In blue, the 41 positions at which more than 50 % of analysed IG and TR sequences show hydrophobic amino acids (hydropathy index with positive value: I, V, L, F, C, M, A) or Tryptophan (W) (M.-P. Lefranc, IMGT http://www.imgt.org 19/01/1999). These positions correspond to the Hydrophobic pattern for IG and TR V-REGION

Germline V-GENEs

The CDR3-IMGT region of germline IG and TR V-GENEs comprises position 105 to 115 (2-11 amino acids, depending on the V-GENE group or subgroup). The 3' end of germline CDR3-IMGT is limited by the V-HEPTAMER.

Rearranged V-J-GENEs or V-D-J-GENEs

The CDR3-IMGT region of rearranged IG and TR V-GENEs and V-D-J-GENEs (and that of corresponding cDNAs and proteins) comprises position 105 to 117 (position preceding J-PHE or J-TRP 118) (Colliers de perles in IMGT/3Dstructure-DB).

Created: 19/01/1999
Last updated: Tuesday, 13-Sep-2005 16:26:31 CEST
Contact: Marie-Paule Lefranc
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.

For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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