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Translocations and inversions: Human IGK

Translocations involving the IGK locus

Locus Chromosomal localization Translocation Other involved genes (1) Clinical entities (2)

IGK 2p11.2 t(2;3)(p11;q27) BCL6 non-Hodgkin lymphomas (NHL)
diffuse large cell lymphoma (DLCL) (mainly)

t(2;8)(p11;q24) MYC B cell acute lymphoblastic leukemia (B-ALL)
non-Hodgkin lymphomas (NHL), especially in the Burkitt lymphoma

t(2;18)(p12;q21) BCL2 B cell chronic lymphocytic leukemia (B-CLL)

IMGT notes:

(1) For the list of genes (other than IG or TR) involved in the translocations, click here.

(2) Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here.

Created: 23/11/2000
Last updated: Wednesday, 29-Jun-2011 17:06:10 CEST
Author:Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.

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Locus	Chromosomal localization	Translocation	Other involved genes (1)	Clinical entities (2)
IGK	2p11.2	t(2;3)(p11;q27)	BCL6	non-Hodgkin lymphomas (NHL) diffuse large cell lymphoma (DLCL) (mainly)
		t(2;8)(p11;q24)	MYC	B cell acute lymphoblastic leukemia (B-ALL) non-Hodgkin lymphomas (NHL), especially in the Burkitt lymphoma
		t(2;18)(p12;q21)	BCL2	B cell chronic lymphocytic leukemia (B-CLL)

(1)	For the list of genes (other than IG or TR) involved in the translocations, click here.
(2)	Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here.