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INN (International Nonproprietary Name)
-
any
none
abagovomab
abatacept
abciximab
adalimumab
adecatumumab
afelimomab
aflibercept
afutuzumab
alacizumab pegol
alefacept
alemtuzumab
altumomab
alvircept sudotox
anatumomab mafenatox
anrukinzumab
apolizumab
arcitumomab
aselizumab
atacicept
atorolimumab
baminercept
bapineuzumab
basiliximab
bavituximab
bectumomab
belatacept
belimumab
benralizumab
bertilimumab
besilesomab
bevacizumab
biciromab
bifarcept
bivatuzumab
blinatumomab
brentuximab vedotin
briakinumab
briobacept
canakinumab
cantuzumab mertansine
capromab
catumaxomab
cedelizumab
certolizumab pegol
cetuximab
citatuzumab bogatox
cixutumumab
clenoliximab
conatumumab
dacetuzumab
daclizumab
dalotuzumab
daratumumab
denosumab
detumomab
dorlimomab aritox
ecromeximab
eculizumab
edobacomab
edrecolomab
efalizumab
efungumab
elotuzumab
elsilimomab
enlimomab
enlimomab pegol
epitumomab
epitumomab cituxetan
epratuzumab
erlizumab
ertumaxomab
etanercept
etaracizumab
exbivirumab
faralimomab
farletuzumab
felvizumab
fezakinumab
figitumumab
fontolizumab
foravirumab
fresolimumab
galiximab
gantenerumab
gavilimomab
gemtuzumab
girentuximab
glembatumumab
golimumab
ibalizumab
ibritumomab tiuxetan
igovomab
imciromab
infliximab
inolimomab
inotuzumab ozogamicin
intetumumab
iodine (124I) girentuximab
ipilimumab
iratumumab
keliximab
labetuzumab
lebrikizumab
lemalesomab
lenercept
lerdelimumab
lexatumumab
libivirumab
lintuzumab
lucatumumab
lumiliximab
mapatumumab
maslirnomab
matuzumab
mavrilimumab
mepolizumab
metelimumab
milatuzumab
minretumomab
mirococept
mitumomab
morolimumab
motavizumab
moxetumomab pasudotox
muromonab-CD3
nacolomab tafenatox
naptumomab estafenatox
natalizumab
nebacumab
necitumumab
nerelimomab
nimotuzumab
ocrelizumab
odulimomab
ofatumumab
omalizumab
onercept
oportuzumab monatox
oregovomab
otelixizumab
pagibaximab
palivizumab
panitumumab
panobacumab
pascolizumab
pegsunercept
pertuzumab
pexelizumab
priliximab
pritumumab
racotumomab
rafivirumab
ramucirumab
ranibizumab
raxibacumab
regavirumab
reslizumab
rilonacept
rilotumumab
rituximab
robatumumab
rontalizumab
rovelizumab
ruplizumab
satumomab
secukinumab
sevirumab
sibrotuzumab
sifalimumab
siltuximab
siplizumab
solanezumab
sontuzumab
sotatercept
stamulumab
sulesomab
suvizumab
tadocizumab
talizumab
tanezumab
taplitumomab paptox
technetium (99mTc) fanolesomab
technetium (99mTc) nofetumomab merpentan
technetium (99mTc) pintumomab
tefibazumab
telimomab aritox
tenatumomab
teneliximab
teplizumab
teprotumumab
tigatuzumab
tocilizumab
toralizumab
tositumomab
tovangitide
tralokinumab
trastuzumab
tremelimumab
tucotuzumab celmoleukin
tuvirumab
urtoxazumab
ustekinumab
vapaliximab
vedolizumab
veltuzumab
vepalimomab
visilizumab
volociximab
votumumab
yttrium (90Y) tacatuzumab tetraxetan
Yttrium (Y 90) clivatuzumab tetraxetan
zalutumumab
zanolimumab
ziralimumab
zolimomab aritox
INN proposed list
-
any
none
L59 (1988)
L66 (1991)
L68 (1992)
L69 (1993)
L70 (1993)
L71 (1994)
L72 (1994)
L73 (1995)
L74 (1995)
L75 (1996)
L76 (1996)
L77 (1997)
L78 (1997)
L79 (1998)
L80 (1998)
L81 (1999)
L82 (1999)
L83 (2000)
L84 (2000)
L85 (2001)
L86 (2002)
L87 (2002)
L88 (2003)
L89 (2003)
L90 (2004)
L91 (2004)
L92 (2004)
L93 (2005)
L94 (2005)
L95 (2006)
L96 (2006)
L97 (2007)
L98 (2007)
L99 (2008)
L100 (2008)
L101 (2009)
L102 (2009)
and before
and after
INN number
-
any
none
6281
6345
6516
6559
6560
6605
6614
6658
6867
6964
6977
7042
7046
7055
7056
7105
7156
7164
7165
7200
7201
7227
7250
7253
7263
7310
7340
7364
7417
7433
7471
7496
7513
7514
7519
7525
7542
7546
7560
7567
7578
7580
7602
7609
7615
7623
7636
7637
7646
7647
7655
7716
7753
7757
7783
7821
7827
7833
7860
7866
7869
7873
7876
7882
7906
7920
7934
7965
8005
8014
8017
8024
8039
8046
8047
8054
8059
8060
8061
8076
8087
8103
8106
8109
8122
8127
8132
8150
8153
8183
8207
8210
8211
8223
8227
8231
8232
8239
8241
8251
8264
8276
8291
8298
8313
8332
8339
8370
8371
8372
8380
8381
8394
8406
8407
8412
8438
8443
8448
8449
8451
8481
8484
8495
8497
8499
8500
8536
8545
8568
8574
8580
8598
8600
8605
8606
8624
8627
8635
8636
8643
8651
8652
8653
8658
8659
8669
8683
8693
8713
8716
8734
8739
8750
8753
8818
8832
8836
8862
8864
8869
8887
8888
8894
8922
8932
8941
8942
8944
8954
8959
8963
8976
8979
8998
9028
9029
9043
9045
9046
9051
9052
9053
9067
9074
9083
9085
9092
9093
9097
9098
9099
9107
9114
9116
9117
9123
9128
9134
9135
9137
9144
9153
9158
9165
9182
9185
9188
9199
9200
9226
9233
9234
9235
9236
INN recommended list
-
any
none
R29 (1989)
R32 (1992)
R33 (1993)
R34 (1994)
R35 (1995)
R36 (1996)
R37 (1997)
R38 (1997)
R39 (1998)
R40 (1998)
R41 (1999)
R42 (1999)
R43 (2000)
R44 (2000)
R45 (2001)
R46 (2001)
R47 (2002)
R48 (2002)
R49 (2003)
R50 (2003)
R51 (2004)
R52 (2004)
R53 (2005)
R54 (2005)
R55 (2006)
R56 (2006)
R57 (2007)
R58 (2007)
R59 (2008)
R60 (2008)
R61 (2009)
R62 (2009)
and before
and after
IMGT/mAb-DB section
-
any
none
Bispecific
Chimeric
Chimeric (Light Chain)
Human
Humanized
Humanized (Heavy Chain)
Hybrid
Immunoadhesin
Immunotoxin
Murine
Rat
Radiolabelled/ Conjugated
-
any
none
conjugated wih chelator DTPA
conjugated wih tetraextan
conjugated with Bougainvillea spectabilis Willd bouganin
conjugated with calicheamicin
conjugated with chelator
conjugated with doxorubicin
conjugated with MMAE (ADC)
conjugated with Phytolacca americana (pokeweed) antiviral protein PAP
conjugated with Pseudomonas aeruginosa exotoxin A
conjugated with ricin A
conjugated with Staphyloccocus aureus enterotoxin A
radiolabelled with Indium-111, In-111
radiolabelled with iodine (124I)
radiolabelled with Iodine-131, I-131
radiolabelled with Lutetium-177, Lu-177
radiolabelled with Technetium (99m Tc)
radiolabelled with Yttrium-90, Y-90
Common name
Entries with 2Dstructure
-
any
none
7164
7602
7609
7637
7783
7906
8005
8017
8039
8122
8313
8380
8598
8651
8658
8659
8669
8693
8734
8739
8750
8753
8818
8832
8836
8862
8864
8869
8887
8888
8894
8922
8932
8941
8942
8944
8954
8959
8963
8976
8979
8998
9028
9029
9043
9045
9046
9051
9052
9053
9067
9074
9083
9085
9092
9093
9097
9098
9099
9107
9114
9116
9117
9123
9128
9134
9135
9137
9153
9158
9165
9182
9185
9188
9199
9200
9226
9233
9234
9235
9236
Proprietary name
-
any
none
ACTEMRA™
ALLOMUNE™
AMEVIVE®
ANTEGREN® (formerly)
ANTILFA®
Antova™
ARCALYST™
Arzerra™
AVASTIN®
AVICIDIN® conjuguate with streptavidin using Pretarget™ technology (biotin)
BEXXAR®
Bosatria®
CAMPATH®
CEA-SCAN™
CEACIDE™
CIMZIA®
CORSEVIN™ M
COTARA®
E5™
ENBREL®
ERBITUX®
HERCEPTIN®
HUMANEERED™
HuMax-CD4®
HuMaX-EGFR™
Humicade™
HUMIRA®
ILARIS®
LEUKARREST™
LEUKOSCAN®
LUCENTIS®
LYMPHOCIDE™
MABCAMPATH®
MABTHERA®
Mycograb®
MYLOTARG®
MYOSCINT®
NUMAX®
NUVION®
OMNITARG™
ONCOLTAD®
ONCOLYM®
ONCOSCINT® CR/OV
ORENCIA®
ORTHOCLONE OKT3®
OSTAVIR™
OVAREX®
PANOREX®
PRIMATIZED®
PROSTASCINT®
PROTOVIR™
PROXINIUM™
RAPTIVA®
REMICADE®
REMITOGEN™
Removab®
RENCAREX®
REOPRO®
Rexomun®
RITUXAN®
RoACTEMRA®
SIMPONI™
SIMULECT®
SMART™ 1D10
SMART™ anti-CD3
SMART™ M195
SOLIRIS™
STELARA™
STIMUMAB™
SYNAGIS®
THERACIM®
TRUDEXA®
TYSABRI®
VECTIBIX™
VERLUMA®
VICINIUM™
VITAXIN®
XOLAIR®
ZAMYL™
ZENAPAX®
ZEVALIN®
Entries with 3Dstructure
-
any
none
1bey
1bj1
1ce1
1cz8
1l6x
1l7i
1n8z
1s78
1yy8
1yy9
2osl
3eo9
3eoa
3eob
Isotype and format
OR
Fusion protein format
-
any
none
ACVR2A (activin receptor type 2a, activin receptor type IIA ) - IGHG1 Fc
CTLA4-IGHG1 Fc
Interleukin-1 receptor accessory protein (IL1RAP)-type 1 interleukin-1 receptor-IGHG1 Fc
Leucocyte function associated antigen 3 (LFA3)-IGHG1 Fc
mAb huBC1 - interleukin 12
mAb huKS - interleukin 2
TNFRSF13C (tumor necrosis factor receptor superfamily member 13C, BAFFR, BR3, B cell activating factor receptor, CD268)-IGHG1 Fc
Tumor necrosis factor receptor (TNFR) alpha - IGHG1 Fc
Tumor necrosis factor receptor superfamily member 13B, (TNFR13B, TACI (Transmembrane Activator and CAML Interactor), CD267)-IGHG1 Fc
Tumor necrosis factor receptor superfamily member 3 (TNFRSF3, lymphotoxin beta receptor, LTBR, TNFCR)-IGHG1 Fc
Vascular endothelial growth factor receptor 1, (VEGFR1, FLT1, TRT) - VEGFR2 (KDR, FLK1, CD309)-IGHG1 Fc
Origin clone species
-
any
none
Mus musculus (house mouse)
Homo sapiens (human)
Rattus norvegicus (Norway rat)
Rattus sp. (rats)
Macaca fascicularis (crab-eating macaque)
Origin clone name
Specificity (target)
-
any
none
4F2, CD98hc (CD98 heavy chain), FRP-1 (fusion regulatory protein 1)
ACVR2A (activin receptor type 2a, activin receptor type IIA )
ADP-ribosyl cyclase 1 (CD38, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10)
Alpha fetoprotein (α-fetoprotein)
Amyloid peptides Aβ42 and Aβ40
Amyloid-beta (Abeta) peptide soluble monomer
Beta amyloid (β-amyloid)
BSG (Basigin; CD147)
C5 (complement 5)
Carcinoma associated antigen
Cardiac myosin
CCL11 (Chemokine ligand 11; eotaxin1)
CD14
CD147
CD15
CD19 (B lymphocyte surface antigen B4; Leu-12)
CD2 (LFA-2, Lymphocyte function antigen 2)
CD22 (BL-CAM)
CD22 (sialic acid-binding Ig-like lectin2, Siglec-2, SIGLEC2, Leu14, B-lymphocyte cell adhesion molecule, BL-CAM)
CD3
CD33 (SIGLEC3; SIGLEC-3; gp67; p67)
CD38
CD3E (CD3 epsilon)
CD4 (p55)
CD40 (tumor necrosis factor receptor superfamily member 5; TNFRSF5)
CD40LG (CD40 ligand; CD40L; TNFSF5, tumor necrosis factor ligand superfamily member 5; TRAP, tumor necrosis factor related activation protein)
CD41/CD61, INTEGRIN-ALPHA-IIb_BETA-3, αIIbβ3, GPIIbIIIa, Fibrinogen receptor
CD52
CD54 (intercellular adhesion molecule 1; ICAM1)
CD74 (major histocompatibility complex class II invariant chain)
CD80, B7
CD86
CEACAM3, CGM1
CEACAM5 (carcinoembryonic antigen; CEA; CD66e)
CSF2RA (granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, CD116)
CTLA4
Digoxin
ED-B (extra domain B) of fibronectin
EGFR (Epidermal Growth Factor Receptor; ERBB1; HER1; ERBB)
Endotoxin C0246612
EPCAM (epithelial cell adhesion molecule; TACSTD1, Tumor-associated calcium signal transducer 1; GA733-2, gastrointestinal tumor-associated protein 2; EGP-2, epithelial glycoprotein 2; Ep-CAM, epithelial cell adhesion molecule; KSA; KS1/4 antigen; M4S; tumor antigen 17-1A; CD326; EpCAM)
Episialin
ERBB2 (Epidermal Growth Factor Receptor 2; HER-2; p185c-erbB2; NEU; EGFR2)
F glycoprotein (fusion protein)
Factor VII
FCER2 (Immunoglobulin E receptor type II; CD23)
FCGR1 (FCGR1A, FCGR1B, FCGR1C) (Fc gamma RI; CD64)
Fibrin
FOLR1 (folate receptor 1; FR-alpha, folate receptor alpha; FBP, adult folate-binding protein) ovarian tumor-associated antigen MOv18
G-28
GD2 ganglioside
GD3 idiotype
GDF-8 (growth differentiation factor 8)
GPNB (glycoprotein transmembrane NMB, hematopoeitic growth factor inducible neurokinin-1 type, HGFIN)
Hapten NP-cap (4-hydroxy-3-nitrophenacethyl caproic acid)
HBV (hepatitis B virus)
HCMV (human cytomegalovirus)
Heat shock protein 90 homolog from yeast
Hepatocyte growth factor (HGF, scatter factor, SF, hepatopoeitin A)
Herpesvirus 5 glyco-protein B
HIV (human immunodeficiency virus)
HIV-1 (human immunodeficiency virus)
HLA-DR10
HLA-DRB (HLA-DR beta)
HMW-MAA (High molecular weight-melanoma-associated antigen)
HSV (herpes simple virus)
ICAM3 (intercellular adhesion molecule 3; CD50; ICAM-3)
Idiotype
IFNA (IFN alpha; interferon alpha)
IFNG (interferon gamma; IFN gamma)
IgE
IGF1R (insulin-like growth factor 1 receptor; IGF-1R; IGF-1 receptor; CD221)
IGF1R (insulin-like growth factor 1 receptor; IGF-1R; CD221)
IL 22 (interleukin 22; IL-22)
IL1 (interleukin 1; IL-1)
IL12 (interleukin 12; IL-12)
IL12B (interleukin 12 beta; IL-12B; IL12 p40; CMLF p40; NKSF2)
IL13 (interleukin 13; IL-13)
Il15 (interleukin 15; IL-15)
IL15R (interleukin 15 receptor; IL-15R)
IL17A (interleukin 17A; IL-17A)
IL1B (interleukin 1 beta; IL-1B)
IL23 (interleukin 23; IL-23)
IL2R (interleukin 2 receptor; IL-2R; p55)
IL2R (interleukin 2 receptor; IL-2R; p56)
IL2RA (interleukin-2 receptor, alpha subunit; IL-2RA; TAC; CD25)
IL2RB (interleukin-2 receptor, beta; IL-2R; p70; CD122)
IL4 (interleukin 4; IL-4)
IL5 (interleukin 5; IL-5)
IL5RA (interleukin 5 receptor subunit alpha; CD125)
IL6 (interleukin 6; IL-6)
IL6R (interleukin 6 receptor; IL-6R)
IL8 (interleukin 8; IL-8)
IL9 (interleukin 9; IL-9)
INTEGRIN-ALPHA-4_BETA-1, α4β1, VLA4, VCAM1 receptor
INTEGRIN-ALPHA-4_BETA-7, α4β7, LPAM-1 (lymphocyte Peyer's patch adhesion molecule 1)
INTEGRIN-ALPHA-5_BETA-1, α5β1, VLA5, Fibronectin receptor
IRP-2 (Iron Regulatory Protein 2)
ITGAL (INTEGRIN-ALPHA-L; LFA-1, lymphocyte function associated antigen 1; CD11a)
ITGAV/ITGB3 (INTEGRIN-ALPHA-V_BETA-3; αvβ3; CD51/CD61; CD51/GPIIIa; CD51/platelet membrane glycoprotein IIIa; VNR, vitronectin receptor; AlphaVbeta3 integrin)
ITGB1 (INTEGRIN-BETA-1; CD29)
ITGB2 (INTEGRIN-BETA-2; CD18)
KDR (kinase insert domain receptor; VEGFR2, Vascular endothelial growth factor receptor 2; VEGF-R2; FLK1; CD309)
Lewis Y
lipoteichoic acid
LTBR (lymphotoxin beta receptor; TNFRSF3, tumor necrosis factor receptor superfamily member 3; TNFCR)-IGHG1 Fc
Lysozyme
MS4A1 (membrane-spanning 4-domains subfamily A member 1; CD20; B1, B lymphocyte surface antigen; Leu-16; Bp35)
MUC1 (mucin1; CD227; PEM, polymorphic epithelial mucin)
MUC16 (CA125, Homo sapiens cancer antigen 125; MUC-16; Mus musculus mAb OC125)Paratope of anti-
NCA 90 (10)
NCAM1 (neural cell adhesion molecule 1; CD56; NCAM-1)
NGF (nerve growth factor; NGFB, beta polypeptide)
NIP-cap (3-iodo-4-hydroxy-5-nitrophenyl-acetyl caproic acid)
Paratope of anti-(N-glycolylneuraminic acid (NeuGc, NGNA)-gangliosides GM3) Mus musculus IgM-kappa P3
PcrV (located at the tip of the syringe-like TTSS (Type Three Secretion System))
Phosphatidylserine
PLAP (placental alkaline phosphatase; EC 3.1.3.1)
PLAP-like testicular alkaline phosphatase
PSCA (prostate stem cell antigen)
Pseudomonas aeruginosa serotype IATS O11
PSMA (prostate specific membrane antigen)
Rabies virus glycoprotein
RSV (respiratory syncytial virus)
SELE (E-selectin; CD62E)
SELP (P-selectin; CD62P)
SLAM7 (SLAM family member 7; CD2 subset 1; CS1; CRACC, CD2-like receptor-activating cytotoxic cells; 19A24; CD319)
T cell transmembrane protein
TAG 72 (tumour associated glycoprotein 72)
TGF-1 (Transforming Growth Factor 1)
TGFB (Transforming Growth Factor Beta)
TGFB2 (transforming growth factor beta 2)
TNC (Tenascin C; HBX, hexabrachion)
TNF (tumor necrosis factor; TNFA, TNF-alpha; TNFSF2)
TNFRSF10B (tumor necrosis factor receptor superfamily member 10B; DR5, death receptor 5; TRAIL-R2, TNF-related apoptosis-inducing ligand receptor 2; TR-2; CD262)
TNFRSF13C (tumor necrosis factor receptor superfamily member 13C; BAFFR; BR3, B cell activating factor receptor; CD268)-IGHG1 Fc
TNFRSF8 (tumor necrosis factor receptor superfamily member 8; CD30)
TNFSF11 (tumor necrosis factor ligand superfamily member 11; RANKL, receptor activator for nuclear factor kappa B ligand; human osteoclast differentiation factor)
TNFSF13B (Tumor necrosis factor superfamily 13B; BAFF, B cell activating factor; BLyS, B lymphocyte activator; CD257; TNFS13, tumor necrosis factor superfamily 13; APRIL, a proliferation-including ligand; CD256)
TNFSF8 (tumor necrosis factor ligand superfamily member 8; CD30L, CD30 ligand)
Toxin
TPBG (trophoblast glycoprotein; 5T4)
TRAIL-R1 (Tumor necrosis apoprosis Inducing ligand Receptor 1)
TRαβ (T cell receptor alpha/beta)
Tumor associated antigen CA125
VEGF-A (Vascular Endothelial Growth Factor A)
VEGFA (Vascular Endothelial Growth Factor A)
Specificity origin
-
any
none
bacteria
Candida albicans
Clostridium perfringens
Homo sapiens (human)
Staphylococcus epidermidis
virus
Company
Development status
-
any
none
Phase I
Phase I/II
Phase Ib
Phase II
Phase II/III
Phase III
Phase IV (PA)
Phase M
Preclinical
Proof of concept
Withdrawn
Clinical indication
Regulatory agency
-
any
none
AMM
Discontinued
EC
EMEA
FDA
NCI
NDA
SBLA
Expression system
Year
-
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
Application
-
any
none
Diagnostic
Therapeutic
Clinical domain
-
any
none
Hematology
Hereditary inflammatory diseases
Immunology
Oncology
Ophthalmology
Pulmonary
Radioimmunoscintigraphy
Respiratory diseases
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IMGT/mAb-DB ID
INN
INN number
INN Prop. list
INN Rec. list
Common name
Proprietary name
IMGT/mAb-DB section
Radiolabelled/ Conjugated
IMGT/2Dstructure-DB
IMGT/3Dstructure-DB
Isotype and format
Fusion protein format
Origin clone species
Origin clone name
Specificity and origin
Company
Clinical indication
Development status
Regulatory agency status and year
Expression system
FDA number
EMEA number
ATC code
NCI number
Drug number
References
Application
Clinical domain