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Fusion proteins for immune applications (FPIA)

Fusion proteins for immune applications (FPIA) are genetically engineered proteins resulting from the fusion of high-affinity peptide, region and/or domain of protein(s), with at least one constant domain of IG or TR, for use in immune applications.

Examples of FPIA are the INN 'cept' proteins, or immunoadhesins in IMGT/mAb-DB, in which region and/or domain of protein(s) (soluble or cell surface receptor) are linked to the Fc of an immunoglobulin.

Note that fusion proteins with at least one IG variable domain are among the INN 'mab'. If the protein that is linked to the IG (or Fab, scFv...) is a toxin, the resulting antibody is also defined as an 'immunotoxin' in IMGT/mAb-DB.

See also:

• Immunoglobulins
• Major histocompatibility complex
• Receptor type
• RPI
• Superfamily
• T cell receptors

Created: 05/08/2009
Author: Marie-Paule Lefranc
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc

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For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

     

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