Click here to see Part 2 - Inversions involving the human IGH locus
| Locus | Chromosomal localization | Translocation | Other involved genes (1) | Clinical entities (2) |
IGH |
14q32.33 |
t(1;14)(p22;q32) | BCL10 | B cell lymphoma [Mucosa-Associated Lymphoid Tissue (MALT)] B cell lymphoma marginal zone |
| t(1;14)(q21;q32) | MUC1 | B cell peripheral neoplasm, NOS | ||
| t(2;14)(p13;q32) | BCL11A | B cell chronic lymphocytic leukemia (B-CLL) | ||
| t(3;14)(q27;q32) | BCL6 | non-Hodgkin lymphoma (NHL) diffuse large cell lymphoma (DLCL) (mainly) agressive lymphoma |
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| t(4;14)(p16;q32) | FGFR3 | plasma cell leukemia (PCL) multiple myeloma (MM) |
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| t(5;14)(q31;q32) | IL3 | B cell acute lymphoblastic leukemia (B-ALL) with hypereosinophilia | ||
| t(6;14)(p21;q32) | CCND3 | B-cell lymphoma splenic marginal zone | ||
| t(8;14)(q11;q32) | unknown (8q11) | B cell acute lymphoblastic leukemia (B-ALL) (mainly) chronic myelogenous leukemia (CML) B cell lymphoma (histiocyte-rich) |
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| t(8;14)(q24;q32) | MYC | B cell acute lymphoblastic leukemia (B-ALL) non-Hodgkin lymphomas (NHL), especially in Burkitt lymphoma |
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| t(9;14)(p13;q32) | PAX5 | lymphoplasmatic lymphoma |
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| t(10;14)(q24;q32) | NFKB2 | B cell lymphoma B cell acute lymphoblastic leukemia (B-ALL) non-Hodgkin lymphoma (NHL) |
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| t(11;14)(q13;q32) | CCND1 | mantle cell lymphoma B cell prolymphocytic leukemia (B-PLL) plasma cell leukemia (PCL) splenic lymphoma with villous lymphocytes B cell chronic lymphocytic leukemia (B-CLL) multiple myeloma (MM) other B cell lymphoproliferations |
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| t(14;18)(q32;q21) | BCL2 | follicular lymphoma (mainly) diffuse large cell lymphoma (DLCL) chronic lymphoproliferative disease (rarely) (CLD) |
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| t(14;19)(q32;q13.1) | BCL3 | B cell chronic lymphocytic leukemia (B-CLL) non-Hodgkin lymphoma (NHL), especially in Burkitt lymphoma |
IMGT notes:
| (1) | For the list of genes (other than IG or TR) involved in the translocations, click here. |
| (2) | Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here. |
| Locus | Chromosomal localization | Inversion | Other involved genes | Clinical entities |
| IGH | 14q32.33 | inv(14)(q11;q32) | TRA | T cell lymphoma |
Created: 29/03/2001
Last updated: Wednesday, 29-Jun-2011 17:06:03 CEST
Author: Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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