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DESCRIPTION

The 'DESCRIPTION' axiom is one of the seven axioms of the Formal IMGT-ONTOLOGY or IMGT-Kaleidoscope [1-3].

The 'DESCRIPTION' axiom postulates that molecules, cells, organs, organisms or populations and their processes and relations have to be described. In molecular immunogenetics, the 'DESCRIPTION' axiom postulates that IG, TR and MHC sequences have to be described and their specific and conserved motifs be characterized [1]. The 'DESCRIPTION' axiom has generated concepts of description, for example:

the 'Entity Prototype' concept
the 'Core' concept
the 'Cluster' concept
the 'Domain' concept

References:
[1]	Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999). PMID: 10745995, LIGM:221
[2]	Giudicelli, V. and Lefranc, M.-P. "Le paradigme IMGT-ONTOLOGY" In: Biologie Systémique Standards et modèles (Roux M. Ed.), Collection Ecrin, Omniscience, Presses Universitaires de France, Paris, 2007, Chapitre 6, pp143-164. ISBN: 978-2-916097-12-1
[3]	Duroux, P. et al., "IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm", Biochimie, 90, 570-583 (2008). Epub 2007 Sep11. PMID: 17949886

ImmunoGrid, The European Virtual Human Immune System Project (IST-2004-028069)
D1.2 Scientific chart rules and ontologies report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes the IMGT-ONTOLOGY concepts of identification, description and classification at the molecular level, generated from the IDENTIFICATION, DESCRIPTION and CLASSIFICATION axioms of the Formal IMGT-ONTOLOGY (IMGT-Kaleidoscope).
D1.3 IMGT unique numbering and controlled vocabularies report
Marie-Paule Lefranc, François Ehrenmann, Patrice Duroux and Véronique Giudicelli
Describes the IMGT-ONTOLOGY concepts of numerotation at the molecular level, generated from the NUMEROTATION axiom of the Formal IMGT-ONTOLOGY (IMGT-Kaleidoscope). Two major concepts of numerotation, IMGT unique numbering and IMGT Collier de Perles, are used to define the V, C and G type domains.
D1.4 New concepts of "INTERACTION" and "LOCALIZATION" and deduced IMGT Scientific chart rules report
Marie-Paule Lefranc, François Ehrenmann, Véronique Giudicelli and Patrice Duroux
Describes IMGT-ONTOLOGY concepts of interaction for the characterization of antigen/receptor and domain interactions. Two major concepts of interaction, pMHC contact site and IMGT Residue@Position, are used, respectively, to define peptide/MHC interactions, and more generally antigen/receptor and domain interactions.

See also:

Created: 22/05/2001
Last updated: Wednesday, 01-Apr-2009 18:09:02 CEST
Authors: Jean-Marc Vuillemin, Véronique Giudicelli and Marie-Paule Lefranc
Editors: Elodie Foulquier, Chantal Ginestoux
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

IMGT founder and director: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr
Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr
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