Authors are encouraged to check their sequences, if appropriate, with IMGT/V-QUEST before submitting them to EMBL, GenBank or DDBJ.
The unique source of data for IMGT/LIGM-DB is EMBL which shares data with the other two generalist databases GenBank and DDBJ. IMGT/LIGM-DB contains the IG and TR sequences which are allowed by the authors to be made public.
LIGM automatically retrieves by FTP IG and TR sequences from EBI, the European Bioinformatics Institute. After control by LIGM curators, data are scanned to store sequences, bibliographical references and taxonomic data, and standardized IMGT/LIGM-DB keywords are assigned to all entries. Based on expert analysis, specific detailed annotations are added to the IMGT/LIGM-DB flat files, according to the IMGT Scientific chart rules, based on IMGT-ONTOLOGY.
Since August 1996, the IMGT/LIGM-DB content closely follows the EMBL one for the IG and TR, with the following advantages: IMGT/LIGM-DB does not contain sequences which have previously been wrongly assigned to IG and TR; conversely, IMGT/LIGM-DB contains IG and TR entries which have disappeared from the generalist databases, as examples:
List of the accession numbers of the 20 IG and TR sequences for which the IMGT team noticed the disappearance from the GenBank release, in February 2000 (e-mail from Marie-Paule Lefranc to Jim Ostell, on the 11/02/2000). These sequences were also deleted from EMBL and DDBJ.
Except for Z75464, which was rightly deleted, the flat files of the other sequences were reintroduced in GenBank and in EMBL/DDBJ in March-April 2000.
Marie-Paule Lefranc, IMGT founder and director (Marie-Paule.Lefranc@igh.cnrs.fr)