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Glycosylation

Glycosylation sites

N (Asn, asparagine) are potential N-glycosylation sites when they are part of the N-glycosylation motif NXS/T, where X is any amino acid except proline. Glycans are linked to the nitrogen atom N (N-linked glycosylation).

S (Ser, serine) and T (Thr, threonine) are potential glycosylation sites but the motifs are not very conserved. Glycans are linked to the oxygen atom O (O-linked glycosylation).

Antibody glycosylation

Glycosylation of IgG antibodies determines biologic functions mediated through cellular Fc receptors (FcγR), the C1q component of the classical pathway of complement, mannan binding ligand (MBL) and the mannose receptor (MR). FcγR and C1 binding are dependent on core oligosaccharide structure, MBL and MR by terminal sugar residues (glycoforms).