Human (Homo sapiens) IGH locus at 14q32.33

• The human IGH locus is located at the telomeric extremity of the long arm of chromosome 14 at 14q32.33.

• The human IGH locus is in reverse orientation: being located on the chromosome long arm, the 5' end of the locus is telomeric and the 3' end is centromeric.

• In IMGT/GeneSearch, IMGT/GeneView and IMGT/LocusView:
  
  
  • The IGH locus starts with the 5' end of AB019437.
  
  
  • Clones (in blue) are those used for the sequencing of the human IGH locus. Note that only part of AC084717 (continuous DNA sequence from 1 to 46566 bp) has been taken into account. The localization of the IGHC genes between IGHG3 and IGHA1, and between IGHG2 and IGHA2 is from cosmid analysis [1]. The distance between the IGHA1 and IGHG2, estimated to 100 kb, and the IGHGP gene localization between IGHA1 and IGHG2, are from IGHC multigene deletions analysis in healthy individuals [2, 3, 4].
    The distance between IGHE-CH4 and IGHE-M1 is estimated to 2,5 kb.
  
  
  • IMGT reference sequences clones and accession numbers are available in IMGT/GENE-DB and in Gene tables  (IMGT Repertoire).
  
  
  • Number of genes in the IMGT genome analysis tools

• Particularities of the pseudogene delimitations:
  
  
  • IGHV(III)-82, -76-1: the 5' limit is that of the V-REGION, there is no INIT-CODON, no L-PART1 and no L-PART2. The 3' limit is that of the V-REGION, there is no V-RS (no V-HEPTAMER, no V-SPACER and no V-NONAMER).
    
    
  • IGHV(II)-15-1, -22-1, -26-2, -28-1, -30-1, -33-1, -40-1, -43-1, -44-2, -46-1, -49-1, -51-2, -53-1, -74-1; IGHV(III)-5-1, -11-1, -16-1, -25-1, -26-1, -47-1, -51-1, -67-4: the 5' limit is that of the V-EXON, there is no INIT-CODON, no L-PART1 and no L-PART2. The 3' limit is that of the V-EXON, there is no V-RS.
    
    
  • IGHV1-12; IGHV3-30-2, -33-2, -36, -42, -50, -79, IGHV4-80; IGHV7-27; IGHV(III)-22-2: the 3' limit is that of the V-REGION there is no V-RS.
    
    
  • IGHV1-14, IGHV3-14; IGHV(II)-62-1, -78-1: the 5' limit is that of the V-REGION, there is no INIT-CODON, no L-PART1 and no L-PART2.
    
    
  • IGHV(III)-44: the 3' limit is that of the V-EXON, there is no V-RS.
    
    
  • IGHV(III)-38-1, IGHV7-40; IGHV(III)-2-1, -5-2, -38-1: the 5' limit is that of the V-EXON, there is no INIT-CODON, no L-PART1 and no L-PART2.
    
    
  • IGHV(III)-13-1: the 5' limit is that of the ACCEPTOR-SPLICE of the V-EXON, there is no INIT-CODON, no L-PART1 and no L-PART2.

See also:

-> IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView and IMGT/CloneSearch Documentation
-> IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView and IMGT/CloneSearch Query page

Contact: Marie-Paule Lefranc

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For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

     

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