSSP SPILAVLLFS SLVLSPAQAI VVYTDREVHG AVGSRVTLHC

61       SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ WVGDPRWKDG

121      SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV PTRYGVVLGA VIGGVLGVVL

181      LLLLLFYVVR YCWLRRQAAL QRRLSAMEKG KLHKPGKDAS KRGRQTPVLY AMLDHSRSTK

241      AVSEKKAKGL GESRKDKK*
Amino acid sequence in FASTA format (without gap) MPZ*01

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