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QUESTION 6:

Are all the human TRB genes known?
How to analyse the expressed variable TRB genes?

ANSWER to question 6:

All the human TRB genes are known and well characterized. The human TRB genes were approved by the HUGO Nomenclature committee in 1999 (http://www.hugo-international.org/) and entered in the Genome Database GDB, Canada (http://www.ncbi.nlm.nih.gov/sites/genome) and into Entrez Gene (http://www.ncbi.nlm.nih.gov/gene) at NCBI, USA.
A complete list is available in the IMGT Repertoire.
IMGT/GENE-DB an IMGT database for the human IG and TR genes
IMGT/V-QUEST, an IMGT tool for the analysis of the Variable genes, provides:
1) the identification of the TRBV, TRBD and TRBJ genes involved in the rearrangements,
2) the characterization of the V-D-J-JUNCTION,
3) the 2D representation or Collier de Perles.

Created: 11/06/2001
Last updated: Wednesday, 29-Jun-2011 17:01:45 CEST
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editor: Elodie Foulquier
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.

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