]> http://www.w3.org/TR/skos-reference/skos-owl1-dl.rdf http://protege.stanford.edu/plugins/owl/dc/protege-dc.owl http://protege.stanford.edu/plugins/owl/protege Marie-Paule Lefranc IMGT-ONTOLOGY manages the immunogenetics knowledge through diverse facets that rely on the seven axioms of the Formal IMGT-ONTOLOGY, or IMGT-Kaleidoscope: "IDENTIFICATION", "CLASSIFICATION", "DESCRIPTION", "NUMEROTATION", "LOCALIZATION", "ORIENTATION" and "OBTENTION". These axioms postulate that any object, any process and any relation have to be identified, classified, described, numbered, localized and orientated, and that the way it is obtained can be characterized. As the same axioms can be used to generate concepts for multi-scale level approaches, the Formal IMGT-ONTOLOGY represents a paradigm for system biology ontologies, which need to identify, to classify, to describe, to number, to localize and to orientate objects, processes and relations at the molecule, cell, tissue, organ, organism or population levels. IMGT-ONTOLOGY is the first ontology for immunogenetics and immunoinformatics and the global reference in the domain. It was created as early as in 1989 to manage the complexity of immunogenetics data in IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org). IMGT-ONTOLOGY provides a semantic specification of the terms to be used in immunogenetics and immunoinformatics and manages the related knowledge, thus allowing the standardization for immunogenetics data from genome, proteome, genetics, two-dimensional (2D) and three-dimensional (3D) structures. 1.0.1 IMGT-ONTOLOGY Véronique Giudicelli #AA-chain true #AA-chain imgt_000009 #AA-chain AA-chain #AA-chain Identifies, for protein, molecule entities without a leader L region (mature form) and with a conventional region in undefined configuration. AA-chain is in undefined configuration. #Breed true #Breed imgt_000101 #Breed Breed #Breed Allows to identify an interbred variant group inside a subspecies or species, for domestic animals. #C-gene true #C-gene imgt_000010 #C-gene C-gene #C-gene Identifies, for gDNA, molecule entities with a C gene in undefined configuration. C-gene is in undefined configuration. #C-sequence true #C-sequence imgt_000011 #C-sequence C-sequence #C-sequence Identifies, for cDNA, molecule entities with a C region in undefined configuration. C-sequence is in germline configuration. #C-transcript true #C-transcript imgt_000012 #C-transcript C-transcript #C-transcript Identifies, for mRNA, molecule entities with a C region in undefined configuration. C-transcript is in undefined configuration. #CD3 imgt_000289 #CD3 CD3 #CD3 Identifies coreceptor proteins, part of the T cell receptor (TcR) at the T cell surface. Includes CD3 gamma (CD3G), CD3 delta (CD3D), CD3 epsilon (CD3E) and CD3 zeta (CD3Z). #CD79 imgt_000290 #CD79 CD79 #CD79 Identifies coreceptor proteins, part of the B cell receptor (BcR) at the B cell surface. Includes CD79A and CD79B. #CPCA-Chain imgt_000314 #CPCA-Chain #MolecularComponentLevelChainType #CPCA-Chain CPCA-Chain #CPCA-Chain Identifies a composite protein for clinical applications (CPCA) chain. #ChainType true #ChainType imgt_000114 #ChainType It is one of the most important concepts of identification for the standardization of genome, transcriptome and proteome data in system biology. #ChainType ChainType #ChainType The "ChainType" concept allows to identify the type of chain. "ChainType" is a highconcept: it contains a hierarchy of concepts, each of them having a given Level of granularity. #ClassLevelChainType true #ClassLevelChainType imgt_000155 #ClassLevelChainType ClassLevelChainType #ClassLevelChainType Identifies a chain type at the level of the class (for IG and MH). #ClassType true #ClassType imgt_000277 #ClassType ClassType #ClassType The "ClassType" concept allows to identify the type of class of a receptor (IG or MH). #Cluster_of_Differentiation true #Cluster_of_Differentiation imgt_000311 #Cluster_of_Differentiation Cluster_of_Differentiation #Cluster_of_Differentiation Identifies proteins defined in the cluster of differentiation (CD) nomenclatures (originally defined as cluster of cell surface molecules identified by specific monoclonal antibodies). #ConfigurationType true #ConfigurationType imgt_000002 #ConfigurationType ConfigurationType #ConfigurationType The "ConfigurationType" concept allows to identify, whatever the molecule type (gDNA, cDNA, mRNA or protein), the type of configuration of a gene, and by extension, the type of configuration of the Molecule_EntityType leafconcepts that contain it. #D-J-C-sequence true #D-J-C-sequence imgt_000015 #D-J-C-sequence D-J-C-sequence #D-J-C-sequence Identifies, for cDNA, molecule entities with a partially_rearranged D region, a rearranged J region and a C region in undefined configuration. D-J-C-sequence is in partially_rearranged configuration. #D-J-C-transcript true #D-J-C-transcript imgt_000016 #D-J-C-transcript D-J-C-transcript #D-J-C-transcript Identifies, for mRNA, molecule entities with a partially_rearranged D, a rearranged J region and a C region in undefined configuration. D-J-C-transcript is in partially_rearranged configuration. #D-J-gene true #D-J-gene imgt_000017 #D-J-gene D-J-gene #D-J-gene Identifies, for gDNA, molecule entities with a partially_rearranged D gene and a rearranged J gene. D-J-gene is in partially_rearranged configuration. #D-gene true #D-gene imgt_000014 #D-gene D-gene #D-gene Identifies, for gDNA, molecule entities with a germline D gene. D-gene is in germline configuration. #D-sequence true #D-sequence imgt_000018 #D-sequence D-sequence #D-sequence Identifies, for cDNA, molecule entities with a germline D region. D-sequence is in germline configuration. #D-transcript true #D-transcript imgt_000019 #D-transcript D-transcript #D-transcript Identifies for mRNA molecule entities with a germline D region. D-transcript is in germline configuration. #EntityType true #EntityType imgt_000007 #EntityType EntityType #EntityType The "EntityType concept" allows to identify the type of entity. An entity can be a molecule, a cell, a tissue, an organ, an organism or a population. #EthnicGroup true #EthnicGroup imgt_000102 #EthnicGroup EthnicGroup #EthnicGroup Allows to identify an ethnic group inside the Homo sapiens species. #FPIA-Chain imgt_000315 #FPIA-Chain #MolecularComponentLevelChainType #FPIA-Chain FPIA-Chain #FPIA-Chain Identifies a fusion protein for immune applications (FPIA) chain. #Fab imgt_000282 #Fab Fab #Fab Identifies the fragment antigen binding of an IG (or antibody) obtained by papain digestion or in vitro construct. An Fab consists of the Fd (VH+CH1) heavy chain fragment linked by a disulfide bond to the light chain (VL+CL). #Fc imgt_000279 #Fc Fc #Fc Identifies the fragment crystallisable of an IG (or antibody) obtained by papain digestion or in vitro construct. An Fc consists of the two identical hinge+CH2+CH3 heavy chain fragments linked by disulfide bridge(s). #Fc_receptor imgt_000291 #Fc_receptor Fc_receptor #Fc_receptor FcR #Fc_receptor Identifies a family of membrane receptors that binds the Fc of an antibody. They are members of the IgSF superfamily except FCGRT that is a member of the MhSF superfamily. They provide a link between the innate and adaptative immune responses. #Fd imgt_000284 #Fd Fd #Fd Identifies the VH+CH1 fragment of an IG (or antibody) heavy chain. #FormatType true #FormatType imgt_000278 #FormatType FormatType #FormatType The "FormatType" concept allows to identify the type of format of EntityType leafconcepts. #FunctionalityType true #FunctionalityType imgt_000045 #FunctionalityType FunctionalityType #FunctionalityType The "FunctionalityType" concept allows to identify the type of functionality of EntityType leafconcepts. #Fv imgt_000283 #Fv Fv #Fv Identifies the VH and VL domains of an IG (or antibody), or the two domains of a TR, held together by strong noncovalent interactions. #GeneLevelChainType true #GeneLevelChainType imgt_000115 #GeneLevelChainType By convention, the gene name (in capital letters) is added in the name of the ChainType concept at the level "GeneLevelChainType".These concepts of ChainType represent the major concepts for a very precise identification of the chains because they establish a relationship with the "Gene" concept of classification (reciprocal relations "is_coded_by" and "codes"). The number of chainType leafconcepts at the level "GeneLevelChainType" depends on the number of functional and ORF genes per haploid genome in a given species (in the case of the IG and TR genes, it is the number of functional and ORF constant genes which defines the number of leafconcepts). #GeneLevelChainType GeneLevelChainType #GeneLevelChainType Identifies a chain type at the gene level. #GeneType true #GeneType imgt_000052 #GeneType It comprises six leafconcepts. 'conventional_with_leader' and 'conventional_without_leader' identify any (coding or not coding) gene, with or without leader L region (or signal peptide), respectively, other than the immunoglobulin (IG) or T cell receptor (TR) genes of the vertebrate adaptive immune response. The other four leafconcepts refer to the IG and TR genes and are specific to immunogenetics: three of these leafconcepts, 'variable' (V), 'diversity' (D) and 'joining' (J) identify the IG and TR genes that rearrange at the DNA level in the B and T cells and code the V, D and J regions, respectively, of the IG and TR variable domains; the fourth leafconcept, 'constant' (C), identifies the IG and TR genes that code the C region of the IG and TR chains. #GeneType GeneType #GeneType The "GeneType" concept allows to identify the type of gene. #IDENTIFICATION true #IDENTIFICATION imgt_000001 #IDENTIFICATION IDENTIFICATION #IDENTIFICATION The IDENTIFICATION axiom of the Formal IMGT-ONTOLOGY or IMGT-Kaleidoscope postulates that molecules, cells, tissues, organs, organisms or populations, their processes and relations, have to be identified. The IDENTIFICATION axiom has generated the concepts of identification which provide the terms and rules to identify an entity, its processes and its relations. In molecular biology, the concepts of identification allow to identify the molecular components, the molecules, their processes and their relations at the genome, transcriptome, proteome, structure and function levels. #IG-Chain true #IG-Chain imgt_000189 #IG-Chain #MolecularComponentLevelChainType #IG-Chain IG-Chain #IG-Chain Identifies an immunoglobulin (IG) chain. #IG-Heavy-Alpha-1-IGHA1-Chain imgt_000116 #IG-Heavy-Alpha-1-IGHA1-Chain #GeneLevelChainType #IG-Heavy-Alpha-1-IGHA1-Chain IG-Heavy-Alpha-1-IGHA1-Chain #IG-Heavy-Alpha-1-IGHA1-Chain Identifies an Immunoglobulin Heavy Alpha-1 IGHA1 chain. #IG-Heavy-Alpha-2-IGHA2-Chain imgt_000117 #IG-Heavy-Alpha-2-IGHA2-Chain #GeneLevelChainType #IG-Heavy-Alpha-2-IGHA2-Chain IG-Heavy-Alpha-2-IGHA2-Chain #IG-Heavy-Alpha-2-IGHA2-Chain Identifies an Immunoglobulin Heavy Alpha-2 IGHA2 chain. #IG-Heavy-Alpha-Chain true #IG-Heavy-Alpha-Chain imgt_000156 #IG-Heavy-Alpha-Chain #ClassLevelChainType #IG-Heavy-Alpha-Chain IG-Heavy-Alpha-Chain #IG-Heavy-Alpha-Chain Identifies an Immunoglobulin Heavy Alpha chain. #IG-Heavy-Delta-Chain imgt_000157 #IG-Heavy-Delta-Chain #ClassLevelChainType #IG-Heavy-Delta-Chain IG-Heavy-Delta-Chain #IG-Heavy-Delta-Chain Identifies an Immunoglobulin Heavy Delta chain. #IG-Heavy-Delta-IGHD-Chain imgt_000118 #IG-Heavy-Delta-IGHD-Chain #GeneLevelChainType #IG-Heavy-Delta-IGHD-Chain IG-Heavy-Delta-IGHD-Chain #IG-Heavy-Delta-IGHD-Chain Identifies an Immunoglobulin Heavy Delta IGHD chain. #IG-Heavy-Epsilon-Chain imgt_000158 #IG-Heavy-Epsilon-Chain #ClassLevelChainType #IG-Heavy-Epsilon-Chain IG-Heavy-Epsilon-Chain #IG-Heavy-Epsilon-Chain Identifies an Immunoglobulin Heavy Epsilon chain. #IG-Heavy-Epsilon-IGHE-Chain imgt_000119 #IG-Heavy-Epsilon-IGHE-Chain #GeneLevelChainType #IG-Heavy-Epsilon-IGHE-Chain IG-Heavy-Epsilon-IGHE-Chain #IG-Heavy-Epsilon-IGHE-Chain Identifies an Immunoglobulin Heavy Epsilon IGHE chain. #IG-Heavy-Gamma-1-IGHG1-Chain imgt_000120 #IG-Heavy-Gamma-1-IGHG1-Chain #GeneLevelChainType #IG-Heavy-Gamma-1-IGHG1-Chain IG-Heavy-Gamma-1-IGHG1-Chain #IG-Heavy-Gamma-1-IGHG1-Chain Identifies an Immunoglobulin Heavy Gamma-1 IGHG1 chain. #IG-Heavy-Gamma-2-IGHG2-Chain imgt_000124 #IG-Heavy-Gamma-2-IGHG2-Chain #GeneLevelChainType #IG-Heavy-Gamma-2-IGHG2-Chain IG-Heavy-Gamma-2-IGHG2-Chain #IG-Heavy-Gamma-2-IGHG2-Chain Identifies an Immunoglobulin Heavy Gamma-2 IGHG2 chain. #IG-Heavy-Gamma-2-a-IGHG2A-Chain imgt_000121 #IG-Heavy-Gamma-2-a-IGHG2A-Chain #GeneLevelChainType #IG-Heavy-Gamma-2-a-IGHG2A-Chain IG-Heavy-Gamma-2-a-IGHG2A-Chain #IG-Heavy-Gamma-2-a-IGHG2A-Chain Identifies an Immunoglobulin Heavy Gamma-2-a IGHG2A chain. #IG-Heavy-Gamma-2-b-IGHG2B-Chain imgt_000122 #IG-Heavy-Gamma-2-b-IGHG2B-Chain #GeneLevelChainType #IG-Heavy-Gamma-2-b-IGHG2B-Chain IG-Heavy-Gamma-2-b-IGHG2B-Chain #IG-Heavy-Gamma-2-b-IGHG2B-Chain Identifies an Immunoglobulin Heavy Gamma-2-b IGHG2B chain. #IG-Heavy-Gamma-2-c-IGHG2C-Chain imgt_000123 #IG-Heavy-Gamma-2-c-IGHG2C-Chain #GeneLevelChainType #IG-Heavy-Gamma-2-c-IGHG2C-Chain IG-Heavy-Gamma-2-c-IGHG2C-Chain #IG-Heavy-Gamma-2-c-IGHG2C-Chain Identifies an Immunoglobulin Heavy Gamma-2-c IGHG2C chain. #IG-Heavy-Gamma-3-IGHG3-Chain imgt_000125 #IG-Heavy-Gamma-3-IGHG3-Chain #GeneLevelChainType #IG-Heavy-Gamma-3-IGHG3-Chain IG-Heavy-Gamma-3-IGHG3-Chain #IG-Heavy-Gamma-3-IGHG3-Chain Identifies an Immunoglobulin Heavy Gamma-3 IGHG3chain. #IG-Heavy-Gamma-4-IGHG4-Chain imgt_000126 #IG-Heavy-Gamma-4-IGHG4-Chain #GeneLevelChainType #IG-Heavy-Gamma-4-IGHG4-Chain IG-Heavy-Gamma-4-IGHG4-Chain #IG-Heavy-Gamma-4-IGHG4-Chain Identifies an Immunoglobulin Heavy Gamma-4 IGHG4 chain. #IG-Heavy-Gamma-Chain true #IG-Heavy-Gamma-Chain imgt_000159 #IG-Heavy-Gamma-Chain #ClassLevelChainType #IG-Heavy-Gamma-Chain IG-Heavy-Gamma-Chain #IG-Heavy-Gamma-Chain Identifies an Immunoglobulin Heavy Gamma chain. #IG-Heavy-IGH-Chain true #IG-Heavy-IGH-Chain imgt_000174 #IG-Heavy-IGH-Chain #ReceptorLevelChainType #IG-Heavy-IGH-Chain IG-Heavy-IGH-Chain #IG-Heavy-IGH-Chain Identifies an Immunoglobulin Heavy IGH chain. #IG-Heavy-Mu-Chain imgt_000161 #IG-Heavy-Mu-Chain #ClassLevelChainType #IG-Heavy-Mu-Chain IG-Heavy-Mu-Chain #IG-Heavy-Mu-Chain Identifies an Immunoglobulin Heavy Mu chain. #IG-Heavy-Mu-IGHM-Chain imgt_000127 #IG-Heavy-Mu-IGHM-Chain #GeneLevelChainType #IG-Heavy-Mu-IGHM-Chain IG-Heavy-Mu-IGHM-Chain #IG-Heavy-Mu-IGHM-Chain Identifies an Immunoglobulin Heavy Mu IGHM chain. #IG-Heavy-Nu-Chain imgt_000162 #IG-Heavy-Nu-Chain #ClassLevelChainType #IG-Heavy-Nu-Chain IG-Heavy-Nu-Chain #IG-Heavy-Nu-Chain Identifies an Immunoglobulin Heavy Nu chain. #IG-Heavy-Omega-Chain imgt_000163 #IG-Heavy-Omega-Chain #ClassLevelChainType #IG-Heavy-Omega-Chain IG-Heavy-Omega-Chain #IG-Heavy-Omega-Chain Identifies an Immunoglobulin Heavy Omega chain. #IG-Heavy-Phi-Chain imgt_000312 #IG-Heavy-Phi-Chain #ClassLevelChainType #IG-Heavy-Phi-Chain IG-Heavy-Phi-Chain #IG-Heavy-Phi-Chain Identifies an Immunoglobulin Heavy Phi chain. #IG-Heavy-Pi-Chain imgt_000313 #IG-Heavy-Pi-Chain #ClassLevelChainType #IG-Heavy-Pi-Chain IG-Heavy-Pi-Chain #IG-Heavy-Pi-Chain Identifies an Immunoglobulin Heavy Pi chain. #IG-Heavy-Rho-Chain imgt_000164 #IG-Heavy-Rho-Chain #ClassLevelChainType #IG-Heavy-Rho-Chain IG-Heavy-Rho-Chain #IG-Heavy-Rho-Chain Identifies an Immunoglobulin Heavy Rho chain. #IG-Heavy-Tau-Chain imgt_000165 #IG-Heavy-Tau-Chain #ClassLevelChainType #IG-Heavy-Tau-Chain IG-Heavy-Tau-Chain #IG-Heavy-Tau-Chain Identifies an Immunoglobulin Heavy Tau chain. #IG-Heavy-Upsilon-Chain imgt_000166 #IG-Heavy-Upsilon-Chain #ClassLevelChainType #IG-Heavy-Upsilon-Chain IG-Heavy-Upsilon-Chain #IG-Heavy-Upsilon-Chain Identifies an Immunoglobulin Heavy Upsilon chain. #IG-Heavy-Xi-Chain imgt_000160 #IG-Heavy-Xi-Chain #ClassLevelChainType #IG-Heavy-Xi-Chain IG-Heavy-Xi-Chain #IG-Heavy-Xi-Chain Identifies an Immunoglobulin Heavy Xi chain. #IG-Heavy-Zeta-Chain imgt_000167 #IG-Heavy-Zeta-Chain #ClassLevelChainType #IG-Heavy-Zeta-Chain IG-Heavy-Zeta-Chain #IG-Heavy-Zeta-Chain Identifies an Immunoglobulin Heavy Zeta chain. #IG-Light-Chain true #IG-Light-Chain imgt_000175 #IG-Light-Chain #ReceptorLevelChainType #IG-Light-Chain IG-Light-Chain #IG-Light-Chain Identifies an Immunoglobulin Light chain. #IG-Light-Iota-IGI-Chain imgt_000168 #IG-Light-Iota-IGI-Chain #ClassLevelChainType #IG-Light-Iota-IGI-Chain IG-Light-Iota-IGI-Chain #IG-Light-Iota-IGI-Chain Identifies an Immunoglobulin Light Iota chain. #IG-Light-Kappa-IGK-Chain imgt_000169 #IG-Light-Kappa-IGK-Chain #ClassLevelChainType #IG-Light-Kappa-IGK-Chain IG-Light-Kappa-IGK-Chain #IG-Light-Kappa-IGK-Chain Identifies an Immunoglobulin Light Kappa chain. #IG-Light-Kappa-IGKC-Chain imgt_000128 #IG-Light-Kappa-IGKC-Chain #GeneLevelChainType #IG-Light-Kappa-IGKC-Chain IG-Light-Kappa-IGKC-Chain #IG-Light-Kappa-IGKC-Chain Identifies an Immunoglobulin Light Kappa IGKC chain. #IG-Light-Lambda-1-IGLC1-Chain imgt_000129 #IG-Light-Lambda-1-IGLC1-Chain #GeneLevelChainType #IG-Light-Lambda-1-IGLC1-Chain IG-Light-Lambda-1-IGLC1-Chain #IG-Light-Lambda-1-IGLC1-Chain Identifies an Immunoglobulin Light Lambda-1 IGLC1 chain. #IG-Light-Lambda-2-IGLC2-Chain imgt_000130 #IG-Light-Lambda-2-IGLC2-Chain #GeneLevelChainType #IG-Light-Lambda-2-IGLC2-Chain IG-Light-Lambda-2-IGLC2-Chain #IG-Light-Lambda-2-IGLC2-Chain Identifies an Immunoglobulin Light Lambda-2 IGLC2 chain. #IG-Light-Lambda-3-IGLC3-Chain imgt_000131 #IG-Light-Lambda-3-IGLC3-Chain #GeneLevelChainType #IG-Light-Lambda-3-IGLC3-Chain IG-Light-Lambda-3-IGLC3-Chain #IG-Light-Lambda-3-IGLC3-Chain Identifies an Immunoglobulin Light Lambda-3 IGLC3 chain. #IG-Light-Lambda-6-IGLC6-Chain imgt_000132 #IG-Light-Lambda-6-IGLC6-Chain #GeneLevelChainType #IG-Light-Lambda-6-IGLC6-Chain IG-Light-Lambda-6-IGLC6-Chain #IG-Light-Lambda-6-IGLC6-Chain Identifies an Immunoglobulin Light Lambda-6 IGLC6 chain. #IG-Light-Lambda-7-IGLC7-Chain imgt_000133 #IG-Light-Lambda-7-IGLC7-Chain #GeneLevelChainType #IG-Light-Lambda-7-IGLC7-Chain IG-Light-Lambda-7-IGLC7-Chain #IG-Light-Lambda-7-IGLC7-Chain Identifies an Immunoglobulin Light Lambda-7 IGLC7 chain. #IG-Light-Lambda-IGL-Chain true #IG-Light-Lambda-IGL-Chain imgt_000170 #IG-Light-Lambda-IGL-Chain #ClassLevelChainType #IG-Light-Lambda-IGL-Chain IG-Light-Lambda-IGL-Chain #IG-Light-Lambda-IGL-Chain Identifies an Immunoglobulin Light Lambda chain. #IG-Light-Rho-IGR-Chain imgt_000171 #IG-Light-Rho-IGR-Chain #ClassLevelChainType #IG-Light-Rho-IGR-Chain IG-Light-Rho-IGR-Chain #IG-Light-Rho-IGR-Chain Identifies an Immunoglobulin Light Rho chain. #IG-Light-Sigma-IGS-Chain imgt_000172 #IG-Light-Sigma-IGS-Chain #ClassLevelChainType #IG-Light-Sigma-IGS-Chain IG-Light-Sigma-IGS-Chain #IG-Light-Sigma-IGS-Chain Identifies an Immunoglobulin Light Sigma chain. #IG_Class true #IG_Class imgt_000196 #IG_Class IG_Class #IG_Class Identifies an IG class. #IgA1_kappa_Subclass imgt_000208 #IgA1_kappa_Subclass #GeneLevelChainType #IgA1_kappa_Subclass IgA1_kappa_Subclass #IgA1_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-1-IGHA1-Chain and two IG-Light-Kappa-IGKC-Chain. #IgA1_lambda-1_Subclass imgt_000209 #IgA1_lambda-1_Subclass #GeneLevelChainType #IgA1_lambda-1_Subclass IgA1_lambda-1_Subclass #IgA1_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-1-IGHA1-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgA1_lambda-2_Subclass imgt_000210 #IgA1_lambda-2_Subclass #GeneLevelChainType #IgA1_lambda-2_Subclass IgA1_lambda-2_Subclass #IgA1_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-1-IGHA1-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgA1_lambda-3_Subclass imgt_000211 #IgA1_lambda-3_Subclass #GeneLevelChainType #IgA1_lambda-3_Subclass IgA1_lambda-3_Subclass #IgA1_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-1-IGHA1-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgA1_lambda-6_Subclass imgt_000212 #IgA1_lambda-6_Subclass #GeneLevelChainType #IgA1_lambda-6_Subclass IgA1_lambda-6_Subclass #IgA1_lambda-6_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-1-IGHA1-Chain and two IG-Light-Lambda-6-IGLC6-Chain. #IgA1_lambda-7_Subclass imgt_000213 #IgA1_lambda-7_Subclass #GeneLevelChainType #IgA1_lambda-7_Subclass IgA1_lambda-7_Subclass #IgA1_lambda-7_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-1-IGHA1-Chain and two IG-Light-Lambda-7-IGLC7-Chain. #IgA2_kappa_Subclass imgt_000214 #IgA2_kappa_Subclass #GeneLevelChainType #IgA2_kappa_Subclass IgA2_kappa_Subclass #IgA2_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-2-IGHA2-Chain and two IG-Light-Kappa-IGKC-Chain. #IgA2_lambda-1_Subclass imgt_000215 #IgA2_lambda-1_Subclass #GeneLevelChainType #IgA2_lambda-1_Subclass IgA2_lambda-1_Subclass #IgA2_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-2-IGHA2-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgA2_lambda-2_Subclass imgt_000216 #IgA2_lambda-2_Subclass #GeneLevelChainType #IgA2_lambda-2_Subclass IgA2_lambda-2_Subclass #IgA2_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-2-IGHA2-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgA2_lambda-3_Subclass imgt_000217 #IgA2_lambda-3_Subclass #GeneLevelChainType #IgA2_lambda-3_Subclass IgA2_lambda-3_Subclass #IgA2_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-2-IGHA2-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgA2_lambda-6_Subclass imgt_000218 #IgA2_lambda-6_Subclass #GeneLevelChainType #IgA2_lambda-6_Subclass IgA2_lambda-6_Subclass #IgA2_lambda-6_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-2-IGHA2-Chain and two IG-Light-Lambda-6-IGLC6-Chain. #IgA2_lambda-7_Subclass imgt_000219 #IgA2_lambda-7_Subclass #GeneLevelChainType #IgA2_lambda-7_Subclass IgA2_lambda-7_Subclass #IgA2_lambda-7_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Alpha-2-IGHA2-Chain and two IG-Light-Lambda-7-IGLC7-Chain. #IgA_kappa_Class true #IgA_kappa_Class imgt_000197 #IgA_kappa_Class #ClassLevelChainType #IgA_kappa_Class IgA_kappa_Class #IgA_kappa_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Alpha-Chain and two IG-Light-Kappa-IGK-Chain. #IgA_lambda_Class true #IgA_lambda_Class imgt_000198 #IgA_lambda_Class #ClassLevelChainType #IgA_lambda_Class IgA_lambda_Class #IgA_lambda_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Alpha-Chain and two IG-Light-Lambda-IGL-Chain. #IgD_kappa_Class imgt_000199 #IgD_kappa_Class #GeneLevelChainType #IgD_kappa_Class IgD_kappa_Class #IgD_kappa_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Delta-IGHD-Chain and two IG-Light-Kappa-IGKC-Chain. #IgD_lambda_Class imgt_000200 #IgD_lambda_Class #ClassLevelChainType #IgD_lambda_Class IgD_lambda_Class #IgD_lambda_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy- Delta-Chain and two IG-Light-Lambda-IGL-Chain. #IgE_kappa_Class imgt_000201 #IgE_kappa_Class #GeneLevelChainType #IgE_kappa_Class IgE_kappa_Class #IgE_kappa_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Epsilon-IGHE-Chain and two IG-Light-Kappa-IGKC-Chain. #IgE_lambda_Class imgt_000202 #IgE_lambda_Class #ClassLevelChainType #IgE_lambda_Class IgE_lambda_Class #IgE_lambda_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy- Epsilon-Chain and two IG-Light-Lambda-IGL-Chain. #IgG1_kappa_Subclass imgt_000220 #IgG1_kappa_Subclass #GeneLevelChainType #IgG1_kappa_Subclass IgG1_kappa_Subclass #IgG1_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-1-IGHG1-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG1_lambda-1_Subclass imgt_000221 #IgG1_lambda-1_Subclass #GeneLevelChainType #IgG1_lambda-1_Subclass IgG1_lambda-1_Subclass #IgG1_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-1-IGHG1-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgG1_lambda-2_Subclass imgt_000222 #IgG1_lambda-2_Subclass #GeneLevelChainType #IgG1_lambda-2_Subclass IgG1_lambda-2_Subclass #IgG1_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-1-IGHG1-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG1_lambda-3_Subclass imgt_000223 #IgG1_lambda-3_Subclass #GeneLevelChainType #IgG1_lambda-3_Subclass IgG1_lambda-3_Subclass #IgG1_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-1-IGHG1-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG1_lambda-6_Subclass imgt_000224 #IgG1_lambda-6_Subclass #GeneLevelChainType #IgG1_lambda-6_Subclass IgG1_lambda-6_Subclass #IgG1_lambda-6_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-1-IGHG1-Chain and two IG-Light-Lambda-6-IGLC6-Chain. #IgG1_lambda-7_Subclass imgt_000225 #IgG1_lambda-7_Subclass #GeneLevelChainType #IgG1_lambda-7_Subclass IgG1_lambda-7_Subclass #IgG1_lambda-7_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-1-IGHG1-Chain and two IG-Light-Lambda-7-IGLC7-Chain. #IgG2_kappa_Subclass imgt_000226 #IgG2_kappa_Subclass #GeneLevelChainType #IgG2_kappa_Subclass IgG2_kappa_Subclass #IgG2_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-IGHG2-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG2_lambda-1_Subclass imgt_000227 #IgG2_lambda-1_Subclass #GeneLevelChainType #IgG2_lambda-1_Subclass IgG2_lambda-1_Subclass #IgG2_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-IGHG2-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgG2_lambda-2_Subclass imgt_000228 #IgG2_lambda-2_Subclass #GeneLevelChainType #IgG2_lambda-2_Subclass IgG2_lambda-2_Subclass #IgG2_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-IGHG2-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG2_lambda-3_Subclass imgt_000229 #IgG2_lambda-3_Subclass #GeneLevelChainType #IgG2_lambda-3_Subclass IgG2_lambda-3_Subclass #IgG2_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-IGHG2-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG2_lambda-6_Subclass imgt_000230 #IgG2_lambda-6_Subclass #GeneLevelChainType #IgG2_lambda-6_Subclass IgG2_lambda-6_Subclass #IgG2_lambda-6_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-IGHG2-Chain and two IG-Light-Lambda-6-IGLC6-Chain. #IgG2_lambda-7_Subclass imgt_000231 #IgG2_lambda-7_Subclass #GeneLevelChainType #IgG2_lambda-7_Subclass IgG2_lambda-7_Subclass #IgG2_lambda-7_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-IGHG2-Chain and two IG-Light-Lambda-7-IGLC7-Chain. #IgG2a_kappa_Subclass imgt_000232 #IgG2a_kappa_Subclass #GeneLevelChainType #IgG2a_kappa_Subclass IgG2a_kappa_Subclass #IgG2a_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-a-IGHG2A-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG2a_lambda-1_Subclass imgt_000233 #IgG2a_lambda-1_Subclass #GeneLevelChainType #IgG2a_lambda-1_Subclass IgG2a_lambda-1_Subclass #IgG2a_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-a-IGHG2A-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgG2a_lambda-2_Subclass imgt_000234 #IgG2a_lambda-2_Subclass #GeneLevelChainType #IgG2a_lambda-2_Subclass IgG2a_lambda-2_Subclass #IgG2a_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-a-IGHG2A-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG2a_lambda-3_Subclass imgt_000235 #IgG2a_lambda-3_Subclass #GeneLevelChainType #IgG2a_lambda-3_Subclass IgG2a_lambda-3_Subclass #IgG2a_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-a-IGHG2A-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG2b_kappa_Subclass imgt_000236 #IgG2b_kappa_Subclass #GeneLevelChainType #IgG2b_kappa_Subclass IgG2b_kappa_Subclass #IgG2b_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-b-IGHG2B-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG2b_lambda-1_Subclass imgt_000237 #IgG2b_lambda-1_Subclass #GeneLevelChainType #IgG2b_lambda-1_Subclass IgG2b_lambda-1_Subclass #IgG2b_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-b-IGHG2B-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgG2b_lambda-2_Subclass imgt_000238 #IgG2b_lambda-2_Subclass #GeneLevelChainType #IgG2b_lambda-2_Subclass IgG2b_lambda-2_Subclass #IgG2b_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-b-IGHG2B-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG2b_lambda-3_Subclass imgt_000239 #IgG2b_lambda-3_Subclass #GeneLevelChainType #IgG2b_lambda-3_Subclass IgG2b_lambda-3_Subclass #IgG2b_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-b-IGHG2B-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG2c_kappa_Subclass imgt_000240 #IgG2c_kappa_Subclass #GeneLevelChainType #IgG2c_kappa_Subclass IgG2c_kappa_Subclass #IgG2c_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-c-IGHG2C-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG2c_lambda-1_Subclass imgt_000241 #IgG2c_lambda-1_Subclass #GeneLevelChainType #IgG2c_lambda-1_Subclass IgG2c_lambda-1_Subclass #IgG2c_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-c-IGHG2C-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgG2c_lambda-2_Subclass imgt_000242 #IgG2c_lambda-2_Subclass #GeneLevelChainType #IgG2c_lambda-2_Subclass IgG2c_lambda-2_Subclass #IgG2c_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-c-IGHG2C-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG2c_lambda-3_Subclass imgt_000243 #IgG2c_lambda-3_Subclass #GeneLevelChainType #IgG2c_lambda-3_Subclass IgG2c_lambda-3_Subclass #IgG2c_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-2-c-IGHG2C-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG3_kappa_Subclass imgt_000244 #IgG3_kappa_Subclass #GeneLevelChainType #IgG3_kappa_Subclass IgG3_kappa_Subclass #IgG3_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-3-IGHG3-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG3_lambda-1_Subclass imgt_000245 #IgG3_lambda-1_Subclass #GeneLevelChainType #IgG3_lambda-1_Subclass IgG3_lambda-1_Subclass #IgG3_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-3-IGHG3-Chain and two IG-Light-Lambda-1-IGLC1-Chain. #IgG3_lambda-2_Subclass imgt_000246 #IgG3_lambda-2_Subclass #GeneLevelChainType #IgG3_lambda-2_Subclass IgG3_lambda-2_Subclass #IgG3_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-3-IGHG3-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG3_lambda-3_Subclass imgt_000247 #IgG3_lambda-3_Subclass #GeneLevelChainType #IgG3_lambda-3_Subclass IgG3_lambda-3_Subclass #IgG3_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-3-IGHG3-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG3_lambda-6_Subclass imgt_000248 #IgG3_lambda-6_Subclass #GeneLevelChainType #IgG3_lambda-6_Subclass IgG3_lambda-6_Subclass #IgG3_lambda-6_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-3-IGHG3-Chain and two IG-Light-Lambda-6-IGLC6-Chain. #IgG3_lambda-7_Subclass imgt_000249 #IgG3_lambda-7_Subclass #GeneLevelChainType #IgG3_lambda-7_Subclass IgG3_lambda-7_Subclass #IgG3_lambda-7_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-3-IGHG3-Chain and two IG-Light-Lambda-7-IGLC7-Chain. #IgG4_kappa_Subclass imgt_000250 #IgG4_kappa_Subclass #GeneLevelChainType #IgG4_kappa_Subclass IgG4_kappa_Subclass #IgG4_kappa_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-4-IGHG4-Chain and two IG-Light-Kappa-IGKC-Chain. #IgG4_lambda-1_Subclass imgt_000251 #IgG4_lambda-1_Subclass #GeneLevelChainType #IgG4_lambda-1_Subclass IgG4_lambda-1_Subclass #IgG4_lambda-1_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-4-IGHG4-Chain and two IG-Light-Lambda-1-IGLC1-Chain #IgG4_lambda-2_Subclass imgt_000252 #IgG4_lambda-2_Subclass #GeneLevelChainType #IgG4_lambda-2_Subclass IgG4_lambda-2_Subclass #IgG4_lambda-2_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-4-IGHG4-Chain and two IG-Light-Lambda-2-IGLC2-Chain. #IgG4_lambda-3_Subclass imgt_000253 #IgG4_lambda-3_Subclass #GeneLevelChainType #IgG4_lambda-3_Subclass IgG4_lambda-3_Subclass #IgG4_lambda-3_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-4-IGHG4-Chain and two IG-Light-Lambda-3-IGLC3-Chain. #IgG4_lambda-6_Subclass imgt_000254 #IgG4_lambda-6_Subclass #GeneLevelChainType #IgG4_lambda-6_Subclass IgG4_lambda-6_Subclass #IgG4_lambda-6_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-4-IGHG4-Chain and two IG-Light-Lambda-6-IGLC6-Chain. #IgG4_lambda-7_Subclass imgt_000255 #IgG4_lambda-7_Subclass #GeneLevelChainType #IgG4_lambda-7_Subclass IgG4_lambda-7_Subclass #IgG4_lambda-7_Subclass Identifies a subclass of IG, the monomer of which is composed by two IG-Heavy-Gamma-4-IGHG4-Chain and two IG-Light-Lambda-7-IGLC7-Chain. #IgG_kappa_Class true #IgG_kappa_Class imgt_000203 #IgG_kappa_Class #ClassLevelChainType #IgG_kappa_Class IgG_kappa_Class #IgG_kappa_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Gamma-Chain and two IG-Light-Kappa-IGK-Chain. #IgG_lambda_Class true #IgG_lambda_Class imgt_000204 #IgG_lambda_Class #ClassLevelChainType #IgG_lambda_Class IgG_lambda_Class #IgG_lambda_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Gamma-Chain and two IG-Light-Lambda-IGL-Chain. #IgM_kappa_Class imgt_000205 #IgM_kappa_Class #GeneLevelChainType #IgM_kappa_Class IgM_kappa_Class #IgM_kappa_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Mu-IGHM-Chain and two IG-Light-Kappa-IGKC-Chain. #IgM_lambda_Class imgt_000206 #IgM_lambda_Class #ClassLevelChainType #IgM_lambda_Class IgM_lambda_Class #IgM_lambda_Class Identifies a class of IG, the monomer of which is composed by two IG-Heavy-Mu-Chain and two IG-Light-Lambda-IGL-Chain. #J-C-gene true #J-C-gene imgt_000020 #J-C-gene J-C-gene #J-C-gene Identifies, for gDNA, molecule entities that are processed (usually orphon) with a germline J gene joined to a C gene in undefined configuration. J-C-gene is in germline configuration. #J-C-sequence true #J-C-sequence imgt_000021 #J-C-sequence J-C-sequence #J-C-sequence Identifies, for cDNA, molecule entities with a germline J region and a C region in undefined configuration. J-C-sequence is in germline configuration. #J-C-transcript true #J-C-transcript imgt_000022 #J-C-transcript J-C-transcript #J-C-transcript Identifies, for mRNA, molecule entities with a germline J region and a C region in undefined configuration. J-C-transcript is in germline configuration. #J-gene true #J-gene imgt_000023 #J-gene J-gene #J-gene Identifies, for gDNA, molecule entities with a germline J gene. J-gene is in germline configuration. #J-sequence true #J-sequence imgt_000024 #J-sequence J-sequence #J-sequence Identifies, for cDNA, molecule entities with a germline J region. J-sequence is in germline configuration. #J-transcript true #J-transcript imgt_000025 #J-transcript J-transcript #J-transcript Identifies, for mRNA, molecule entities with a germline J region. J-transcript is in germline configuration. #Killer_cell_immunoglobulin-like_receptor imgt_000292 #Killer_cell_immunoglobulin-like_receptor Killer_cell_immunoglobulin-like_receptor #Killer_cell_immunoglobulin-like_receptor KIR #Killer_cell_immunoglobulin-like_receptor Identifies a family of membrane receptors (KIR) expressed by natural killer (NK) cells and a subpopulation of T cells, that bind major histocompatibility class I (MH1) proteins. They are members of the IgSF superfamily. #Killer_cell_lectine-like_receptor imgt_000293 #Killer_cell_lectine-like_receptor previously NKG, Natural Killer Group #Killer_cell_lectine-like_receptor Killer_cell_lectine-like_receptor #Killer_cell_lectine-like_receptor KLR #Killer_cell_lectine-like_receptor Identifies a family of receptors of the C type lectine superfamily (KLR). #L-AA-chain true #L-AA-chain imgt_000026 #L-AA-chain L-AA-chain #L-AA-chain Identifies, for protein, molecule entities with a leader L region (immature form) and a conventional region in undefined configuration. AA-chain is in undefined configuration. #L-V-D-J-C-chain true #L-V-D-J-C-chain imgt_000027 #L-V-D-J-C-chain L-V-D-J-C-chain #L-V-D-J-C-chain Identifies, for protein, molecule entities with a leader L region (immature form), a rearranged V region, at least one rearranged D region, a rearranged J region and a C region in undefined configuration. L-V-D-J-C-chain is in rearranged configuration. #L-V-D-J-C-sequence true #L-V-D-J-C-sequence imgt_000028 #L-V-D-J-C-sequence L-V-D-J-C-sequence #L-V-D-J-C-sequence Identifies, for cDNA, molecule entities with a leader L region, a rearranged V region, at least one rearranged D region, a rearranged J region and a C region in undefined configuration. L-V-D-J-C-sequence is in rearranged configuration. #L-V-D-J-C-transcript true #L-V-D-J-C-transcript imgt_000029 #L-V-D-J-C-transcript L-V-D-J-C-transcript #L-V-D-J-C-transcript Identifies, for mRNA, molecule entities with a leader L region, a rearranged V region, at least one rearranged D region, a rearranged J region and a C region in undefined configuration. L-V-D-J-C-transcript is in rearranged configuration. #L-V-D-sequence true #L-V-D-sequence imgt_000030 #L-V-D-sequence L-V-D-sequence #L-V-D-sequence Identifies, for cDNA, molecule entities with a leader L region, a rearranged V region and a partially_rearranged D. L-V-D-sequence is in partially_rearranged configuration. #L-V-D-transcript true #L-V-D-transcript imgt_000031 #L-V-D-transcript L-V-D-transcript #L-V-D-transcript Identifies, for mRNA, molecules entities with a leader L region, a rearranged V region and a partially_rearranged D. L-V-D-transcript is in partially_rearranged configuration. #L-V-J-C-chain true #L-V-J-C-chain imgt_000032 #L-V-J-C-chain L-V-J-C-chain #L-V-J-C-chain Identifies, for protein, molecule entities with a leader L region (immature form), a rearranged V region, a rearranged J region and a C region in undefined configuration. L-V-J-C-chain is in rearranged configuration; #L-V-J-C-sequence true #L-V-J-C-sequence imgt_000033 #L-V-J-C-sequence L-V-J-C-sequence #L-V-J-C-sequence Identifies, for cDNA, molecule entities with a leader L region, a rearranged V region, a rearranged J region and a C region in undefined configuration. L-V-J-C-sequence is in rearranged configuration. #L-V-J-C-transcript true #L-V-J-C-transcript imgt_000034 #L-V-J-C-transcript L-V-J-C-transcript #L-V-J-C-transcript Identifies, for mRNA, molecule entities with a leader L region, a rearranged V region, a rearranged J region and a C region in undefined configuration. L-V-J-C-transcript is in rearranged configuration. #L-V-sequence true #L-V-sequence imgt_000035 #L-V-sequence L-V-sequence #L-V-sequence Identifies, for cDNA, molecule entities with a leader L region and a germline V region. L-V-sequence is in germline configuration. #L-V-transcript true #L-V-transcript imgt_000036 #L-V-transcript L-V-transcript #L-V-transcript Identifies, for mRNA, molecule entities with a leader L region and a germline V region. L-V-transcript is in germline configuration. #L-nt-sequence true #L-nt-sequence imgt_000110 #L-nt-sequence L-nt-sequence #L-nt-sequence Identifies, for cDNA, molecule entities with a leader L region and a conventional region in undefined configuration. L-nt-sequence is in undefined configuration. #L-nt-transcript true #L-nt-transcript imgt_000111 #L-nt-transcript L-nt-transcript #L-nt-transcript Identifies, for mRNA, molecule entities with a leader L region and a conventional region in undefined configuration. L-nt-transcript is in undefined configuration. #Leucocyte_immunoglobulin-like_receptor imgt_000294 #Leucocyte_immunoglobulin-like_receptor Leucocyte_immunoglobulin-like_receptor #Leucocyte_immunoglobulin-like_receptor LILR #Leucocyte_immunoglobulin-like_receptor Identifies a family of leucocyte immunoglobulin-like receptors (LILR) expressed by natural killer (NK) cells. They belong to the IgSF superfamily. #LevelChainType true #LevelChainType imgt_000285 #LevelChainType LevelChainType #LevelChainType Identifies the level of granularity of a ChainType concept in the ChainType highconcept hierarchy. #LocationType true #LocationType imgt_000058 #LocationType LocationType #LocationType The "LocationType" concept allows to identify the type of location of EntityType leafconcepts. #MH-Chain true #MH-Chain imgt_000190 #MH-Chain #MolecularComponentLevelChainType #MH-Chain MH-Chain #MH-Chain Identifies a major histocompatibility (MH) chain. #MH1-Alpha-Chain true #MH1-Alpha-Chain imgt_000176 #MH1-Alpha-Chain #ReceptorLevelChainType #MH1-Alpha-Chain MH1-Alpha-Chain #MH1-Alpha-Chain Identifies a MH1 Alpha chain. #MH1-Alpha-MH1-A-Chain imgt_000304 #MH1-Alpha-MH1-A-Chain #GeneLevelChainType #MH1-Alpha-MH1-A-Chain MH1-Alpha-MH1-A-Chain #MH1-Alpha-MH1-A-Chain Identifies a MH1 Alpha MH1-A chain #MH1-Alpha-MH1-B-Chain imgt_000305 #MH1-Alpha-MH1-B-Chain #GeneLevelChainType #MH1-Alpha-MH1-B-Chain MH1-Alpha-MH1-B-Chain #MH1-Alpha-MH1-B-Chain Identifies a MH1 Alpha MH1-B chain #MH1-Alpha-MH1-C-Chain imgt_000306 #MH1-Alpha-MH1-C-Chain #GeneLevelChainType #MH1-Alpha-MH1-C-Chain MH1-Alpha-MH1-C-Chain #MH1-Alpha-MH1-C-Chain Identifies a MH1 Alpha MH1-C chain #MH1-Alpha-MH1-D-Chain imgt_000307 #MH1-Alpha-MH1-D-Chain #GeneLevelChainType #MH1-Alpha-MH1-D-Chain MH1-Alpha-MH1-D-Chain #MH1-Alpha-MH1-D-Chain Identifies a MH1 Alpha MH1-D chain #MH1-Chain true #MH1-Chain imgt_000193 #MH1-Chain #ClassLevelChainType #MH1-Chain MH1-Chain #MH1-Chain Identifies a MH1 chain. #MH1_Class true #MH1_Class imgt_000257 #MH1_Class #ClassLevelChainType #MH1_Class MH1_Class #MH1_Class Identifies the MH class I or MH1. #MH2-Alpha-Chain true #MH2-Alpha-Chain imgt_000178 #MH2-Alpha-Chain #ReceptorLevelChainType #MH2-Alpha-Chain MH2-Alpha-Chain #MH2-Alpha-Chain Identifies a MH2 Alpha chain. #MH2-Alpha-MH2-DA-Chain imgt_000308 #MH2-Alpha-MH2-DA-Chain #GeneLevelChainType #MH2-Alpha-MH2-DA-Chain MH2-Alpha-MH2-DA-Chain #MH2-Alpha-MH2-DA-Chain Identifies a MH2 Alpha MH2-DA chain #MH2-Beta-Chain true #MH2-Beta-Chain imgt_000179 #MH2-Beta-Chain #ReceptorLevelChainType #MH2-Beta-Chain MH2-Beta-Chain #MH2-Beta-Chain Identifies a MH2 Beta chain. #MH2-Beta-MH2-DB1-Chain imgt_000309 #MH2-Beta-MH2-DB1-Chain #GeneLevelChainType #MH2-Beta-MH2-DB1-Chain MH2-Beta-MH2-DB1-Chain #MH2-Beta-MH2-DB1-Chain Identifies a MH2 Beta MH2-DB1 chain. #MH2-Beta-MH2-DB2-Chain imgt_000310 #MH2-Beta-MH2-DB2-Chain #GeneLevelChainType #MH2-Beta-MH2-DB2-Chain MH2-Beta-MH2-DB2-Chain #MH2-Beta-MH2-DB2-Chain Identifies a MH2 Beta MH2-DB2 chain. #MH2-Chain true #MH2-Chain imgt_000195 #MH2-Chain #ClassLevelChainType #MH2-Chain MH2-Chain #MH2-Chain Identifies a MH2 chain. #MH2_Class true #MH2_Class imgt_000259 #MH2_Class #ClassLevelChainType #MH2_Class MH2_Class #MH2_Class Identifies the MH class II or MH2. #MH_Class true #MH_Class imgt_000256 #MH_Class MH_Class #MH_Class Identifies a MH class. #MolecularComponent true #MolecularComponent imgt_000064 #MolecularComponent MolecularComponent #MolecularComponent The "MolecularComponent" concept allows to identify molecular components. #MolecularComponentLevelChainType true #MolecularComponentLevelChainType imgt_000188 #MolecularComponentLevelChainType MolecularComponentLevelChainType #MolecularComponentLevelChainType Identifies a chain type at the molecular component level. #MoleculeType true #MoleculeType imgt_000068 #MoleculeType MoleculeType #MoleculeType The "MoleculeType" concept allows to identify the type of molecule, based on the type of the constitutive elements and on the concepts of obtention. #MoleculeUnit true #MoleculeUnit imgt_000074 #MoleculeUnit MoleculeUnit #MoleculeUnit The "MoleculeUnit" concept allows to identify a molecule unit. #Molecule_EntityType true #Molecule_EntityType imgt_000008 #Molecule_EntityType There are 38 "Molecule_EntityType" leafconcepts that, based on the "MoleculeType" ('gDNA', 'mRNA', 'cDNA' or 'protein'), identify the molecule entities of the four major "MoleculeUnit" leafconcepts that are genes (10), transcripts (11), cDNA sequences (11) and chains (6) (as indicated by the suffix). #Molecule_EntityType Molecule_EntityType #Molecule_EntityType The "Molecule_EntityType" concept allows to identify the type of molecule entity. The "Molecule_EntityType" concept is defined by the "MoleculeType", "GeneType" and "ConfigurationType" concepts of identification and has properties identified in the "Molecule_FunctionalityType" and "Molecule_StructureType" concepts. #Molecule_FunctionalityType true #Molecule_FunctionalityType imgt_000046 #Molecule_FunctionalityType Three leafconcepts, 'functional', 'ORF' (Open Reading Frame) and 'pseudogene', identify the functionality of Molecule_EntityType leafconcepts in undefined configuration (conventional genes and IG and TR constant (C) genes) or in germline configuration (IG and TR variable (V), diversity (D) and joining (J) genes before DNA rearrangements). Two leafconcepts, 'productive' and 'unproductive', identify the functionality of Molecule_EntityType leafconcepts in rearranged or partially_rearranged configuration (IG and TR entities after DNA rearrangements, and by extension fusion entities resulting from translocations, and hybrid entities obtained by biotechnology molecular engineering). #Molecule_FunctionalityType Molecule_FunctionalityType #Molecule_FunctionalityType The "Molecule_FunctionalityType" concept allows to identify, whatever the molecule type (gDNA, cDNA, mRNA or protein), the type of functionality of a Molecule_EntityType leafconcept. #Molecule_LocationType true #Molecule_LocationType imgt_000059 #Molecule_LocationType Molecule_LocationType #Molecule_LocationType The "Molecule_LocationType" concept allows to identify, whatever the molecule type (gDNA, cDNA, mRNA or protein), the Molecule_EntityType leafconcepts based on their location. #Molecule_StructureType true #Molecule_StructureType imgt_000082 #Molecule_StructureType Molecule_StructureType #Molecule_StructureType The "Molecule_StructureType" concept allows to identify, whatever the molecule type (gDNA, cDNA, mRNA or protein), the structure of Molecule_EntityType leafconcepts. #ORF true #ORF imgt_000048 #ORF ORF #ORF Identifies, whatever the molecule type, the functionality of Molecule_EntityType leafconcepts in undefined or germline configuration, whose coding region has an open reading frame (ORF), but: * alterations have been described in the splicing sites, recombination signals and/or regulatory elements. * and/or changes of conserved amino acids have been suggested by the authors to lead to uncorrect folding. * and/or the entity is an orphon. #RPI-Beta2microglobulin-B2M-Chain imgt_000139 #RPI-Beta2microglobulin-B2M-Chain #GeneLevelChainType #RPI-Beta2microglobulin-B2M-Chain RPI-Beta2microglobulin-B2M-Chain #RPI-Beta2microglobulin-B2M-Chain Identifies a RPI Beta 2 microglobulin B2M chain. #RPI-Chain true #RPI-Chain imgt_000134 #RPI-Chain #MolecularComponentLevelChainType #RPI-Chain RPI-Chain #RPI-Chain Identifies a related protein of the immune system (RPI) chain. #RPI-MH1Like-Alpha-Chain true #RPI-MH1Like-Alpha-Chain imgt_000177 #RPI-MH1Like-Alpha-Chain #ReceptorLevelChainType #RPI-MH1Like-Alpha-Chain RPI-MH1Like-Alpha-Chain #RPI-MH1Like-Alpha-Chain Identifies a RPI MH1Like Alpha chain. #RPI-PreB-Light-C-1-IGLL1-Chain imgt_000140 #RPI-PreB-Light-C-1-IGLL1-Chain #GeneLevelChainType #RPI-PreB-Light-C-1-IGLL1-Chain RPI-PreB-Light-C-1-IGLL1-Chain #RPI-PreB-Light-C-1-IGLL1-Chain Identifies a PreB receptor Light Constant-1 IGLL1 chain. #RPI-PreB-Light-C-2-IGLL2-Chain imgt_000299 #RPI-PreB-Light-C-2-IGLL2-Chain #GeneLevelChainType #RPI-PreB-Light-C-2-IGLL2-Chain RPI-PreB-Light-C-2-IGLL2-Chain #RPI-PreB-Light-C-2-IGLL2-Chain Identifies a PreB receptor Light Constant-2 IGLL2 chain. #RPI-PreB-Light-C-3-IGLL3-Chain imgt_000141 #RPI-PreB-Light-C-3-IGLL3-Chain #GeneLevelChainType #RPI-PreB-Light-C-3-IGLL3-Chain RPI-PreB-Light-C-3-IGLL3-Chain #RPI-PreB-Light-C-3-IGLL3-Chain Identifies a PreB receptor Light Constant-3 IGLL3 chain. #RPI-PreB-Light-C-4-IGLL4-Chain imgt_000298 #RPI-PreB-Light-C-4-IGLL4-Chain #GeneLevelChainType #RPI-PreB-Light-C-4-IGLL4-Chain RPI-PreB-Light-C-4-IGLL4-Chain #RPI-PreB-Light-C-4-IGLL4-Chain Identifies a PreB receptor Light Constant-4 IGLL4 chain. #RPI-PreB-Light-C-5-IGLL5-Chain imgt_000142 #RPI-PreB-Light-C-5-IGLL5-Chain #GeneLevelChainType #RPI-PreB-Light-C-5-IGLL5-Chain RPI-PreB-Light-C-5-IGLL5-Chain #RPI-PreB-Light-C-5-IGLL5-Chain Identifies a PreB receptor Light Constant-5 IGLL5 chain. #RPI-PreB-Light-C-Chain true #RPI-PreB-Light-C-Chain imgt_000181 #RPI-PreB-Light-C-Chain #ReceptorLevelChainType #RPI-PreB-Light-C-Chain RPI-PreB-Light-C-Chain #RPI-PreB-Light-C-Chain Identifies a RPI PreB receptor Light Constant chain. #RPI-PreB-Light-V-1-VPREB1-Chain imgt_000143 #RPI-PreB-Light-V-1-VPREB1-Chain #GeneLevelChainType #RPI-PreB-Light-V-1-VPREB1-Chain RPI-PreB-Light-V-1-VPREB1-Chain #RPI-PreB-Light-V-1-VPREB1-Chain Identifies a PreB receptor Light Variable-1 VPREB1 chain. #RPI-PreB-Light-V-2-VPREB2-Chain imgt_000144 #RPI-PreB-Light-V-2-VPREB2-Chain #GeneLevelChainType #RPI-PreB-Light-V-2-VPREB2-Chain RPI-PreB-Light-V-2-VPREB2-Chain #RPI-PreB-Light-V-2-VPREB2-Chain Identifies a PreB receptor Light Variable-2 VPREB2 chain. #RPI-PreB-Light-V-Chain true #RPI-PreB-Light-V-Chain imgt_000182 #RPI-PreB-Light-V-Chain #ReceptorLevelChainType #RPI-PreB-Light-V-Chain RPI-PreB-Light-V-Chain #RPI-PreB-Light-V-Chain Identifies a RPI PreB receptor Light Variable chain. #RPI-PreT-Alpha-Chain imgt_000183 #RPI-PreT-Alpha-Chain #ReceptorLevelChainType #RPI-PreT-Alpha-Chain RPI-PreT-Alpha-Chain #RPI-PreT-Alpha-Chain Identifies a RPI PreT receptor Alpha chain. #RPI-PreT-Alpha-PTCRA-Chain imgt_000145 #RPI-PreT-Alpha-PTCRA-Chain #GeneLevelChainType #RPI-PreT-Alpha-PTCRA-Chain RPI-PreT-Alpha-PTCRA-Chain #RPI-PreT-Alpha-PTCRA-Chain Identifies a PreT receptor Alpha PTCRA chain. #ReceptorLevelChainType true #ReceptorLevelChainType imgt_000173 #ReceptorLevelChainType ReceptorLevelChainType #ReceptorLevelChainType Identifies a chain type at the receptor level. #Species true #Species imgt_000103 #Species Species #Species Allows to identify a species. #Strain true #Strain imgt_000104 #Strain Strain #Strain Allows to identify an interbred variant group inside a subspecies or species, for laboratory or wild animals. #StructureType true #StructureType imgt_000081 #StructureType StructureType #StructureType The "StructureType" concept allows to identify the type of structure of EntityType leafconcepts. #Subspecies true #Subspecies imgt_000105 #Subspecies Subspecies #Subspecies Allows to identify a subspecies. #TR-Alpha-TRA-Chain true #TR-Alpha-TRA-Chain imgt_000184 #TR-Alpha-TRA-Chain #ReceptorLevelChainType #TR-Alpha-TRA-Chain TR-Alpha-TRA-Chain #TR-Alpha-TRA-Chain Identifies a T cell Receptor Alpha TRA chain. #TR-Alpha-TRAC-Chain imgt_0001406 #TR-Alpha-TRAC-Chain #GeneLevelChainType #TR-Alpha-TRAC-Chain TR-Alpha-TRAC-Chain #TR-Alpha-TRAC-Chain Identifies a T cell Receptor Alpha TRAC chain. #TR-Beta-1-TRBC1-Chain imgt_000147 #TR-Beta-1-TRBC1-Chain #GeneLevelChainType #TR-Beta-1-TRBC1-Chain TR-Beta-1-TRBC1-Chain #TR-Beta-1-TRBC1-Chain Identifies a T cell Receptor Beta-1 TRBC1 chain. #TR-Beta-2-TRBC2-Chain imgt_000148 #TR-Beta-2-TRBC2-Chain #GeneLevelChainType #TR-Beta-2-TRBC2-Chain TR-Beta-2-TRBC2-Chain #TR-Beta-2-TRBC2-Chain Identifies a T cell Receptor Beta-2 TRBC2 chain. #TR-Beta-TRB-Chain true #TR-Beta-TRB-Chain imgt_000185 #TR-Beta-TRB-Chain #ReceptorLevelChainType #TR-Beta-TRB-Chain TR-Beta-TRB-Chain #TR-Beta-TRB-Chain Identifies a T cell Receptor Beta TRB chain. #TR-Chain true #TR-Chain imgt_000191 #TR-Chain #MolecularComponentLevelChainType #TR-Chain TR-Chain #TR-Chain Identifies a T cell receptor (TR) chain. #TR-Delta-TRD-Chain true #TR-Delta-TRD-Chain imgt_000186 #TR-Delta-TRD-Chain #ReceptorLevelChainType #TR-Delta-TRD-Chain TR-Delta-TRD-Chain #TR-Delta-TRD-Chain Identifies a T cell Receptor Delta TRD chain. #TR-Delta-TRDC-Chain imgt_000149 #TR-Delta-TRDC-Chain #GeneLevelChainType #TR-Delta-TRDC-Chain TR-Delta-TRDC-Chain #TR-Delta-TRDC-Chain Identifies a T cell Receptor Delta TRDC chain. #TR-Gamma-1-TRGC1-Chain imgt_000150 #TR-Gamma-1-TRGC1-Chain #GeneLevelChainType #TR-Gamma-1-TRGC1-Chain TR-Gamma-1-TRGC1-Chain #TR-Gamma-1-TRGC1-Chain Identifies a T cell Receptor Gamma-1 TRGC1 chain. #TR-Gamma-2-TRGC2-Chain imgt_000151 #TR-Gamma-2-TRGC2-Chain #GeneLevelChainType #TR-Gamma-2-TRGC2-Chain TR-Gamma-2-TRGC2-Chain #TR-Gamma-2-TRGC2-Chain Identifies a T cell Receptor Gamma-2 TRGC2 chain. #TR-Gamma-3-TRGC3-Chain imgt_000152 #TR-Gamma-3-TRGC3-Chain #GeneLevelChainType #TR-Gamma-3-TRGC3-Chain TR-Gamma-3-TRGC3-Chain #TR-Gamma-3-TRGC3-Chain Identifies a T cell Receptor Gamma-3 TRGC3 chain. #TR-Gamma-4-TRGC4-Chain imgt_000153 #TR-Gamma-4-TRGC4-Chain #GeneLevelChainType #TR-Gamma-4-TRGC4-Chain TR-Gamma-4-TRGC4-Chain #TR-Gamma-4-TRGC4-Chain Identifies a T cell Receptor Gamma-4 TRGC4 chain. #TR-Gamma-5-TRGC5-Chain imgt_000154 #TR-Gamma-5-TRGC5-Chain #GeneLevelChainType #TR-Gamma-5-TRGC5-Chain TR-Gamma-5-TRGC5-Chain #TR-Gamma-5-TRGC5-Chain Identifies a T cell Receptor Gamma-5 TRGC5 chain. #TR-Gamma-TRG-Chain true #TR-Gamma-TRG-Chain imgt_000187 #TR-Gamma-TRG-Chain #ReceptorLevelChainType #TR-Gamma-TRG-Chain TR-Gamma-TRG-Chain #TR-Gamma-TRG-Chain Identifies a T cell Receptor Gamma TRG chain. #T_cell_receptor imgt_000067 #T_cell_receptor T_cell_receptor #T_cell_receptor TR #T_cell_receptor T cell receptors are proteins on the surface membrane of T lymphocytes, capable of specific recognition and binding with a peptide (or "processed antigen") associated with a major histocompatibility (MH) (human leucocyte antigen (HLA) in human) protein. #TaxonRank true #TaxonRank imgt_000100 #TaxonRank The "TaxonRank" concept allows to identify the type of taxon in which an object, process or relation is found. The "TaxonRank" concept manages a hierarchy of concepts at various levels of granularity. The corresponding hierarchical taxonomy is that provided by the National Center for Biotechnology Information NCBI (http://www.ncbi.nlm.nih.gov) up to the rank of species and subspecies ("Species" and "Subspecies" concepts, respectively) in order to establish complete interoperability with generalist databases. Since genes of the immunoglobulins (or antibodies) (IG), T cell receptors (TR) and major histocompatibility complex (MH) are only present in jawed vertebrates (gnathostoma), only vertebrate species were originally represented in IMGT-ONTOLOGY. However, with the extension of IMGT-ONTOLOGY to the immunoglobulin superfamily (IgSF) and MH superfamily (MhSF), invertebrate species are incorporated whenever necessary. The "EthnicGroup", "Breed" and "Strain" concepts have been added to IMGT-ONTOLOGY to allow the identification of data specific to ethnic groups for humans (http://www.ebi.ac.uk/imgt/hla/help/ethnic_help.html), breeds for domestic animals or strains for laboratory and wild animals. #TaxonRank TaxonRank #TaxonRank The "TaxonRank" concept allows to identify the type of taxon in which an object, process or relation is found. #TaxonomyRelated_StructureType true #TaxonomyRelated_StructureType imgt_000303 #TaxonomyRelated_StructureType TaxonomyRelated_StructureType #TaxonomyRelated_StructureType The "TaxonomyRelated_StructureType" concept allows to identify, whatever the molecule type (gDNA, cDNA, mRNA or protein), the structure of Molecule_EntityType leafconcepts resulting from more than one taxonomic sources. #V-D-J-C-chain true #V-D-J-C-chain imgt_000040 #V-D-J-C-chain V-D-J-C-chain #V-D-J-C-chain Identifies, for protein, molecule entities without a leader L region (mature form) and with a rearranged V region, at least one rearranged D, a rearranged J region and a C region in undefined configuration. V-D-J-C-chain is in rearranged configuration. #V-D-J-gene true #V-D-J-gene imgt_000041 #V-D-J-gene #V-D-J-gene V-D-J-gene #V-D-J-gene Identifies, for gDNA, molecule entities with a rearranged V gene, at least one rearranged D gene and a rearranged J gene. V-D-J-gene is in rearranged configuration. #V-D-gene true #V-D-gene imgt_000039 #V-D-gene V-D-gene #V-D-gene Identifies, for gDNA, molecule entities with a rearranged V gene and a partially_rearranged D gene. V-D-gene is in partially_rearranged configuration. #V-J-C-chain true #V-J-C-chain imgt_000043 #V-J-C-chain V-J-C-chain #V-J-C-chain Identifies, for protein, molecule entities without a leader L region (mature form) and with a rearranged V region, a rearranged J region and a C region in undefined configuration. V-J-C-chain is in rearranged configuration. #V-J-gene true #V-J-gene imgt_000044 #V-J-gene V-J-gene #V-J-gene Identifies, for gDNA, molecule entities with a rearranged V gene and a rearranged J gene. V-J-gene is in rearranged configuration. #V-gene true #V-gene imgt_000042 #V-gene V-gene #V-gene Identifies, for gDNA, molecule entities with a germline V gene. V-gene is in germline configuration. #_for_ imgt_000106 #_for_ _for_ #_for_ Domain concept is a property for range concept. #_has_ imgt_000107 #_has_ _has_ #_has_ Domain concept has property in range concept. #alternative_splicing imgt_000083 #alternative_splicing alternative_splicing #alternative_splicing Identifies the structure of "Molecule_EntityType" gene leafconcepts that have characteristics for potential alternative splicing (for example, IG genes with features for potential secreted and membrane chains). #cDNA true #cDNA imgt_000070 #cDNA cDNA #cDNA Identifies complementary DNA, a nucleotide sequence made of A, T, C, G, obtained in vitro by reverse transcription of mRNA. #cDNA_sequence imgt_000075 #cDNA_sequence cDNA_sequence #cDNA_sequence Identifies a cDNA sequence unit. #chain imgt_000076 #chain chain #chain Identifies an amino acid sequence unit. #chimeric imgt_000084 #chimeric For example, L-V-D-J-C-sequence of IG resulting from the fusion in vitro of the variable domain from one source (synthetic, murine, rat, …) with the constant region from human [2 sources]. #chimeric chimeric #chimeric Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that have a classical organization and result from the fusion in vivo or in vitro of molecules from two (usually) sources. #composite_protein_for_clinical_applications imgt_000260 #composite_protein_for_clinical_applications CPCA do not have a special suffix (stem) in INN but are designated by a name related to their mode of action (MOA) or biological property. #composite_protein_for_clinical_applications composite_protein_for_clinical_applications #composite_protein_for_clinical_applications CPCA #composite_protein_for_clinical_applications Identifies genetically engineered proteins other than FPIA that result from the fusion of peptide, region and/or domain of protein(s) of different sources, or from the fusion of peptide, region and/or domain of protein(s) to a chemical or biochemical agent. The Fc may be present and used as a transporter or to increase the product half-life but, not for its effector properties that are rather avoided. #constant true #constant imgt_000053 #constant constant #constant Identifies a constant (C) gene, a gene that codes the constant region of an IG or of a TR chain. #conventional true #conventional imgt_000054 #conventional A conventional gene has by definition the characteristics of a classical gene (initiation codon and stop codon in the same gene unit). #conventional conventional #conventional Identifies any (coding or not coding) gene other than IG or TR genes. #conventional-gene true #conventional-gene imgt_000013 #conventional-gene conventional-gene #conventional-gene Identifies, for gDNA, molecule entities with a conventional gene in undefined configuration. conventional-gene is in undefined configuration. #conventional_with_leader true #conventional_with_leader imgt_000112 #conventional_with_leader conventional_with_leader #conventional_with_leader Identifies any (coding or not coding) gene other than IG or TR genes with a leader L region (or signal peptide). #conventional_without_leader true #conventional_without_leader imgt_000113 #conventional_without_leader conventional_without_leader #conventional_without_leader Identifies any (coding or not coding) gene other than IG or TR genes with no leader L region (or signal peptide). #defines imgt_000108 #defines defines #defines Domain concept defines range concept. #diabody imgt_000280 #diabody diabody #diabody Identifies an engineered bivalent IG (or antibody) format made of two VH+VL chains, noncovalently linked head to foot. The domains of the same chain are connected by a too short linker to allow their own pairing. #diversity true #diversity imgt_000055 #diversity diversity #diversity Identifies a diversity (D) gene, a gene that rearranges at the DNA level and codes the diversity region of the variable domain of an IG or of a TR chain. #engineered imgt_000085 #engineered engineered #engineered Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that have been modified by deliberate mutagenesis in vitro [1 source]. #functional true #functional imgt_000047 #functional functional #functional Identifies, whatever the molecule type, the functionality of Molecule_EntityType leafconcepts in undefined or germline configuration, whose coding region has an open reading frame without stop codon, and if there is no described defect in the splicing sites, recombination signals and/or regulatory elements. #fusion imgt_000086 #fusion fusion #fusion Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that do not have a classical organization and result from the fusion in vivo or in vitro of molecules from two (or more) different sources [2 (or more) sources]. #fusion_protein_for_immune_applications imgt_000261 #fusion_protein_for_immune_applications FPIA are currently designated with the suffix (stem) '-cept' in INN. #fusion_protein_for_immune_applications fusion_protein_for_immune_applications #fusion_protein_for_immune_applications FPIA #fusion_protein_for_immune_applications Identifies proteins that result generally from the fusion of one or several region and/or domain of protein(s) with the Fc of an IG in a '(protein)2:Fc' format. The Fc is used for its effector properties. #gDNA true #gDNA imgt_000071 #gDNA gDNA #gDNA Identifies genomic DNA, a nucleotide sequence made of A, T, C, G, obtained from a genome, or by extension, synthetic DNA having the characteristics of genomic DNA. #gene imgt_000077 #gene This definition includes the coding region or 'region', the regulatory elements in 5' and 3', and the introns, if present. #gene gene #gene Identifies a gDNA sequence unit that can be potentially transcribed and/or translated. #germline true #germline imgt_000003 #germline germline #germline Identifies, whatever the molecule type, the configuration of the IG and TR variable (V), diversity (D) and joining (J) genes before DNA rearrangements, and by extension, the configuration of the Molecule_EntityType leafconcepts that contain germline genes (with or without constant (C) genes in undefined configuration). #hasChainTypeLevel imgt_000267 #hasChainTypeLevel hasChainTypeLevel #hasChainTypeLevel allows to set the Level of granularity of a concept of ChainType. #humanized imgt_000087 #humanized For example, L-V-D-J-C-sequence of IG resulting from the grafting in vitro of the complementarity determining region (CDR) from one source (murine, rat...) to the framework regions (FR) (and with the constant region) from human [2 sources]. #humanized humanized #humanized Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that have a classical organization and have been modified in vitro with the purpose of humanization. By extension, the variable domain is also identified as humanized. #immature_form true #immature_form imgt_000088 #immature_form immature_form #immature_form Identifies the structure of "Molecule_EntityType" chain leafconcepts which are chains with a leader L region (or signal peptide). #immunoglobulin true #immunoglobulin imgt_000065 #immunoglobulin An antibody or immunoglobulin monomer is formed by two identical light chains and two identical heavy chains. There are five classes of immunoglobulins in human, IgM, IgD, IgG, IgA and IgE, each with distinct heavy chains (mu, delta, gamma, alpha and epsilon, respectively). When expressed at the surface of the B cells, immunoglobulins are anchored by their heavy chains. These membrane immunoglobulins (mIgM, mIgD, mIgG, mIgA and mIgE) are associated with CD79A (Ig-alpha, mb-1) and CD79B (Igbeta, B29). One CD79A-CD79B heterodimer and one immunoglobulin monomer constitute the B cell receptor (BcR). When secreted by the plasmocytes, immunoglobulins are monomeric (IgG, IgD, IgE, and IgA in serum), dimeric (IgA in seromucous secretions), or pentameric (IgM). #immunoglobulin immunoglobulin #immunoglobulin IG #immunoglobulin Immunoglobulins (or antibodies) are proteins capable of specific recognition and binding with an antigen. Antibodies carries antigen-binding sites that bind non-covalently with the corresponding antigen epitope. Antibodies are produced in the body by the B lymphocytes at the cell surface and are secreted by plasma cells, in response to stimulation by antigen. #immunotoxin imgt_000300 #immunotoxin immunotoxin #immunotoxin Identifies an IG (or antibody) or RPI protein conjugated to a toxin, obtained in vitro. #interleukin imgt_000295 #interleukin interleukin #interleukin IL #interleukin Identifies interleukins (IL) or cytokines secreted by leukocytes and endothelial cells that bind to interleukin receptor on T, B and hematopoietic cells. This interaction leads to signalling that promotes cell development and differentiation. #is_defined_by imgt_000109 #is_defined_by is_defined_by #is_defined_by Domain concept is defined by range concept. #joining true #joining imgt_000056 #joining joining #joining Identifies a joining (J) gene, a gene that rearranges at the DNA level and codes the joining region of the variable domain of an IG or of a TR chain. #linker imgt_000301 #linker linker #linker Identifies a short sequence used to link two other sequences. #mRNA true #mRNA imgt_000072 #mRNA mRNA #mRNA Identifies messenger RNA, a nucleotide sequence made of A, U, C, G, obtained by transcription of gDNA. #major_histocompatibility imgt_000066 #major_histocompatibility The peptides are non-covalently bound in a groove formed by two G (groove) domains. The two domains belong to the same chain (alpha chain of the MH class I or MH1), or to two different chains (alpha and beta chains of the MH class II or MH2). In the MH1, the alpha chain is associated to the beta2-microglobulin (B2M). #major_histocompatibility major_histocompatibility #major_histocompatibility MH #major_histocompatibility Identifies major_histocompatibility (MH) proteins capable of presenting peptides (or "processed antigen") to the T lymphocytes. #mature_form true #mature_form imgt_000089 #mature_form mature_form #mature_form Identifies the structure of "Molecule_EntityType" leafconcepts which are chains without a leader L region (or signal peptide). #membrane imgt_000090 #membrane membrane #membrane Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that have a transmembrane exon or region allowing for a transmembrane chain. #nt-sequence true #nt-sequence imgt_000037 #nt-sequence nt-sequence #nt-sequence Identifies, for cDNA, molecule entities with a conventional region in undefined configuration. nt-sequence is in undefined configuration. #nt-transcript true #nt-transcript imgt_000038 #nt-transcript nt-transcript #nt-transcript Identifies, for mRNA, molecule entities with a conventional region in undefined configuration. nt-transcript is in undefined configuration. #nucleic_acid true #nucleic_acid imgt_000069 #nucleic_acid nucleic_acid #nucleic_acid Identifies a sequence made of nucleotides (A, U or T, C, G). #oligonucleotide imgt_000078 #oligonucleotide Usually designed in vitro, they are designated as primer, if used in polymerase chain reaction (PCR) amplification or for sequencing. #oligonucleotide oligonucleotide #oligonucleotide Identifies a short nucleic acid sequence unit . #orphon true #orphon imgt_000060 #orphon orphon #orphon Identifies, whatever the molecule type, a gene that is found in vivo on a different locus from the main locus (either on the same chromosome or on another chromosome). #partially_processed imgt_000091 #partially_processed partially_processed #partially_processed Identifies the structure of "Molecular_EntityType" leafconcepts which are genes (usually orphons) that have lost part of their introns. #partially_rearranged true #partially_rearranged imgt_000004 #partially_rearranged partially_rearranged #partially_rearranged Identifies, whatever the molecule type, the configuration of partially_rearranged IG or TR diversity (D) genes, and by extension, the configuration of Molecule_EntityType leafconcepts that contain at least one partially_rearranged D gene [with another D or with rearranged variable (V) or joining (J) genes (with or without constant (C) genes in undefined configuration)]. #partially_spliced imgt_000092 #partially_spliced partially_spliced #partially_spliced Identifies the structure of "Molecular_EntityType" leafconcepts which are transcripts or cDNA sequences that have been submitted to partial RNA processing or splicing. #peptide imgt_000079 #peptide peptide #peptide Identifies a short amino acid sequence unit (made of a small number of amino acids) #polymeric_immunoglobulin_receptor imgt_000296 #polymeric_immunoglobulin_receptor polymeric_immunoglobulin_receptor #polymeric_immunoglobulin_receptor PIGR #polymeric_immunoglobulin_receptor Identifies a polymeric immunoglobulin (IgA and IgM) receptor. #processed imgt_000093 #processed processed #processed Identifies the structure of "Molecule_EntityType" leafconcepts which are genes (usually orphons) that have lost their introns. #productive true #productive imgt_000049 #productive productive #productive Identifies, whatever the molecule type, the functionality of Molecule_EntityType leafconcepts in rearranged or partially_rearranged configuration, whose coding region has an open reading frame without stop codon, if for IG and TR there is an in-frame junction, and if there is no described defect in the initiation codon, splicing sites and/or regulatory elements. #protein true #protein imgt_000073 #protein protein #protein Identifies a sequence made of amino acids, obtained by translation of mRNA, or by in vitro synthesis. #pseudogene true #pseudogene imgt_000050 #pseudogene pseudogene #pseudogene Identifies, whatever the molecule type, the functionality of Molecule_EntityType leafconcepts in undefined or germline configuration, whose coding region has stop codon(s) and/or frameshift mutation(s), and/or if, for a conventional or a leafconcepts that contain V gene, a mutation affects the initiation codon. #rearranged true #rearranged imgt_000005 #rearranged rearranged #rearranged Identifies, whatever the molecule type, the configuration of the IG and TR variable (V), diversity (D) and joining (J) genes after DNA rearrangements, and by extension, the configuration of the Molecule_EntityType leafconcepts that contain rearranged genes with, if present, completely rearranged D genes (with or without constant (C) genes in undefined configuration). #regular imgt_000094 #regular regular #regular Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that have a classical organization without in vivo or in vitro modification. #related_protein_of_immune_system imgt_000262 #related_protein_of_immune_system related_protein_of_immune_system #related_protein_of_immune_system RPI #related_protein_of_immune_system Identifies proteins of the immunoglobulin superfamily (IgSF) other than IG and TR, the proteins of the major histocompatibility superfamily (MhSF) other than MH, cytokines and their receptors, integrins, proteins of the scavenger receptor superfamily (SrSF) and any protein found in vivo that is, directly or indirectly, involved in the immune response. #scFv imgt_000281 #scFv scFv #scFv Identifies a single chain Fv. A scFV is an engineered monovalent IG (or antibody) or TR made of two V domains (usually one VH and one VL domain (VH+VL)), covalently linked by a linker whose length allows the pairing of the domains. #secreted imgt_000095 #secreted secreted #secreted Identifies, whatever the molecule type, the structure of "Molecule_EntityType" leafconcepts that have an hydrophilic C-terminal exon or region allowing for a secreted soluble chain. #spliced imgt_000096 #spliced spliced #spliced Identifies the structure of "Molecular_EntityType" leafconcepts which are transcripts or cDNA sequences that have been submitted to complete RNA processing or splicing. #sterile_transcript imgt_000097 #sterile_transcript For example, for IG or TR, transcripts of V, D or J genes in germline configuration (also designated as 'germline transcripts'), transcripts of C genes in undefined configuration, transcripts of switch regions, and corresponding cDNA, respectively. #sterile_transcript sterile_transcript #sterile_transcript Identifies the structure of "Molecular_EntityType" leafconcepts which are transcripts that cannot be translated in vivo, and corresponding cDNA. #transcript imgt_000080 #transcript transcript #transcript Identifies a mRNA sequence unit that is transcribed from gDNA and that can be potentially translated. #transgene true #transgene imgt_000061 #transgene transgene #transgene Identifies, whatever the molecule type, a gene that is artificially introduced into a multicellular organism (mouse, plant...). #translocated true #translocated imgt_000062 #translocated translocated #translocated Identifies, whatever the molecule type, a gene that results from a translocation (in vivo). #transposed true #transposed imgt_000063 #transposed transposed #transposed Identifies, whatever the molecule type, a transgene or a retrotransposon that is permanently inserted in a chromosome. #truncated imgt_000302 #truncated truncated #truncated Identifies a shortened protein (missing amino acids) owing to a premature STOP-CODON. #undefined true #undefined imgt_000006 #undefined undefined #undefined Identifies, whatever the molecule type, the configuration of the conventional genes and that of the IG and TR constant (C) genes, and by extension, the configuration of the Molecule_EntityType leafconcepts that only contain genes in undefined configuration. #unprocessed imgt_000098 #unprocessed unprocessed #unprocessed Identifies the structure of "Molecule_EntityType" leafconcepts which are genes (usually orphons) that have all their introns. #unproductive true #unproductive imgt_000051 #unproductive unproductive #unproductive Identifies, whatever the molecule type, the functionality of Molecule_EntityType leafconcepts in rearranged or partially_rearranged configuration, whose coding region has stop codon(s) and/or frameshift mutation(s), and/or for IG and TR an out-of-frame junction, and/or if a mutation affects the initiation codon, and/or if there are defects in the splicing sites and/or in the regulatory element(s), and/or there are unusual features (translocated, gene fusion...) and/or changes of conserved amino acids demonstrated as leading to uncorrect folding. #unspliced imgt_000099 #unspliced unspliced #unspliced Identifies the structure of Molecular_EntityType" leafconcepts which are transcripts or cDNA sequences that have not been submitted to RNA processing or splicing. #variable true #variable imgt_000057 #variable variable #variable Identifies a variable (V) gene, a gene that rearranges at the DNA level and codes the variable region of the variable domain of an IG or of a TR chain. #variable_lymphocyte_receptor imgt_000297 #variable_lymphocyte_receptor variable_lymphocyte_receptor #variable_lymphocyte_receptor VLR #variable_lymphocyte_receptor Identifies a variable lymphocyte receptor (VLR) in Petromyzon marinus (lamprey).