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IMGT RPI entry from gene to protein for Mus musculus ICOS

Citing IMGT RPI entry for ICOS

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

ICOS Gene exon/intron organization

Legend:

Number of alleles: 2

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
ICOS*01 F EX1-5 AF327184-AF327185[1] gDNA
ICOS*02 F EX1-5 AF257230 cDNA

IMGT reference sequences (in FASTA format) for the allele(s): ICOS*01 to ICOS*02

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Clones Exons Accession numbers Molecule type
ICOS*01 F RP23-148E7 EX1-5 AL645744 gDNA
ICOS*01B F RP23-148E7 EX1-4 AL645744 gDNA (2) splicing B
ICOS*01 F MGC:41104 EX1-5 BC034852 cDNA
ICOS*02 F EX1-5 AJ250559 cDNA
EX1-5 AB023132
EX1-5 NM_017480

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
ICOS*01 AF327184-AF327185 Sw:Q9WVS0 200 aa 1
AL645744 Tr:Q5SUZ8(2) 223 aa 2
ICOS*02 AF257230 220 aa 1
NM_017480 NP_059508 220 aa 1
IMGT notes:
  1. (1) In the EX1(g20>a,R7>H).
  2. (2) In the flat file:AL645744, an alternative splicing is proposed with longer EX4(168nt, 55aa) and without EX5, but so far (20/09/05) no cDNA has been described. If confermed by experimental data, this can be refered as splicing B.
IMGT references:
  1. [1] Tezuka,K. et al, Biochem. Biophys. Res. Commun., 276, 335-345 (2000). PMID: 11006126

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

ICOS*01: AF327184(g)

Nucleotide sequence

1        atgaagccgt acttctgccg tgtctttgtc ttctgcttcc taatcagact tttaacagga

61       gaaatcaatg gctcggccga tcataggatg ttttcatttc acaatggagg tgtacagatt

121      tcttgtaaat accctgagac tgtccagcag ttaaaaatgc gattgttcag agagagagaa

181      gtcctctgcg aactcaccaa gaccaaggga agcggaaatg cggtgtccat caagaatcca

241      atgctctgtc tatatcatct gtcaaacaac agcgtctctt ttttcctaaa caacccagac

301      agctcccagg gaagctatta cttctgcagc ctgtccattt ttgacccacc tccttttcaa

361      gaaaggaacc ttagtggagg atatttgcat atttatgaat cccagctctg ctgccagctg

421      aagctctggc tacccgtagg gtgtgcagct ttcgttgtgg tactcctttt tggatgcata

481      cttatcatct ggttttcaaa aaagaaatac ggatccagtg tgcatgaccc taatagtgaa

541      tacatgttca tggcggcagt caacacaaac aaaaagtcta gacttgcagg tgtgacctca

601      taa
Nucleotide sequence in FASTA format (without gaps) ICOS*01

Amino acid sequence

1        MKPYFCRVFV FCFLIRLLTG EINGSADHRM FSFHNGGVQI SCKYPETVQQ LKMRLFRERE

61       VLCELTKTKG SGNAVSIKNP MLCLYHLSNN SVSFFLNNPD SSQGSYYFCS LSIFDPPPFQ

121      ERNLSGGYLH IYESQLCCQL KLWLPVGCAA FVVVLLFGCI LIIWFSKKKY GSSVHDPNSE

181      YMFMAAVNTN KKSRLAGVTS *
Amino acid sequence in FASTA format (without gap) ICOS*01

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