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QUESTION 2:
What is the organization of the human TRD locus?
ANSWER to question 2:
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The human TRD locus on chromosome 14 at 14q11.2 comprises a cluster of 10 genes: 1 TRDV, 3 TRDD and 4 TRDJ, the unique TRDC gene, and 3' of TRDC, 1 TRDV in inverted orientation. The cluster spans 60kb and is localized between the TRAV and TRAJ genes. 1 TRDV gene is localized at 360 kb of TRDC, among the TRAV genes. 5 genes described as TRAV/DV have been found rearranged to either TRDD or to TRAJ, and can therefore be used for the synthesis of delta and alpha chains. |
Created: 11/06/2001
Last updated: Friday, 29-Jul-2011 22:30:04 CEST
Editor: Elodie Foulquier
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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