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About IMGT

Only major updates are reported here.
Other updates are reported in individual pages or chapters.

2010

29 June 2010 - UPDATE: Gene table: Human (Homo sapiens) IGHV orphons in IMGT Repertoire (IG and TR)

  1. Addition of a the new orphon gene IGHV/OR21, localized on chromosome 21 in the Gene table: Human (Homo sapiens) IGHV orphons.

28 May 2010 - UPDATE: Human (Homo sapiens) IGH orphon in IMGT/GENE-DB

  1. Addition of a new Chromosomal orphon set: IGHV/OR21, localized on chromosome 21 in IMGT/GENE-DB
  2. Addition of a new orphon gene: IGHV1/OR21-1 in IMGT/GENE-DB

7-11 May 2010 - CREATION: Alignments of alleles: Rabbit Oryctolagus cuniculus IGK in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Rabbit (Oryctolagus cuniculus) IGK V-REGION
  2. Creation of Alignments of alleles: Rabbit (Oryctolagus cuniculus) IGK J-REGION
  3. Creation of Alignments of alleles: Rabbit (Oryctolagus cuniculus) IGK C-REGION

22 April 2010 - CREATION: IMGT-ONTOLOGY at the NCBO BioPortal

  1. IMGT-ONTOLOGY formalized in OWL at NCBO BioPortal http://bioportal.bioontology.org/ (IDENTIFICATION axiom)

15 April 2010 - UPDATE: Rabbit (Oryctolagus cuniculus) IGKC1 in IMGT/GENE-DB

  1. Creation of a new allele : IGKC1*09 (K01359) in IMGT/GENE-DB
  2. UPDATE of functionality of IGKC1*05 (X03050): initially F, now is ORF in IMGT/GENE-DB

12 April 2010 - CREATION: Sequences from Kabat in IMGT/2Dstructure-DB

  1. Addition of 146 Human (Homo sapiens) sequences from Kabat in IMGT/2Dstructure-DB
  2. Addition of 184 Mouse (Mus musculus) sequences from Kabat in IMGT/2Dstructure-DB
  3. Addition of 15 Rabbit (Oryctolagus cuniculus) sequences from Kabat in IMGT/2Dstructure-DB

12 April 2010 - UPDATE: Gene table: Rabbit (Oryctolagus cuniculus) IGKC

  1. Addition of 1 new allele IGKC1*09 (K01359) in Gene table: Rabbit (Oryctolagus cuniculus) IGKC
  2. UPDATE of functionality of IGKC1*05 (X03050): initially F, now is ORF.

15 February 2010 - CREATION: Protein displays: Rabbit (Oryctolagus cuniculus) IGKJ and IGKC in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Rabbit (Oryctolagus cuniculus) IGK J-REGIONs in IMGT repertoire
  2. Creation of Protein display: Rabbit (Oryctolagus cuniculus) IGK C-REGIONs in IMGT repertoire

05 February 2010 - UPDATE: Protein display: Rabbit (Oryctolagus cuniculus) IGKV in IMGT Repertoire (IG and TR)

  1. Addition of the new Protein display rules in the Protein display: Rabbit (Oryctolagus cuniculus) IGK V-REGIONs

01 February 2010 - UPDATE: Gene Table: Rabbit (Oryctolagus cuniculus) IGKV in IMGT Repertoire (IG and TR)

  1. Addition of "Allele name", "Strain", "Clone names", "Position in the sequence" columns in Gene table: Rabbit (Oryctolagus cuniculus) IGKV in IMGT Repertoire

29 January 2010 - UPDATE: Rabbit (Oryctolagus cuniculus) IGKV in IMGT/GENE-DB

  1. Addition of 68 IGKV genes in IMGT/GENE-DB, corresponding to 70 allelic sequences

2009

23 December 2009 - CREATION: Alignments of alleles: Dog Canis lupus familiaris TRGC in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Dog Canis lupus familiaris TRG C-REGIONs

15 December 2009 - CREATION: Alignments of alleles: Dog Canis lupus familiaris TRGV in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Dog Canis lupus familiaris TRG V-REGIONs

11 December 2009 - CREATION: Alignments of alleles: Dog Canis lupus familiaris TRGJ in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Dog Canis lupus familiaris TRG J-REGIONs

04 December 2009 - IMGT/mAb-DB is on-line

  1. IMGT/mAb-DB Query page is on-line in IMGT monoclonal antibodies database
  2. IMGT/mAb-DB Documentation is on-line in IMGT monoclonal antibodies database

30 November 2009 - UPDATE: Protein display: Rat (Rattus norvegicus) IGHC in IMGT Repertoire (IG and TR)

  1. Addition of amino acids resulting from the splicing in the Protein display: Rat (Rattus norvegicus) IGH C-REGIONs in IMGT Repertoire

25 November 2009 - CREATION: Protein displays: Dog (Canis lupus familiaris) TRGJ and TRGC in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Dog (Canis lupus familiaris) TRG J-REGIONs in IMGT Repertoire
  2. Creation of Protein display: Dog (Canis lupus familiaris) TRG C-REGIONs in IMGT Repertoire

02 November 2009 - UPDATE of IMGT/3Dstructure-DB (Version 4.0.0) and Related other IMGT® resources

  1. Update of Web interfaces for IMGT/3Dstructure-DB database and IMGT/DomainDisplay, IMGT/DomainGapAlign, IMGT/Collier-de-Perles and IMGT/StructuralQuery tools.
    • Improvements of the web interfaces (5 types of search, linked lists, ...)
    • Improvement of Sequence in IMGT format in the IMGT/3Dstructure-DB card, 'Chain sequence' section:
      • Plain (FASTA format)
      • With regions and domains
      • With FR-IMGT and CDR-IMGT
      • With cysteins involved in disulfide bridges and with N-glycosylation sites (INN entries)
      • With N-glycosylation sites (PDB entries)
    • Update of the IMGT domain reference directory from the IMGT/GENE-DB database. Addition of 163 Rattus norvegicus IGKV genes and alleles (136 functional, 6 ORF and 21 pseudogenes).
    • Update of IMGT/DomainGapAlign tool:
      • Improvement of the Web interface and the display of results
      • Highlight of the amino acids changes between the closest germline V-REGION (for 'V') or C-DOMAIN (for 'C) and the sequences submitted by users
      • IMGT mutation and AA change description (see IMGT amino acid classes)
      • Results summary (corresponding to the closest genes and alleles) with: CDR-IMGT lengths, Number of different AA in CDR-IMGT (CDR3 not included), FR-IMGT lengths, Number of different AA in FR-IMGT, Number of AA class changes and List of AA class changes.
    • Update of 3D visualization with Jmol:
      • The whole chain sequences are displayed in a box, indicating th chain ID, the IMGT Receptor description and the lenght of the chain. Users just have to click on a residue in sequences to visualize it in the Jmol applet (wireframe by default)
      • The interface is now composed of 5 sub-menus: Selection, View, coloration, IMGT and Paratope/epitope
      • Go to 3D visualization with Jmol for more details.

20 November 2009 - CREATION: Gene tables: Dog (Canis lupus familiaris) TRGJ and TRGC in IMGT Repertoire (IG and TR)

  1. Creation of the Gene table: Dog (Canis lupus familiaris) TRGJ in IMGT Repertoire
  2. Creation of the Gene table: Dog (Canis lupus familiaris) TRGC in IMGT Repertoire

21 October 2009 - UPDATE: Rat (Rattus norvegicus) IGKV, J and C in IMGT/GENE-DB

  1. Addition of 163 IGKV gapped sequences IMGT/GENE-DB
  2. Addition of 7 IGKJ sequences IMGT/GENE-DB
  3. Addition of 2 IGKC gapped sequences IMGT/GENE-DB

17 July 2009 - UPDATE: Dog (Canis lupus familiaris) TRGC in IMGT/GENE-DB

  1. Addition of artificially spliced exon(s) for functional and ORF TRGC genes in IMGT/GENE-DB

02 June 2009 - UPDATE of IMGT/Education

  1. Creation new pages IMGT Education Tutorials MHC

13 May 2009 - UPDATE: Rat (Rattus norvegicus) IGHC in IMGT/GENE-DB

  1. Addition of artificially spliced exon(s) for functional and ORF IGHC genes in IMGT/GENE-DB

07 May 2009 - Update of IMGT Repertoire (MHC) and IMGT Repertoire (RPI)

  1. IMGT Repertoire MHC: addition of Oncorhynchus mykiss (rainbow trout) MHC-I and MHC-II genes.
  2. IMGT Repertoire RPI: update of MICA alleles, update of RPI entries.

29 April 2009 - CREATION: Protein display: Dog (Canis lupus familiaris) TRG V-REGIONs in IMGT Repertoire (IG and TR)

  1. Creation of the Protein display: Dog (Canis lupus familiaris) TRG V-REGIONs in IMGT Repertoire

27 April 2009 - UPDATE of IMGT/V-QUEST (Version 3.2.0)

  1. Addition of "Export in Excel file output : the "Detailed view" results are recorded in 11 sheets.
  2. Query Page : the option "2. Alignment for D-GENE" of "A. Detailed view" is no more selected by default.
  3. A. Detailed view results:
    • In "Result summary", D-GENE(s) and allele(s) are shown only if identified by IMGT/JunctionAnalysis"
    • In "4. Results of IMGT/JunctionAnalysis"
      • In case of unmutated IGK or IGL V-GENE (no mutations in FR1-IMGT, CDR1-IMGT, FR2-IMGT, CDR2-IMGT and FR3-IMGT), the number of allowed mutations in 3'V-REGION and 5'J-REGION has been set to 2.
      • The number of accepted D-GENE in the junction is indicated
    • In "10. V-REGION mutation statistics": update of the presentation of the amino acid table
    • In "11. V-REGION mutation hot spots": the tables are displayed as follow: (a/t)a, t(a/t), (a/g)g(c/t)(a/t), (a/t)(a/g)c(c/t)
    • In "13. Sequences of V-, V-J- or V-D-J- REGION ('nt' and 'AA') with gaps in FASTA": the V-J- or V-D-J- REGION amino acid sequences are shown in red for unproductive sequences with an out-of-frame junction.
  4. "Export in text" output : elimination of HTML tags (except for option "5. V-REGION protein display with colored AA according to the AA IMGT Classes" of Synthesis View).
  5. "B. Synthesis view results": in "7. V-REGION most frequently occurring AA per position and per FR-IMGT and CDR-IMGT", a message is added when, at a given position, 100% of the analyzed sequences have the same AA change.
  6. Update of IMGT gap positions in Homo sapiens IGHV3-72*02.

2008

5 December 2008 - UPDATE: IMGT/GENE-DB

  1. Sequences in FASTA format :update of the header: The FASTA header contains 15 fields separated by '|':
    • IMGT/LIGM-DB accession number(s)
    • gene and allele name
    • species
    • functionality
    • exon(s), region name(s), or extracted label(s)
    • start and end positions in the IMGT/LIGM-DB accession number(s)
    • number of nucleotides in the IMGT/LIGM-DB accession number(s)
    • codon start, or 'NR' (not relevant) for non coding labels
    • +n: number of nucleotides (nt) from an upstream donor exon, added in 5' of an exon, to obtain a complete first codon (for C-GENE exons if splicing frame 1 or 2)
    • -n: number of nucleotides (nt) deleted in 3' of an exon, to obtain a complete last codon (for C-GENE exons if splicing frame 1 or 2)
    • +n, -n, and/or nS: number of added, deleted, and/or substituted nucleotides to correct sequencing errors, or 'not corrected' if non corrected sequencing errors
    • number of amino acids (AA): this field indicates that the sequence is in amino acids
    • number of characters in the sequence: nt (or AA)+IMGT gaps=total
    • partial (if it is)
    • reverse complementary (if it is)
  2. Update of the IMGT/GENE-DB Direct links page.
  3. Update of the IMGT/GENE-DB entry.

3 to 5 December 2008 - CREATION: Gene tables: Rat (Rattus norvegicus) IGLV, IGLJ and IGLC in IMGT Repertoire (IG and TR)

  1. Creation of Gene table: Rat (Rattus norvegicus) IGLV in IMGT Repertoire
  2. Creation of Gene table: Rat (Rattus norvegicus) IGLC in IMGT Repertoire
  3. Creation of Gene table: Rat (Rattus norvegicus) IGLJ in IMGT Repertoire

28 November 2008 - UPDATE: Rat (Rattus norvegicus) IGLC in IMGT/GENE-DB

  1. Addition of IGLC4 gene sequence and update of IGLC reference sequences in IMGT/GENE-DB

24 November 2008 - UPDATE: Rat (Rattus norvegicus) IGLJ in IMGT/GENE-DB

  1. Addition of IGLJ4 gene sequence and update of IGLJ reference sequences in IMGT/GENE-DB

18 November 2008 - CREATION: IMGT/2Dstructure-DB

IMGT/2Dstructure-DB, a database of monoclonal antibodies and -cept. The data source is the International Nonproprietary Names (INN) programme of the World Health Organization (WHO).

  1. Integration of 39 INN entries ( 34 monoclonal antibodies and 5 -cept) in IMGT/2Dstructure-DB.
  2. The IMGT/2Dstructure-DB INN card can be obtained searching by INN number and contains IMGT chain and domain details, renumbered IMGT file and INN definitions and properties.

1 October 2008 - UPDATE: Gene table: Rabbit (Oryctolagus cuniculus) IGKC in IMGT Repertoire (IG and TR)

  1. Addition of "Allele name", "Strain", "Clone names", "Position in the sequence" columns in Gene table: Rabbit (Oryctolagus cuniculus) IGKC in IMGT Repertoire

1 October 2008 - UPDATE: Rabbit (Oryctolagus cuniculus) IGKJ and IGKC genes in IMGT/GENE-DB

  1. Addition of 2 Rabbit (Oryctolagus cuniculus) IGKC genes in IMGT/GENE-DB, corresponding to 12 allelic sequences
  2. Addition of 8 Rabbit (Oryctolagus cuniculus) IGKJ genes in IMGT/GENE-DB, corresponding to 19 allelic sequences

30 September 2008 - UPDATE: Gene table: Rabbit (Oryctolagus cuniculus) IGKJ in IMGT Repertoire (IG and TR)

  1. Addition of "Allele name", "Strain", "Clone names", "Position in the sequence" columns in Gene table: Rabbit (Oryctolagus cuniculus) IGKJ in IMGT Repertoire

16 September 2008 - UPDATE: IMGT Aide-Memoire of Splicing sites in IMGT Web resources

  1. Update the Splicing sites table in IMGT Aide-mémoire
  2. Modification of the "Splicing frame" and "IMGT notes" paragraphes in IMGT Aide-mémoire

5 September 2008 - CREATION: FR-IMGT lengths for comparison of humanized antibodies in IMGT Repertoire (IG and TR)

  1. Creation of FR-IMGT lengths for comparison of humanized antibodies in IMGT Repertoire

22 August 2008 - CREATION: Protein displays: Rabbit (Oryctolagus cuniculus) IGLJ and IGLC in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Rabbit (Oryctolagus cuniculus) IGL J-REGIONs in IMGT Repertoire
  2. Creation of Protein display: Rabbit (Oryctolagus cuniculus) IGL C-REGIONs in IMGT Repertoire

21 August 2008 - CREATION: Protein displays: Rat (Rattus norvegicus) IGHC in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Rat (Rattus norvegicus) IGH C-REGIONs in IMGT Repertoire

12 August 2008 - UPDATE: Rat (Rattus norvegicus) IGHC in IMGT/GENE-DB

  1. Addition of IGHC gapped sequences in IMGT/GENE-DB

12 August 2008 - CREATION: Gene tables: Rabbit (Oryctolagus cuniculus) IGLJ and IGLC in IMGT Repertoire (IG and TR)

  1. Creation of Gene table: Rabbit (Oryctolagus cuniculus) IGLJ in IMGT Repertoire
  2. Creation of Gene table: Rabbit (Oryctolagus cuniculus) IGLC in IMGT Repertoire

12 August 2008 - UPDATE: Rabbit (Oryctolagus cuniculus) IGLJ and IGLC in IMGT/GENE-DB

  1. Addition of 2 IGLJ sequences in IMGT/GENE-DB
  2. Addition of 6 IGLC gapped sequences in IMGT/GENE-DB

8 August 2008 - CREATION: Correspondence between numberings for CDR of different lengths (horizontal display per locus) in IMGT Scientific chart

  1. Creation of Correspondence between numberings for CDR of different lengths (horizontal display per locus)

30 July 2008 - CREATION: Gene table: Black Rat (Rattus rattus) IGHC in IMGT Repertoire (IG and TR)

  1. Creation of Germline gene table: Black Rat (Rattus norvegicus) IGHC in IMGT Repertoire

28 July 2008 - CREATION: Gene table: Norway Rat (Rattus norvegicus) IGHC in IMGT Repertoire (IG and TR)

  1. Creation of Germline gene table: Norway Rat (Rattus norvegicus) IGHC in IMGT Repertoire

24 July 2008 - UPDATE: Gene table: Rat (Rattus norvegicus) IGHV in IMGT Repertoire (IG and TR)

  1. Update of IMGT notes of the Germline gene table: Rat (Rattus norvegicus) IGHV in IMGT Repertoire

18 June 2008 - CREATION: Alignments of alleles: Rat (Rattus norvegicus) IGHV in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Rat (Rattus norvegicus) IGHV in IMGT Repertoire

4 June 2008 - CREATION: Alignments of alleles: Rat (Rattus norvegicus) IGHJ in IMGT Repertoire (IG and TR)

  1. Creation of Alignments of alleles: Rat (Rattus norvegicus) IGHJ in IMGT Repertoire

3 June 2008 - CREATION: Germline gene table: Rat (Rattus norvegicus) IGHJ in IMGT Repertoire (IG and TR)

  1. Creation of Germline gene table: Rat (Rattus norvegicus) IGHJ in IMGT Repertoire

3 June 2008 - CREATION: Protein displays: Rat (Rattus norvegicus) IGHJ in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Rat (Rattus norvegicus) IGH J-REGIONs in IMGT Repertoire

31 March 2008 - UPDATE: Rat (Rattus norvegicus) IGL locus in IMGT/GENE-DB

  1. Addition of 3 IGLJ sequences IMGT/GENE-DB
  2. Addition of 3 IGLC sequences IMGT/GENE-DB

6 March 2008 - CREATION: Protein displays: Rat (Rattus norvegicus) IGHV in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Rat (Rattus norvegicus) IGH V-REGIONs in IMGT Repertoire

6 March 2008 - ENHANCEMENT of IMGT/GENE-DB

  1. Addition of table of annotated IMGT/3Dstructure-DB structures for each IMGT/GENE-DB gene

27 February 2008 - CREATION: Protein displays and Alignment of alleles: Rat (Rattus norvegicus) IGHD in IMGT Repertoire (IG and TR)

  1. Creation of Alignment of alleles: Rat (Rattus norvegicus) IGHD (overview) in IMGT Repertoire

26 February 2008 - CREATION: Protein displays: Rat (Rattus norvegicus) IGLV in IMGT Repertoire (IG and TR)

  1. Creation of Protein display: Norway Rat (Rattus norvegicus) IGL V-REGIONs in IMGT Repertoire

25 February 2008 - UPDATE: Rat (Rattus norvegicus) IGLV in IMGT/GENE-DB

  1. Addition of 7 IGLV gapped sequences IMGT/GENE-DB

19 February 2008 - ENHANCEMENT of IMGT/V-QUEST (Version 3.0.0)

  1. From this release, gaps in CDR1-IMGT and CDR2-IMGT are placed at the top of the loops

19 February 2008 - CREATION: Germline gene table: Rat (Rattus norvegicus) IGHD in IMGT Repertoire (IG and TR)

  1. Creation of Germline gene table: Rat (Rattus norvegicus) IGHD in IMGT Repertoire

8 February 2008 - UPDATE of IMGT/V-QUEST (Version 2.5.1)

  1. Addition of Human (Homo sapiens) IGHV3-49*04 IGHV3-49*05 IGHV4-39*07 alleles

29 January 2008 - ENHANCEMENT of IMGT/V-QUEST (Version 2.5.0)

  1. Addition of an option in Advanced parameters: "Search for insertions and deletions"
  2. Update of Rat (Rattus norvegicus) IGHV reference directory
  3. Update of Mouse (Mus musculus) IGHV reference directory

25 January 2008 - CREATION: Germline gene table: Rat (Rattus norvegicus) IGHV in IMGT Repertoire (IG and TR)

  1. Creation of Germline gene table: Rat (Rattus norvegicus) IGHV in IMGT Repertoire

10 January 2008 - ENHANCEMENT of IMGT/GENE-DB

  1. Addition of table of annotated IMGT/LIGM-DB rearranged genomic DNA sequences for each IMGT/GENE-DB gene

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2007

15 November 2007 - UPDATE: Rat (Rattus norvegicus) IGHV in IMGT/GENE-DB

  1. Addition of 161 Rat (Rattus norvegicus) IGHV genes in IMGT/GENE-DB

3 October 2007 - UPDATE: Rat (Rattus norvegicus) IGHV and IGHC in IMGT/GENE-DB

  1. Addition of 94 Rat (Rattus norvegicus) IGHV genes in IMGT/GENE-DB
  2. Addition of 8 Rat (Rattus norvegicus) IGHC genes in IMGT/GENE-DB

31 July 2007 - UPDATE: Mouse (Mus musculus) IGHV in IMGT Repertoire (IG and TR)

  1. Addition of genes: IGHV1-70 to IGHV1-86, IGHV8-15 and IGHV8-16 in Gene table: Mouse (Mus musculus) IGHV
  2. Addition of genes: IGHV1-70 to IGHV1-86, IGHV8-15 and IGHV8-16 in Locus representation: Mouse (Mus musculus) IGH

26 July 2007 - UPDATE: a new species Rat (Rattus norvegicus) in IMGT/V-QUEST

  1. Addition of a new species: Rat (Rattus norvegicus) IGH in IMGT/V-QUEST
    • 83 IGHV (belonging to IGHV2 and IGHV5 subgroups)
    • 19 IGHD
    • 4 IGHJ

20 July 2007 - ENHANCEMENT of IMGT/V-QUEST (Version 2.4.0)

  1. Addition of a new species: Rat (Rattus norvegicus) IGH in IMGT/V-QUEST
    • 83 IGHV (test for IGHV2 and IGHV5 subgroups)
    • 19 IGHD
    • 4 IGHJ
  2. Addition of 17 Mouse (Mus musculus) IGHV genes
    • IGHV1-70*01, IGHV1-71*01, IGHV1-72*01, IGHV8-13*01, IGHV1-74*01, IGHV8-14*01, IGHV1-75*01, IGHV1-76*01, IGHV1-77*01, IGHV1-78*01, IGHV1-79*01, IGHV1-80*01, IGHV1-81*01, IGHV1-82*01, IGHV1-83*01, IGHV1-84*01, IGHV1-85*01

16 July 2007 - CREATION: RPI entries from gene to protein in IMGT Repertoire (RPI)

  1. Creation of IgSF other than IG or TR entries for Human B7, CD2, CD3, CD79, CEACAM1, DSCAM, KIR2DL2, MOG, VPREB, VSIG4
  2. Creation of IgSF other than IG or TR entries for Mouse B7, CD2, CD3, CD4, CD8, CD79, VSIG4
  3. Creation of IgSF other than IG or TR entries for Drosophila melanogaster DSCAM

6 July 2007 - ENHANCEMENT of IMGT/V-QUEST (Version 2.3.0)

  1. IMGT/V-QUEST has been upgraded with a summary of the IMGT/V-QUEST results, provided in both "Detailed view" and "Synthesis view", at the top of the results.
  2. The "Advanced parameters" section has been added in the query page.
  3. In frame pseudogenes have been added in the IMGT/V-QUEST reference directory sets.

For more information on the IMGT/V-QUEST Version 2.3.0 improvements, see IMGT/V-QUEST Documentation.

18 June 2007 - CREATION: Germline gene table: Axolotl (Ambystoma mexicanum) TRAV in IMGT Repertoire (IG and TR)

  1. Creation of Germline gene table: Axolotl (Ambystoma mexicanum) TRAV in IMGT Repertoire

18 June 2007 - CREATION: Gene Positions

  1. Creation of Gene Positions in IMGT Repertoire

19 April 2007 - CREATION: Leader sequence logos of the mouse IG and TR V genes

  1. Creation of V-REGION sequence logos of the mouse IG and TR in IMGT Repertoire

18 April 2007 - CREATION: V-REGION sequence logos of the mouse IG and TR

Creation of V-REGION sequence logos of the mouse IG and TR in IMGT Repertoire

  1. V-REGION sequence logos
  2. V-REGION sequence logos for the seven loci
  3. Number of sequences for generating the V-REGION sequence logos for the seven loci

10 April 2007 - ENHANCEMENT of IMGT/V-QUEST (Version 2.2.0)

  1. IMGT/V-QUEST has been upgraded for the Results of IMGT/JunctionAnalysis.
  2. The IMGT/V-QUEST reference directory has been updated.

For more information on the IMGT/V-QUEST Version 2.2.0 improvements, see IMGT/V-QUEST Documentation.

25 March 2007 - UPDATE: IMGT/PRIMER-DB with new functionality : Comparison sequence

IMGT/PRIMER-DB allows to compare sequences against the IMGT/PRIMER-DB Database. For more information, see IMGT/PRIMER-DB Primer Sequence Comparison in IMGT/PRIMER-DB Documentation.

15 February 2007 - UPDATE: IMGT/DomainSuperimpose

  1. Possibility of choosing a coordinate file ID in a list

19 January 2007 - CREATION: V-REGION sequence logos of the human IG and TR

Creation of V-REGION sequence logos of the human IG and TR in IMGT Repertoire

  1. V-REGION sequence logos
  2. V-REGION sequence logos for the seven loci
  3. Number of sequences for generating the V-REGION sequence logos for the seven loci

16 January 2007 - CREATION: Recombination signal sequences and logos of the Mouse (Mus musculus) IG and TR V, D and J genes

Creation of Recombination signals of the Mouse (Mus musculus) IG and TR V, D and J genes in IMGT Repertoire

  1. Recombination signal sequences
  2. Recombination signal sequence logos
  3. Recombination signal sequence logo for the seven loci
  4. Number of sequences for generating the recombination signal sequence logo for the seven loci

11 January 2007 - UPDATE: Additional levels of classification in OC (Organism Classification) lines of IMGT/LIGM-DB

  1. Additional levels of classification have been added in the OC (Organism Classification) lines of IMGT/LIGM-DB, to follow closely all the levels of the NCBI (National Center for Biotechnology Information) Taxonomy.

9 January 2007 - CREATION: RFLP alleles and frequencies: Human IGHV

  1. Creation of RFLP alleles and frequencies for Human IGHV1-69 gene in IMGT Repertoire (IG and TR)

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2006

8 December 2006 - CREATION: Correspondence between the different Mouse (Mus musculus) TRAV subgroup nomenclatures in Correspondence between nomenclatures: Mouse (Mus musculus) TRAV

  1. Creation of Correspondence between the different subgroup nomenclatures, in Correspondence between nomenclatures: Mouse (Mus musculus) TRAV in IMGT Repertoire (IG and TR)

17 November 2006 - CREATION: Assignment of rearranged cDNAs and gDNAs to germline Mouse (Mus musculus) TRAJ genes

  1. Creation of Assignment of rearranged cDNAs and gDNAs to germline genes: Mouse (Mus musculus) TRAJ in IMGT Repertoire (IG and TR)

15 November 2006 - ENHANCEMENTof IMGT/V-QUEST (Version 2.1.0)

IMGT/V-QUEST has been upgraded to provide a Synthesis view of results. For more information on the IMGT/V-QUEST Version 2.1.0 improvements, see IMGT/V-QUEST Documentation.

07 November 2006 - CREATION: IMGT/DomainGapAlign Documentation

  1. Creation of IMGT/DomainGapAlign Documentation in IMGT structure tools

31 October 2006 - UPDATE: New IMGT/Phylogene upgraded for multiple sequences and with modified interface

  1. For more information, see improvements in IMGT/Phylogene documentation
  2. Update of the interface
  3. Update of the IG and TR sequences to analyse
  4. Use of PHYLIP 3.66 package

19 October 2006 - CREATION: Sheep (Ovis aries) TRG

  1. Creation of Chromosomal localization: Sheep (Ovis aries) TRG in IMGT Repertoire (IG and TR)
  2. Creation of Locus representation: Sheep (Ovis aries) TRG in IMGT Repertoire (IG and TR)
  3. Creation of Gene table: Sheep (Ovis aries) TRGJ in IMGT Repertoire (IG and TR)

28 September 2006 - CREATION: IMGT/DomainSuperimpose

  1. Creation of IMGT/DomainSuperimpose in IMGT structure tools

28 September 2006 - CREATION: IMGT/Collier-de-Perles

  1. Creation of IMGT/Collier-de-Perles in IMGT structure tools

28 September 2006 - CREATION: IMGT/DomainGapAlign

  1. Creation of IMGT/DomainGapAlign in IMGT structure tools

28 September 2006 - CREATION: IMGT/DomainDisplay

  1. Creation of IMGT/DomainDisplay in IMGT sequence tools

27 September 2006 - CREATION: Leader sequence logos of the human IG and TR V genes

  1. Creation of V-REGION sequence logos of the human IG and TR in IMGT Repertoire

19 September 2006 - CREATION: IMGT/GeneFrequency

  1. Creation of IMGT/GeneFrequency in IMGT genome tools

28 July 2006 - UPDATE: Monoclonal antibodies with clinical indications

Monoclonal antibodies with clinical indications

  1. Murine monoclonal antibodies
  2. Chimeric monoclonal antibodies
  3. Humanized monoclonal antibodies
  4. Human monoclonal antibodies
  5. Immunotoxins
  6. Other monoclonal antibodies

15 June 2006 - CREATION: Recombination signal sequences and logos (Homo sapiens) IG and TR V, D and J genes

Creation of Recombination signals of the human (Homo sapiens) IG and TR V, D and J genes in IMGT Repertoire

  1. Recombination signal sequences
  2. Recombination signal sequence logos
  3. Recombination signal sequence logo for the seven loci
  4. Number of sequences for generating the recombination signal sequence logo for the seven loci

11 May 2006 - ENHANCEMENT: New IMGT/V-QUEST upgraded for multiple sequences and with new functionalities (v2.0.0)

IMGT/V-QUEST has been upgraded for multiple sequences and with new functionalities. For more information on the IMGT/V-QUEST Version 2.0.0 improvements, see IMGT/V-QUEST Documentation.

2 March 2006 - UPDATE: Definitive nomenclature for the mouse (Mus musculus) IGHV genes

Definitive nomenclature. Update of Gene table: Mouse (Mus musculus) IGHV, with data for strains other than C57BL6/J.

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2005

5 November 2005 - CREATION: Definitive gene name nomenclature for mouse (Mus musculus)

Gene table: Mouse (Mus musculus) IGHV. This new gene table provides the definitive nomenclature for the mouse (Mus musculus) IGHV genes and thus completes the nomenclature for the seven mouse IG and TR loci. The temporary nomenclature table remains available as an archive.

  1. Creation of Locus representation with the definitive IGHV nomenclature
  2. Creation of Gene table: Mouse (Mus musculus) IGHV, with data for the C57BL6/J strain.

28 October 2005 - CREATION: IMGT Genes (DAS server) on the Ensembl Genome Browser

The links below give access to the human IG and TR loci in Ensembl
To see "IMGT Genes", go to the "Detailed View" section, click on the rolling menu "DAS Sources" and select "IMGT Genes".

Once "IMGT Genes" are displayed, clicking on an individual IMGT Gene opens a small window with a direct link to IMGT/GENE-DB.

  1. Homo sapiens IGH locus at 14q32.33:
  2. Homo sapiens IGK locus at 2p11.2:
  3. Homo sapiens IGL locus at 22q11.2:
  4. Homo sapiens TRA/TRD locus at 14q11.2:
  5. Homo sapiens TRB locus at 7q34:
  6. Homo sapiens TRG locus at 7p14:

01 August 2005 - CREATION: Primer Localization in IMGT/PRIMER-DB

  1. Creation of IMGT/PRIMER-DB Primer Localization in IMGT/PRIMER-DB
  2. Creation of IMGT/PRIMER-DB Primer Localization with graphical prototype gene representation (for V, D and J genes) in

Click on the button "Primer Localization", at the bottom of the IMGT/PRIMER-DB Primer cards.

20 July 2005 - CREATION: BLAST on IMGT/GENE-DB reference sequences

  1. Creation of BLAST at CINES on IMGT/LIGM-DB and on IMGT/GENE-DB reference sequences

12 May 2005 - CREATION: IMGT domain directory

  1. Creation of IMGT domain directory

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2004

4 November 2004 - ENHANCEMENT: IMGT/JunctionAnalysis

  1. Enhancement of the IMGT/JunctionAnalysis: Possibility to select up to 7 mutations in the 3'V-REGION and 5'J-REGION. This option is useful for the analysis of highly mutated IGK and IGL 3'V-REGIONs.

13 September 2004 - CREATION: IMGT pMHC contact sites in IMGT/3Dstructure-DB

  1. Definition and characterization of eleven standardized IMGT pMHC contact sites in IMGT/3Dstructure-DB

13 September 2004 - CREATION: IMGT Colliers de Perles for G-DOMAIN in IMGT/3Dstructure-DB

  1. Creation of IMGT Colliers de Perles for G-DOMAINs in IMGT/3Dstructure-DB. The IMGT Colliers de Perles for G-DOMAIN are based on the IMGT unique numbering for G-DOMAIN and G-LIKE-DOMAIN

05 July 2004 - CREATION: IMGT/GENE-DB Statistics

  1. Creation of IMGT/GENE-DB Statistics in IMGT/GENE-DE Query page

28 June 2004 - CREATION: IMGT/GENE-DB Direct links

  1. Creation of IMGT/GENE-DB Direct links in IMGT/GENE-DE Query page

28 June 2004 - ENHANCEMENT: IMGT/3Dstructure-DB

  1. Enhancement of the IMGT/3Dstructure-DB Colliers de Perles in the IMGT/3Dstructure-DB results: The "IMGT/3Dstructure-DB residue information" card of each residue of the IMGT Colliers de Perles on one layer or two layers can directly be obtained by clicking on the residue in the IMGT Colliers de Perles.

23 June 2004 - ENHANCEMENT: IMGT/V-QUEST enhancement with the integration of IMGT/JunctionAnalysis

  1. Enhancement of IMGT/V-QUEST with the integration of IMGT/JunctionAnalysis, in IMGT tools.

22 June 2004 - CREATION: IMGT Medical page

  1. Creation of IMGT Medical page.

22 June 2004 - CREATION: IMGT Veterinary page

  1. Creation of IMGT Veterinary page.

22 June 2004 - CREATION: IMGT Biotechnology page

  1. Creation of IMGT Biotechnology page.

25 May 2004 - CREATION: IMGT Lexique

  1. Creation of IMGT Lexique in IMGT Education.

10 May 2004 - ENHANCEMENT: IMGT/V-QUEST

  1. Enhancement of IMGT/V-QUEST in IMGT tools: IMGT/V-QUEST output enhancement with the addition of the nucleotide sequence and deduced amino translation of the closest germline V gene in the 'Translation of the input sequence' section of IMGT/V-QUEST results.

5 March 2004 - CREATION: IMGT/PRIMER-DB select bibliographic references

  1. Creation of IMGT/PRIMER-DB select bibliographic references in IMGT/PRIMER-DB Query page

15 January 2004 - CREATION: IMGT/GeneInfo

  1. Creation of IMGT/GeneInfo in IMGT Tools