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IMGT RPI entry from gene to protein for Homo sapiens VCAM1

Citing IMGT RPI entry for VCAM1

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

VCAM1 Gene exon/intron organization

Legend:

Number of alleles: 3

IMGT reference alleles

Allele name Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
VCAM1*01 F EX1-9 M73255 [1] gDNA
VCAM1*02 F EX1-9 AC093428 (3686..22990) gDNA (1)
VCAM1*03 F EX1-9 AK223266 cDNA (2)

IMGT reference sequences (in FASTA format) for the allele(s): VCAM1*01 to VCAM1*03

Other sequences from the literature

Allele name Gene functionality IMGT reference sequences Partiality
Exons Accession numbers Molecule type
VCAM1*01 F EX1-9 AF536818 gDNA
BC017276 cDNA
BC068490 cDNA
BC085003 cDNA
M60335 cDNA
EX1-4, EX6-9 M30257 [2] cDNA splicing B (3)
NM080682 cDNA splicing B partial
EX1-9 X53051 cDNA
EX1-3 AU121762 cDNA
EX1 M92431 gDNA
S50587 gDNA
EX9 CR749464 cDNA
EX1-9 NM001078 cDNA partial
VCAM1*02 F EX1-9 CR617596 cDNA
EX6-9 CR603251 cDNA

Corresponding protein database accession numbers

Allele Name Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
VCAM1*01 M73255 P19320 739 aa 1
CR749464 Q68DC4 53 aa 1
NM001078 NP001069 739 aa 1
NM080682 NP542413 647 aa 2
VCAM1*02 AC093428 (3686..22990) P19320 739 aa 1
VCAM1*03 AK223266 Q53FL7 739 aa 1
IMGT notes:
  1. (1) In EX9 149a>g.
  2. (2) In EX5 [D4] 45.2t>c; 15.1I>T, numbering according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
  3. (3) Splicing B. No EX5.
IMGT references:
  1. [1] Cybulsky M.I. et al., Proc. Natl. Acad. Sci. U.S.A. 88, 7859-7863 (1991). PMID: 1715583
  2. [2] Osborn L. et al., Cell 59, 1203-1211 (1989). PMID: 2688898

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

VCAM1*01: M73255(g)

Nucleotide sequence

1        atgcctggga agatggtcgt gatccttgga gcctcaaata tactttggat aatgtttgca

61       gcttctcaag cttttaaaat cgagaccacc ccagaatcta gatatcttgc tcagattggt

121      gactccgtct cattgacttg cagcaccaca ggctgtgagt ccccattttt ctcttggaga

181      acccagatag atagtccact gaatgggaag gtgacgaatg aggggaccac atctacgctg

241      acaatgaatc ctgttagttt tgggaacgaa cactcttacc tgtgcacagc aacttgtgaa

301      tctaggaaat tggaaaaagg aatccaggtg gagatctact cttttcctaa ggatccagag

361      attcatttga gtggccctct ggaggctggg aagccgatca cagtcaagtg ttcagttgct

421      gatgtatacc catttgacag gctggagata gacttactga aaggagatca tctcatgaag

481      agtcaggaat ttctggagga tgcagacagg aagtccctgg aaaccaagag tttggaagta

541      acctttactc ctgtcattga ggatattgga aaagttcttg tttgccgagc taaattacac

601      attgatgaaa tggattctgt gcccacagta aggcaggctg taaaagaatt gcaagtctac

661      atatcaccca agaatacagt tatttctgtg aatccatcca caaagctgca agaaggtggc

721      tctgtgacca tgacctgttc cagcgagggt ctaccagctc cagagatttt ctggagtaag

781      aaattagata atgggaatct acagcacctt tctggaaatg caactctcac cttaattgct

841      atgaggatgg aagattctgg aatttatgtg tgtgaaggag ttaatttgat tgggaaaaac

901      agaaaagagg tggaattaat tgttcaagag aaaccattta ctgttgagat ctcccctgga

961      ccccggattg ctgctcagat tggagactca gtcatgttga catgtagtgt catgggctgt

1021     gaatccccat ctttctcctg gagaacccag atagacagcc ctctgagcgg gaaggtgagg

1081     agtgagggga ccaattccac gctgaccctg agccctgtga gttttgagaa cgaacactct

1141     tatctgtgca cagtgacttg tggacataag aaactggaaa agggaatcca ggtggagctc

1201     tactcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa tgggagctct

1261     gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga gattgaatta

1321     cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga tatgaaatct

1381     ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac tggaaaagct

1441     cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa acaaaggcag

1501     agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt ggtcagccct

1561     tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca gggctttcct

1621     gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc tctttctgag

1681     aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta tttatgtgaa

1741     ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca agttactcca

1801     aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga cactgtcatc

1861     atctcttgta catgtggaaa tgttccagaa acatggataa tcctgaagaa aaaagcggag

1921     acaggagaca cagtactaaa atctatagat ggcgcctata ccatccgaaa ggcccagttg

1981     aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca attaagaagt

2041     ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc tgagcttctc

2101     gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat ttactttgca

2161     agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc aaaagtgtag
Nucleotide sequence in FASTA format (without gaps) VCAM1*01

Amino acid sequence

1        MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT GCESPFFSWR

61       TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE SRKLEKGIQV EIYSFPKDPE

121      IHLSGPLEAG KPITVKCSVA DVYPFDRLEI DLLKGDHLMK SQEFLEDADR KSLETKSLEV

181      TFTPVIEDIG KVLVCRAKLH IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG

241      SVTMTCSSEG LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN

301      RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ IDSPLSGKVR

361      SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL YSFPRDPEIE MSGGLVNGSS

421      VTVSCKVPSV YPLDRLEIEL LKGETILENI EFLEDTDMKS LENKSLEMTF IPTIEDTGKA

481      LVCQAKLHID DMEFEPKQRQ STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP

541      APKILWSRQL PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP

601      KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID GAYTIRKAQL

661      KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL VLYFASSLII PAIGMIIYFA

721      RKANMKGSYS LVEAQKSKV*
Amino acid sequence in FASTA format (without gap) VCAM1*01

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