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QUESTION 2:
What is the organization of the human TRB locus?
ANSWER to question 2:
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The human TRB locus on chromosome 7 at 7q34 spans 620 kb. It consists of 82-85 genes: 64-67 TRBV, 2 TRBD, 14 TRBJ and 2 TRBC genes. Except for TRBV30, localized downstream of the TRBC2 gene, in inverted orientation of transcription, all the other TRBV genes are localized upstream of a duplicated D-J-C-cluster, which comprises, for the first part 1 TRBD, 6 TRBJ and the TRBC1 gene, and for the second part, 1 TRBD, 8 TRBJ and the TRBC2 gene. In contrast to the other TRBV genes, TRBV30 rearranges by an inversion mechanism. |
Created: 11/06/2001
Last updated: Friday, 29-Jul-2011 22:30:04 CEST
Author: Marie-Paule Lefranc
Editor: Elodie Foulquier
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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