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Nomenclature of the human LRC (Leucocyte Receptor Complex) genes: LILR/ILT and KIR (19q13.42)
There are two major cluster of genes for human NK receptors, the NKC (Natural Killer Complex) at 12p13.2 and the LRC (Leucocyte Receptor Complex) at 19q13.42. The LRC genes at 19q13.42 [1] comprises activating and inhibitory MHC receptors.
LRC genes are listed at 19q13.42 from the centromeric end of the LRC region (top of the table) to the telomeric end of the LRC region (bottom of the table). The number of KIR genes is different between haplotypes. None of the haplotypes described so far contained all the genes and some genes are only present in some haplotypes [2].
KIR haplotype A: 3DL3, 2DL3, 2DP1(Z), 2DL1, 3DP1(X), 2DL4, 3DL1, 2DS4, 3DL2
KIR haplotype B (AL133414): 3DL3, 2DL2, 3DP1(X), 2DL4, 3DS1, 2DL5, 2DS5, 2DS1, 2DS2, 3DL2
LILR/ILT are orthologous in humans and mice so primordial genes must have been present before speciation between man and rodents (about 80 million years ago), but KIR originally thought to be completely absent in rodents and only developed in primates [3], have now been detected in rodents [6].
| Cells | HUGO nomenclature | Aliases | CD designation [4] | Sequences | C (1) | Function Motif | Ligands | |
| Monocytes Macrophages Dentritic cells B lymphocytes |
LILRB3 | ILT5 | LIR3, HL9 | CD85a | U91928 | 4 | Inhibitory ITIM | ? |
| LILR? | ILT8 | - | CD85b | AF041262 | ||||
| LILRB5 | - | LIR8 | CD85c | AF025534 | 4 | Inhibitory ITIM | ||
| LILRB2 | ILT4 | LIR2, MIR10 | CD85d | AF000574 | 4 | Inhibitory ITIM | HLA-A, B, F and G | |
| LILRA3 | ILT6 | LIR4, HM31, HM43 | CD85e | U91926 | 4 | (2) | ? | |
| LILR? | ILT11 | - | CD85f | AF212842 | 2 | (3) | ||
| LILR? | ILT7 | - | CD85g | AF041261 | (3) | |||
| LILRA2 | ILT1 | LIR7 | CD85h | U82275 | 4 | (3) | ||
| LILRA1 | - | LIR6 | CD85i | AF025530 | 2 ou 3 | |||
| LILRB1 | ILT2 | LIR1, MIR7 | CD85j | AF009220 | 4 | Inhibitory ITIM | HLA-A, B, F and G | |
| LILRB4 | ILT3 | LIR5, HM18 | CD85k | U82979 | 2 | Inhibitory ITIM | ? | |
| LILR? | ILT9 | - | CD85l | AF072102 | ||||
| LILR? | ILT10 | - | CD85m | AF072100 | ||||
| NK cells T cell subsets |
KIR3DL3 | A, B | KIRC1, KIR44, KIR3DL7 | CD158z | AL133414 | 3 | Inhibitory ITIM | ? |
| KIR2DL3 | A* | p58.3 | CD158b2 | - | 2 | Inhibitory ITIM | HLA-C (S77-N80, -Cw1, -CW3, -Cw7, -Cw8) | |
| KIR2DL2 | B* | p58.2 | CD158b1 | AL133414 | ||||
| KIR2DP1 | A* | KIRZ (P) | - | AF204908 | - | - | - | |
| KIR2DL1 | A* | p58.1 | CD158a | - | 2 | Inhibitory ITIM | HLA-C (N77-K80, -Cw2, -Cw4, -Cw5, -Cw6) | |
| KIR3DP1 | A, B | KIR2DS6, KIRX (P) |
CD158c | AF133414 | - | - | ||
| KIR2DL4 | A, B | CD158d | AL133414 | 2 | Inhibitory ITIM | HLA-G | ||
| KIR3DL1 | A** | p70 | CD158e1 | - | 3 | Inhibitory ITIM | HLA-B (I80, Bw4) | |
| KIR3DS1 | B** | p70 | CD158e2 | AL133414 | Activator (4) | ? | ||
| KIR2DL5A (5) | B | CD158f | AL133414 | 2 | Inhibitory ITIM | ? | ||
| KIR2DL5B (5) | - | - | 2 | Inhibitory ITIM | ? | |||
| KIR2DS3 | - | - | - | 2 | Activator (4) | ? | ||
| KIR2DS1 | B | p50.1 | CD158h | AL133414 | 2 | Activator (4) | HLA-C (N77-K80, -Cw2, -Cw4, -Cw5, -Cw6) | |
| KIR2DS4 | A*** | p50.3 | CD158i | - | 2 | Activator (4) | ? | |
| KIR2DS5 | B*** | CD158g | AL133414 | 2 | Activator (4) | ? | ||
| KIR2DS2 | B | p50.2 | CD158j | AL133414 | 2 | Activator (4) | ? | |
| KIR3DL2 | A, B | p140 | CD158k | AL133414 | 3 | Inhibitory ITIM | HLA-A3, -A11? | |
HUGO nomenclature for LILR
HUGO nomenclature for KIR
Abbreviation:
IMGT notes:
| (1) | Number of C-LIKE -DOMAINs |
| (2) | No transmembrane region, probably soluble |
| (3) | Associated to FcRgamma (to be checked) |
| (4) | Associated to TYROBP/DAP12/Karap |
| (5) | Two related nonallelic KIR2DL5 genes were identified: KIR2DL5A and KIR2DL5B [5]. Haplotypes may comprise 0, 1 or 2 KIR2DL5 genes. |
References:
| [1] | Suto, Y. et al., Immunogenetics, 48, 235-241 (1998) |
| [2] | Trowsdale, J., Immunity, 15, 363-374 (2001) |
| [3] | Khakoo, S.I. et al., Immunity, 12, 687-698 (2000) |
| [4] | André, P. et al., Nature Immunology, 2, 661 (2001) |
| [5] | Gómez-Lozano, N. et al., Immunogenetics, 54, 314-319 (2002) |
| [6] | The KIR Gene Cluster, Mary Carrington and Paul
Norman, Bethesda (MD), National Library of Medicine (US), NCBI, 2003
 |
Created: 14/11/2001
Last updated: Wednesday, 29-Jun-2011 17:01:52 CEST
Author: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Editors: Elodie Foulquier, Chantal Ginestoux
Contact: Marie-Paule Lefranc
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