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Other CD4 entries

IMGT RPI entry from gene to protein for Mus musculus CD4

Citing IMGT RPI entry for CD4

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CD4 Gene exon/intron organization

Legend:

Number of alleles: 2

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CD4*01 F EX1-2 M17076 [1] gDNA
EX3-4 M17077 gDNA
EX5 M17078 gDNA
EX6 M17079 gDNA
EX7-9 M17080 gDNA
CD4*02 F EX1-9 AC002397 gDNA (1)

IMGT reference sequences (in FASTA format) for the allele(s): CD4*01 to CD4*02

Other sequences from the literature

Allele names Gene functionality Strains IMGT reference sequences
Exons Accession numbers Molecule type
CD4*01 C57BL/cDJ EX5-6, 8 U75219 cDNA partial (2)splicing B
CD4*02 F EX1-9 AF045882 gDNA
NOD EX1-9 AK153966 cDNA
C57BL/6J EX1-9 AK161775
EX1-9 BC039137
EX1-9 M36850
EX1-9 X04836
EX1-9 M13816
EX1-9 NM_013488

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CD4*01 M17076 457 aa 1
M17077 457 aa 1
M17078 457 aa 1
M17079 457 aa 1
M17080 457 aa 1
CD4*02 AC002397 P06332 457 aa 1
NM_013488 NP_038516 457 aa 1
IMGT notes:
  1. (1) In EX2 [D1] a20>g; E7>G, numbering according to IMGT unique numbering for V-LIKE-DOMAIN.
  2. (2) Partial. Splicing B. No EX7. Skipping of EX7 cause the frame shift and the translation ends with in EX8.
IMGT references:
  1. [1] Gorman S.D, Tourvieille. B. and Parnes J.R. Proc. Natl. Acad. Sci. U.S.A. 84, 7644-7648 (1987). PMID: 2823269
  2. [2] Ansari-Lari. M.A. et al, Genome Res. 8, 29-40 (1998). PMID: 9445485

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD4*01: M17076(g) M17077(g) M17078(g) M17079(g) M17080(g)

Nucleotide sequence

1        atgtgccgag ccatctctct taggcgcttg ctgctgctgc tgctgcagct gtcacaactc

61       ctagctgtca ctcaagagaa gacgctggtg ctggggaagg aaggggaatc agcagaactg

121      ccctgcgaga gttcccagaa gaagatcaca gtcttcacct ggaagttctc tgaccagagg

181      aagattctgg ggcagcatgg caaaggtgta ttaattagag gaggttcgcc ttcgcagttt

241      gatcgttttg attccaaaaa aggggcatgg gagaaaggat cgtttcctct catcatcaat

301      aaacttaaga tggaagactc tcagacttat atctgtgagc tggagaacag gaaagaggag

361      gtggagttgt gggtgttcaa agtgaccttc agtccgggta ccagcctgtt gcaagggcag

421      agcctgaccc tgaccttgga tagcaactct aaggtctcta accccttgac agagtgcaaa

481      cacaaaaagg gtaaagttgt cagtggttcc aaagttctct ccatgtccaa cctaagggtt

541      caggacagcg acttctggaa ctgcaccgtg accctggacc agaaaaagaa ctggttcggc

601      atgacactct cagtgctggg ttttcagagc acagctatca cggcctataa gagtgaggga

661      gagtcagcgg agttctcctt cccactcaac tttgcagagg aaaacgggtg gggagagctg

721      atgtggaagg cagagaagga ttctttcttc cagccctgga tctccttctc cataaagaac

781      aaagaggtgt ccgtacaaaa gtccaccaaa gacctcaagc tccagctgaa ggaaacgctc

841      ccactcaccc tcaagatacc ccaggtctcg cttcagtttg ctggttctgg caacctgact

901      ctgactctgg acaaagggac actgcatcag gaagtgaacc tggtggtgat gaaagtggct

961      cagctcaaca atactttgac ctgtgaggtg atgggaccta cctctcccaa gatgagactg

1021     accctgaagc aggagaacca ggaggccagg gtctctgagg agcagaaagt agttcaagtg

1081     gtggcccctg agacagggct gtggcagtgt ctactgagtg aaggtgataa ggtcaagatg

1141     gactccagga tccaggtttt atccagaggg gtgaaccaga cagtgttcct ggcttgcgtg

1201     ctgggtggct ccttcggctt tctgggtttc cttgggctct gcatcctctg ctgtgtcagg

1261     tgccggcacc aacagcgcca ggcagcacga atgtctcaga tcaagaggct cctcagtgag

1321     aagaagacct gccagtgccc ccaccggatg cagaagagcc ataatctcat ctga
Nucleotide sequence in FASTA format (without gaps) CD4*01

Amino acid sequence

1        MCRAISLRRL LLLLLQLSQL LAVTQEKTLV LGKEGESAEL PCESSQKKIT VFTWKFSDQR

61       KILGQHGKGV LIRGGSPSQF DRFDSKKGAW EKGSFPLIIN KLKMEDSQTY ICELENRKEE

121      VELWVFKVTF SPGTSLLQGQ SLTLTLDSNS KVSNPLTECK HKKGKVVSGS KVLSMSNLRV

181      QDSDFWNCTV TLDQKKNWFG MTLSVLGFQS TAITAYKSEG ESAEFSFPLN FAEENGWGEL

241      MWKAEKDSFF QPWISFSIKN KEVSVQKSTK DLKLQLKETL PLTLKIPQVS LQFAGSGNLT

301      LTLDKGTLHQ EVNLVVMKVA QLNNTLTCEV MGPTSPKMRL TLKQENQEAR VSEEQKVVQV

361      VAPETGLWQC LLSEGDKVKM DSRIQVLSRG VNQTVFLACV LGGSFGFLGF LGLCILCCVR

421      CRHQQRQAAR MSQIKRLLSE KKTCQCPHRM QKSHNLI*
Amino acid sequence in FASTA format (without gap) CD4*01

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